Long-term exposure to house dust mites accelerates lung cancer development in mice

Autor: Dongjie Wang, Wen Li, Natalie Albasha, Lindsey Griffin, Han Chang, Lauren Amaya, Sneha Ganguly, Liping Zeng, Bora Keum, José M. González-Navajas, Matt Levin, Zohreh AkhavanAghdam, Helen Snyder, David Schwartz, Ailin Tao, Laela M. Boosherhri, Hal M. Hoffman, Michael Rose, Monica Valeria Estrada, Nissi Varki, Scott Herdman, Maripat Corr, Nicholas J. G. Webster, Eyal Raz, Samuel Bertin

Publikováno v: Journal of experimental & clinical cancer research : CR, vol 42, iss 1

Background Individuals with certain chronic inflammatory lung diseases have a higher risk of developing lung cancer (LC). However, the underlying mechanisms remain largely unknown. Here, we hypothesized that chronic exposure to house dust mites (HDM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a89a0979e8749c0a363e6284bc9232f
https://escholarship.org/uc/item/5jf8c6w3

Effects of a Lpg Stove and Fuel Intervention on Adverse Maternal Outcomes: A Multi-Country Randomized Controlled Trial Conducted by the Household Air Pollution Intervention Network (Hapin)

Autor: Younger, Ashley, Alkon, Abbey, Harknett, Kristen, Kirby, Miles A, Elon, Lisa, Lovvorn, Amy E, Wang, Jiantong, Ye, Wenlu, Diaz-Artiga, Anaité, McCracken, John P, Castañaza Gonzalez, Adly, Monroy Alarcon, Libny, Mukeshimana, Alexie, Rosa, Ghislaine, Chiang, Marilu, Balakrishnan, Kalpana, Garg, Sarada S, Pillarisetti, Ajay, Piedrahita, Ricardo, Johnson, Michael, Craik, Rachel, Papageorghiou, Aris T, Toenjes, Ashley, Quinn, Ashlinn, Williams, Kendra N, Underhill, Lindsay, Chang, Howard H, Naeher, Luke P, Rosenthal, Joshua, Checkley, William, Peel, Jennifer L, Clasen, Thomas F, Thompson, Lisa M, HAPIN investigators

Household air pollution from solid cooking fuel use during gestation has been associated with adverse pregnancy and birth outcomes. The Household Air Pollution Intervention Network (HAPIN) trial was a randomized controlled trial of free liquefied pet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfcaa48cab9d6513f354b8cc65aebe7
https://doi.org/10.2139/ssrn.4428854

Biomass Smoke Exposure and Atopy among Young Children in the Western Highlands of Guatemala: A Prospective Cohort Study

Autor: Wenxin Lu, Laura Ann Wang, Jennifer Mann, Alisa Jenny, Carolina Romero, Andrea Kuster, Eduardo Canuz, Ajay Pillarisetti, Kirk R. Smith, John Balmes, Lisa Thompson

Publikováno v: International journal of environmental research and public health, vol 19, iss 21
International Journal of Environmental Research and Public Health; Volume 19; Issue 21; Pages: 14064

Women and children in rural regions of low-income countries are exposed to high levels of household air pollution (HAP) as they traditionally tend to household chores such as cooking with biomass fuels. Early life exposure to air pollution is associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf7d92a4f9815c9065bcd70b9ea9628
https://escholarship.org/uc/item/00n1r7rt

Single-Cell RNA-Seq Analysis Reveals Lung Epithelial Cell Type-Specific Responses to HDM and Regulation by Tet1

Autor: Tao Zhu, Anthony P. Brown, Lucy P. Cai, Gerald Quon, Hong Ji

Publikováno v: Genes, vol 13, iss 5
Genes; Volume 13; Issue 5; Pages: 880

Tet1 protects against house dust mite (HDM)-induced lung inflammation in mice and alters the lung methylome and transcriptome. In order to explore the role of Tet1 in individual lung epithelial cell types in HDM-induced inflammation, we established a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24936397b920fd8f37a8aa8ddb5ae5c0
https://escholarship.org/uc/item/8zq1517f

Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ

Autor: Juan Aguilera, Xiaorui Han, Shu Cao, John Balmes, Fred Lurmann, Tim Tyner, Liza Lutzker, Elizabeth Noth, S. Katharine Hammond, Vanitha Sampath, Trevor Burt, P. J. Utz, Purvesh Khatri, Nima Aghaeepour, Holden Maecker, Mary Prunicki, Kari Nadeau

Publikováno v: Clinical epigenetics, vol 14, iss 1

BackgroundAmbient air pollutant (AAP) exposure is associated with adverse pregnancy outcomes, such as preeclampsia, preterm labor, and low birth weight. Previous studies have shown methylation of immune genes associate with exposure to air pollutants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f87d9467dee863a8111d019e962ce3a
https://doi.org/10.1186/s13148-022-01254-2