Zobrazeno 1 - 10 of 157 pro vyhledávání: '"Hea Ok Kim"'
1
Structure–activity relationships of 2′-modified-4′-selenoarabinofuranosyl-pyrimidines as anticancer agents
Autor: Varughese Alexander, Jungwon Choi, Sang Kook Lee, Jin-Hee Kim, Jayoung Song, Jinha Yu, Hyuk Woo Lee, Jung Hee Choi, Hea Ok Kim, Lak Shin Jeong
Publikováno v: European Journal of Medicinal Chemistry. 83:208-225
Based on the potent anticancer activity of the D-arabino-configured cytosine nucleoside ara-C, novel 2′-substituted-4′-selenoarabinofuranosyl pyrimidines 3a–3u, comprising azido, fluoro, and hydroxyl substituents at C-2′ were designed, synthe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81ebb41445c97b348f21ec89332658e
https://doi.org/10.1016/j.ejmech.2014.06.031
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2
Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N6-Substituted-(N)-Methanocarba-nucleosides as A3 Adenosine Receptor Antagonists and Partial Agonists
Autor: Jakyung Yoo, Khai Phan, Inah Hwang, Zhan Guo Gao, Hunjoo Ha, Sun Choi, Akshata Nayak, Girish Chandra, Kyunglim Kim, Steven M. Moss, Minghua Cui, Pramod K. Sahu, Kuldeep K. Roy, Kenneth A. Jacobson, Lak Shin Jeong, Hea Ok Kim, Xiyan Hou, Yoonji Lee
Publikováno v: Journal of Medicinal Chemistry
Truncated N(6)-substituted-(N)-methanocarba-adenosine derivatives with 2-hexynyl substitution were synthesized to examine parallels with corresponding 4'-thioadenosines. Hydrophobic N(6) and/or C2 substituents were tolerated in A3AR binding, but only
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec19610652a10e889679b08736b955f7
http://europepmc.org/articles/PMC3954500
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3
Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity
Autor: Won Jun Choi, Akshata Nayak, Varughese Alexander, Long Xuan Zhao, Chang H. Ahn, Hea Ok Kim, Lak Shin Jeong, Young Bok Lee, Sang Kook Lee, Girish Chandra, Jin-Hee Kim, Hwa-Jin Chung, Hyuk Woo Lee, Mahesh S. Majik
Publikováno v: Journal of Medicinal Chemistry. 55:4521-4525
On the basis of the potent biological activity of cyclopentenyl-pyrimidines, fluorocyclopentenyl-pyrimidines were designed and synthesized from D-ribose. Among these, the cytosine derivative 5a showed highly potent antigrowth effects in a broad range
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a77c3dae6ab20479f2f63137bfe68e
https://doi.org/10.1021/jm3004009
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4
Stereoselective synthesis and anti-HCV activity of conformationally restricted 2′-C-substituted carbanucleosides
Autor: Yun Jung Ko, Hea Ok Kim, Young Hoon Jung, Hyo Jung Koh, Hyuk Woo Lee, Lak Shin Jeong, Won Jun Choi, Hyung Ryong Moon, Girish Chandra
Publikováno v: Tetrahedron. 68:1253-1261
Conformationally restricted 2′-C-azido-, hydroxy- and fluoromethyl-carbanucleosides 4b–f were efficiently synthesized via the stereoselective conversion of ketone 7 to epoxide 14, followed by the stereoselective opening of the epoxide with nucleo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26ce36979a982642f6b21b7b14f3aefa
https://doi.org/10.1016/j.tet.2011.11.052
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5
Discovery of A New Human A2A Adenosine Receptor Agonist, Truncated 2-Hexynyl-4′-thioadenosine
Autor: Kenneth A. Jacobson, Lak Shin Jeong, Lena S. Yoo, Zhan Guo Gao, Jin Hee Lee, Hea Ok Kim, Xiyan Hou, Seul Gi Park, Sun Choi, Kyunglim Kim, Varughese Alexander
Publikováno v: ACS Medicinal Chemistry Letters. 1:516-520
The truncated C2- and C8-substituted 4′-thioadenosine derivatives 4a−d were synthesized from d-mannose, using palladium-catalyzed cross-coupling reactions as key steps. In this study, an A3 adenosine receptor (AR) antagonist, truncated 4′-thioa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0522ac67f4f70c3510497f047fd7a498
https://doi.org/10.1021/ml1001823
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6
A New DNA Building Block, 4′-Selenothymidine: Synthesis and Modification to 4′-Seleno-AZT as a Potential Anti-HIV Agent
Autor: Girish Chandra, Won Jun Choi, Jungwon Choi, Ji Hye Jeon, Lak Shin Jeong, Jeongha Chun, Dilip K. Tosh, Varughese Alexander, Hyuk Woo Lee, Hea Ok Kim
Publikováno v: Organic Letters. 12:2242-2245
The first synthesis of 4'-selenothymidine (1), a novel DNA building block, and 4'-seleno-AZT (2) was accomplished from 2-deoxy-d-ribose via stereoselective formation of 2-deoxy-4-seleno-d-furanose 17 and a Pummerer-type base condensation as key steps
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d264342fed0c30a4bd37e8352ea0730
https://doi.org/10.1021/ol1005906
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7
Design and synthesis of N6-substituted-4′-thioadenosine-5′-uronamides as potent and selective human A3 adenosine receptor agonists
Autor: Hea Ok Kim, Young Hoon Jung, Hyuk Woo Lee, Amit Patel, Won Jun Choi, Lalc Shin Jeong, Kenneth A. Jacobson, Moshe Chinn, Zhan-Guo Gao, Hyung Ryong Moon
Publikováno v: Bioorganic & Medicinal Chemistry. 17:8003-8011
On the basis of a bioisosteric rationale, 4'-thionucleoside analogues of IB-MECA (N(6)-(3-Iodo-benzyl)-9-(5'-methylaminocarbonyl-beta-d-ribofuranosyl)adenine), which is a potent and selective A(3) adenosine receptor (AR) agonist, were synthesized fro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99522bfee393b8479fdc542dbfb1cdff
https://doi.org/10.1016/j.bmc.2009.10.011
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8
Structure–activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists
Autor: Kenneth A. Jacobson, Lak Shin Jeong, Moshe Chinn, Cara L. Heller, Shantanu Pal, Sang Kook Lee, Seung Ah Choe, Hea Ok Kim, Won Jun Choi, Zhan-Guo Gao, Xiyan Hou
Publikováno v: Bioorganic & Medicinal Chemistry. 17:3733-3738
On the basis of potent and selective binding affinity of truncated 4'-thioadenosine derivatives at the human A(3) adenosine receptor (AR), their bioisosteric 4'-oxo derivatives were designed and synthesized from commercially available 2,3-O-isopropyl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43aa025aaa29d4deef99c4ea7de9c6ca
https://doi.org/10.1016/j.bmc.2009.03.034
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9
Structure−Activity Relationships of Truncated d- and l-4′-Thioadenosine Derivatives as Species-Independent A3 Adenosine Receptor Antagonists
Autor: Xiyan Hou, Hyung Ryong Moon, Dilip K. Tosh, Seung Ah Choe, Zhan-Guo Gao, Hea Ok Kim, Wonjun Choi, Sang Kook Lee, Kenneth A. Jacobson, Lak Shin Jeong, Athena M. Klutz, Hyuk Woo Lee, Shantanu Pal
Publikováno v: Journal of Medicinal Chemistry. 51:6609-6613
Novel D- and l-4'-thioadenosine derivatives lacking the 4'-hydroxymethyl moiety were synthesized, starting from d-mannose and d-gulonic gamma-lactone, respectively, as potent and selective species-independent A 3 adenosine receptor (AR) antagonists.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9844401051eb4192ec9d8f8253f6d47f
https://doi.org/10.1021/jm8008647
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10
Synthesis of 3′-Acetamidoadenosine Derivatives as Potential A3Adenosine Receptor Agonists
Autor: Zhan-Guo Gao, Tae Kyung Kang, Won Jun Choi, Moon Woo Chun, Kenneth A. Jacobson, Lak Shin Jeong, Sung Wook Choi, Hea Ok Kim
Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 27:408-420
On the basis of high binding affinity of 3'-aminoadenosine derivatives 2b at the human A3 adenosine receptor (AR), 3'-acetamidoadenosine derivatives 3a–e were synthesized from 1,2:5,6-di-O-isopropylidene-d-glucose via stereoselective hydroboration
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98309ebd05b6abd7085eb4af00138c6a
https://doi.org/10.1080/15257770801944436
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