Výsledky vyhledávání - "Hea-Jin Park"

Akademický článek

Tanshinone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model

Autor: Julie H. Jeon, Erin E. Kaiser, Elizabeth S. Waters, Xueyuan Yang, Jeferson M. Lourenco, Madison M. Fagan, Kelly M. Scheulin, Sydney E. Sneed, Soo K. Shin, Holly A. Kinder, Anil Kumar, Simon R. Platt, Jeongyoun Ahn, Kylee J. Duberstein, Michael J. Rothrock, Todd R. Callaway, Jin Xie, Franklin D. West, Hea Jin Park

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Impaired gut homeostasis is associated with stroke often presenting with leaky gut syndrome and increased gut, brain, and systemic inflammation that further exacerbates brain damage. We previously reported that intracisternal administration

Externí odkaz: https://doaj.org/article/6d469ec2e68b470295666853b023f23d

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Akademický článek

Fecal microbial transplantation limits neural injury severity and functional deficits in a pediatric piglet traumatic brain injury model

Autor: Madison M. Fagan, Christina B. Welch, Kelly M. Scheulin, Sydney E. Sneed, Julie H. Jeon, Morgane E. Golan, Savannah R. Cheek, Deborah A. Barany, Georg Oeltzschner, Todd R. Callaway, Qun Zhao, Hea Jin Park, Jeferson M. Lourenco, Kylee J. Duberstein, Franklin D. West

Publikováno v: Frontiers in Neuroscience, Vol 17 (2023)

Pediatric traumatic brain injury (TBI) is a leading cause of death and disability in children. Due to bidirectional communication between the brain and gut microbial population, introduction of key gut bacteria may mitigate critical TBI-induced secon

Externí odkaz: https://doaj.org/article/891e7dc5bd3149b0b071b4984dff329a

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Akademický článek

Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke

Autor: Elizabeth S. Waters, Erin E. Kaiser, Xueyuan Yang, Madison M. Fagan, Kelly M. Scheulin, Julie H. Jeon, Soo K. Shin, Holly A. Kinder, Anil Kumar, Simon R. Platt, Kylee J. Duberstein, Hea Jin Park, Jin Xie, Franklin D. West

Publikováno v: IBRO Neuroscience Reports, Vol 10, Iss , Pp 18-30 (2021)

Background: The absolute number of new stroke patients is annually increasing and there still remains only a few Food and Drug Administration (FDA) approved treatments with significant limitations available to patients. Tanshinone IIA (Tan IIA) is a

Externí odkaz: https://doaj.org/article/d28f059093814129a866cebfb77646c7

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Akademický článek

Changes in Oral Microbial Diversity in a Piglet Model of Traumatic Brain Injury

Autor: Julie Heejin Jeon, Jeferson M. Lourenco, Madison M. Fagan, Christina B. Welch, Sydney E. Sneed, Stephanie Dubrof, Kylee J. Duberstein, Todd R. Callaway, Franklin D. West, Hea Jin Park

Publikováno v: Brain Sciences, Vol 12, Iss 8, p 1111 (2022)

Dynamic changes in the oral microbiome have gained attention due to their potential diagnostic role in neurological diseases such as Alzheimer’s disease and Parkinson’s disease. Traumatic brain injury (TBI) is a leading cause of death and disabil

Externí odkaz: https://doaj.org/article/27a6e5dab53748289ebd1a7a6b7330c1

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Akademický článek

Dynamic Changes in the Gut Microbiome at the Acute Stage of Ischemic Stroke in a Pig Model

Autor: Julie Jeon, Jeferson Lourenco, Erin E. Kaiser, Elizabeth S. Waters, Kelly M. Scheulin, Xi Fang, Holly A. Kinder, Simon R. Platt, Michael J. Rothrock, Todd R. Callaway, Franklin D. West, Hea Jin Park

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Stroke is a major cause of death and long-term disability affecting seven million adults in the United States each year. Recently, it has been demonstrated that neurological diseases, associated pathology, and susceptibility changes correlated with c

Externí odkaz: https://doaj.org/article/e736de15437f4134a7ba7b9e7d32cd40

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