Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Hea‐Young Park Choo"'
Publikováno v:
Molecules, Vol 27, Iss 9, p 2696 (2022)
Development of small molecules that inhibit inflammatory cytokines is a desirable strategy for the treatment of inflammatory diseases such as rheumatoid arthritis (RA). Following up a previous study, we synthesized 10 novel compounds with a 2,5-diami
Externí odkaz:
https://doaj.org/article/97ad39598fe1400bb6e4518f32ae5405
Autor:
Jaeok Lee, Song Wha Chae, LianJi Ma, So Yeon Lim, Sarah Alnajjar, Hea-Young Park Choo, Hwa Jeong Lee, Sandy Jeong Rhie
Publikováno v:
Pharmaceutics, Vol 11, Iss 11, p 593 (2019)
P-glycoprotein (P-gp) is known to be involved in multidrug resistance (MDR) and modulation of pharmacokinetic (PK) profiles of substrate drugs. Here, we studied the effects of synthesized ferulic acid (FA) derivatives on P-gp function in vitro and ex
Externí odkaz:
https://doaj.org/article/dff56457f17d4c0e907452c90b61b299
Autor:
Jaeok Lee, Song Wha Chae, A Reum Oh, Ji Hye Yoo, Hea-Young Park Choo, Sandy Jeong Rhie, Hwa Jeong Lee
Publikováno v:
Pharmaceutics, Vol 11, Iss 1, p 23 (2019)
Paclitaxel (PTX) is an anticancer agent that is used to treat many cancers but it has a very low oral bioavailability due, at least in part, to the drug efflux transporter, P-glycoprotein (P-gp). Therefore, this study was performed to enhance oral bi
Externí odkaz:
https://doaj.org/article/deaeafddfe854e86a00acfe73355060a
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5331
LPS induces inflammatory cytokines, including IL-1β, IL-6, and TNF-α, and causes an inflammatory response. The development of small molecules that have suppressive effect on those inflammatory cytokines is a desirable strategy for the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb640e5bfe6201615ead9f79cffbef6
https://doi.org/10.3390/ijms23105331
https://doi.org/10.3390/ijms23105331
Autor:
Sandy Jeong Rhie, Song Wha Chae, Jaeok Lee, Hea Young Park Choo, Hwa Jeong Lee, A. Reum Oh, Ji Hye Yoo
Publikováno v:
Pharmaceutics, Vol 11, Iss 1, p 23 (2019)
Pharmaceutics
Volume 11
Issue 1
Pharmaceutics
Volume 11
Issue 1
Paclitaxel (PTX) is an anticancer agent that is used to treat many cancers but it has a very low oral bioavailability due, at least in part, to the drug efflux transporter, P-glycoprotein (P-gp). Therefore, this study was performed to enhance oral bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f2aa8921741e4352a551e98db20aee
http://www.mdpi.com/1999-4923/11/1/23
http://www.mdpi.com/1999-4923/11/1/23
Publikováno v:
Molecular Medicine Reports.
Mast cells are central regulators of allergic inflammation that function by releasing various proallergic inflammatory mediators, including histamine, eicosanoids and proinflammatory cytokines. Occasionally, bacterial infections may initiate or worse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad476ac0d714efe95adaf7d487b304d
https://doi.org/10.3892/mmr.2018.8719
https://doi.org/10.3892/mmr.2018.8719
Publikováno v:
Archives of Pharmacal Research. 39:178-190
Osteoporosis is a disorder in which bone mass decreases and is responsible for many degenerative bone diseases. The excessive formation and activity of osteoclasts results in pathological disorders of the bone. Receptor Activator of Nuclear Factor κ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db41fbab17a4bb548d9402c375824aef
https://doi.org/10.1007/s12272-015-0672-x
https://doi.org/10.1007/s12272-015-0672-x
Publikováno v:
Bulletin of the Korean Chemical Society. 36:2290-2297
Blockage of voltage-gated sodium channels is used to treat neuropathic pain which is chronic and can become debilitating. Sodium channels Nav1.7–1.9 are especially attractive targets for drug discovery because of the broad therapeutic potential of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffae0d8be975eb48544306561755d936
https://doi.org/10.1002/bkcs.10446
https://doi.org/10.1002/bkcs.10446
Autor:
Hea-Young Park Choo, Sang Nae Cho, Taegwon Oh, Euna Yoo, Dae-Kee Kim, Faisal Hayat, Yhun Yhung Sheen
Publikováno v:
Bulletin of the Korean Chemical Society. 36:43-51
1,2,4-Triazoles exert antimycobacterial activity by inhibiting the cell wall biosynthesis. In an attempt to developing lead compounds exhibiting antitubercular activities, a series of 1,2,4-triazole derivatives were synthesized by introducing various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec0918d1d63c899dc5f57f53ebe97e0f
https://doi.org/10.1002/bkcs.10009
https://doi.org/10.1002/bkcs.10009
Autor:
Sera Oh, Yeon Ji Oh, Hee Yeon Won, Eun Sook Hwang, Darong Kim, Mi Gyeong Jeong, Eun Jung Jang, Hea Young Park Choo, Hana Jeong
Publikováno v:
SCIENTIFIC REPORTS(7)
Scientific Reports
Scientific Reports
Interferon-γ (IFN-γ), a critical inflammatory cytokine, is primarily produced by T helper 1 (Th1) cells and accelerates the pathogenesis of inflammatory colitis. Pharmacological suppression of IFN-γ production attenuates dysregulated inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd80b1c3e2148e6e90b23fbde3710da
http://open-repository.kisti.re.kr/cube/handle/open_repository/482497.do
http://open-repository.kisti.re.kr/cube/handle/open_repository/482497.do
