Zobrazeno 1 - 10
of 1 814
pro vyhledávání: '"Healthspan"'
Autor:
Wenfeng Li, Shuming Chen, Jing Lang, Jing Luo, Jiahui Chen, Liping Zhang, Zhijie Sun, Deli Dong
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 3266-3280 (2024)
The drugs extending healthspan in clinic have always been searched. Nitazoxanide is an FDA-approved clinical antiprotozoal drug. Nitazoxanide is rapidly metabolized to tizoxanide after absorption in vivo. Our previous studies find that nitazoxanide a
Externí odkaz:
https://doaj.org/article/a97e426a84d445f1b4e36333464de582
Autor:
Lorcan S. Daly
Publikováno v:
Physiological Reports, Vol 12, Iss 21, Pp n/a-n/a (2024)
Abstract High caliber master athletes provide a valuable model for studying inherent physiological aging and performance capacity, without the confounding factor of physical inactivity. Despite the remarkable achievements of female master athletes, t
Externí odkaz:
https://doaj.org/article/53301d21e20f4a4f9031353150bbb545
Autor:
Wenmiao He, Zhiwei Liu, Hongchao Zhang, Qian Liu, Zhenkun Weng, Dongmei Wang, Wenhui Guo, Jin Xu, Dayong Wang, Zhaoyan Jiang, Aihua Gu
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 285, Iss , Pp 117136- (2024)
Bisphenol S (BPS) is widely presented and affects aging with unclear mechanisms. Here, we applied C. elegans to evaluate the effects of BPS on lifespan and healthspan and to investigate the underlying mechanisms. Both early-life and whole-life exposu
Externí odkaz:
https://doaj.org/article/b1653cb6c2474b3d908217e88cbffb8f
Publikováno v:
Food Frontiers, Vol 5, Iss 2, Pp 267-310 (2024)
Abstract The revolution in aging research through the past decade has driven the progress in interventions that promote longevity. Dissection of the “old” hallmarks of aging has provided solid data for the definition of at least three “new” o
Externí odkaz:
https://doaj.org/article/6c7100c28c064c3ead113d9ed49ff369
Autor:
Andrew MN Walker, Nicole T. Watt, Nadira Y. Yuldasheva, Sanjush Dalmia, Marcella Conning-Rowland, Chew W. Cheng, Nele Warmke, Katherine Bridge, Oliver I. Brown, Cheukyau Luk, Michael Drozd, Natalie J. Haywood, Anna Skromna, Natasha Makava, Stephen B. Wheatcroft, Mark T. Kearney, Richard M. Cubbon
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e36457- (2024)
Objective: Reduced IGF-1 signalling is an evolutionarily conserved mediator of longevity, yet the magnitude of this effect is substantially larger in organisms retaining a common insulin and IGF-1 receptor. Whether this reflects the failure to simult
Externí odkaz:
https://doaj.org/article/8e31cd24581c4d399766217804bdc0d5
Publikováno v:
Frontiers in Aging, Vol 5 (2024)
Externí odkaz:
https://doaj.org/article/ad861f47064f48d7b5dda565570393a5
Publikováno v:
Frontiers in Aging, Vol 5 (2024)
In recent years, there has been a paradigm shift with regards to ageing, challenging its traditional perception as an inevitable and natural process. Researchers have collectively identified hallmarks of ageing, nine of which were initially proposed
Externí odkaz:
https://doaj.org/article/63f3b0b5ee064d9d89191e044edaff3f
Autor:
Emma F. Jacquier, Amira Kassis, Diana Marcu, Nikhat Contractor, Jina Hong, Chun Hu, Marissa Kuehn, Christopher Lenderink, Arun Rajgopal
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
Considering a growing, aging population, the need for interventions to improve the healthspan in aging are tantamount. Diet and nutrition are important determinants of the aging trajectory. Plant-based diets that provide bioactive phytonutrients may
Externí odkaz:
https://doaj.org/article/8e60cd36ccfe492db0046546fd1f5a72
Autor:
Deniz Heydarian, Matthew Flavel, Mihiri Munasinghe, Abdullah Almotayri, Markandeya Jois, Jency Thomas
Publikováno v:
Journal of Ageing and Longevity, Vol 4, Iss 1, Pp 15-27 (2024)
Previous research has established that polyphenols increase lifespan and stress resistance in C. elegans. However, the effects of timing of exposure on the extension of lifespan and the mechanisms involved are not completely understood. This study ai
Externí odkaz:
https://doaj.org/article/c93513472374491ea6a817ac983ae604
Autor:
Luke Slade, Shelby E. Bollen, Joseph J. Bass, Bethan E. Phillips, Kenneth Smith, Daniel J. Wilkinson, Nathaniel J. Szewczyk, Philip J. Atherton, Timothy Etheridge
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 6, Pp 2613-2622 (2023)
Abstract Background Age‐related muscle decline (sarcopenia) associates with numerous health risk factors and poor quality of life. Drugs that counter sarcopenia without harmful side effects are lacking, and repurposing existing pharmaceuticals coul
Externí odkaz:
https://doaj.org/article/6bd10457f3044741bde9ad6c45e62c4f