Zobrazeno 1 - 10
of 75
pro vyhledávání: '"He-zuo Lü"'
Autor:
Jing-Lu Li, Gui-Qiang Fu, Yang-Yang Wang, Ming-Ming Bian, Yao-Mei Xu, Lin Zhang, Yu-Qing Chen, Nan Zhang, Shu-Qin Ding, Rui Wang, Rui Fang, Jie Tang, Jian-Guo Hu, He-Zuo Lü
Publikováno v:
PeerJ, Vol 11, p e14929 (2023)
Background Following spinal cord injury (SCI), a large number of peripheral monocytes infiltrate into the lesion area and differentiate into macrophages (Mø). These monocyte-derived Mø are very difficult to distinguish from the local activated micr
Externí odkaz:
https://doaj.org/article/9c8620617c1b4f0cb3d572de2619f0bb
Autor:
Qi Qi, Xiao-Xuan Wang, Jing-Lu Li, Yu-Qing Chen, Jian-Rong Chang, Jin Xi, He-Zuo Lü, Yu-Xin Zhang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Proinflammatory immune cell subsets constitute the majority in the local microenvironment after spinal cord injury (SCI), leading to secondary pathological injury. Previous studies have demonstrated that inflammasomes act as an important part of the
Externí odkaz:
https://doaj.org/article/9592eac350f14493b52c63a25af8d00c
Autor:
Jing Chen, Yu-Qing Chen, Yu-Jiao Shi, Shu-Qin Ding, Lin Shen, Rui Wang, Qi-Yi Wang, Cheng Zha, Hai Ding, Jian-Guo Hu, He-Zuo Lü
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 9, Pp 1836-1847 (2021)
Inflammation is a major cause of neuronal injury after spinal cord injury. We hypothesized that inhibiting caspase-1 activation may reduce neuroinflammation after spinal cord injury, thus producing a protective effect in the injured spinal cord. A mo
Externí odkaz:
https://doaj.org/article/118f003fb4354b48ae1e667daa7ba168
Autor:
Yu-Qing Chen, Sai-Nan Wang, Yu-Jiao Shi, Jing Chen, Shu-Qin Ding, Jie Tang, Lin Shen, Rui Wang, Hai Ding, Jian-Guo Hu, He-Zuo Lü
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-18 (2020)
Abstract Background After spinal cord injury (SCI), destructive immune cell subsets are dominant in the local microenvironment, which are the important mechanism of injury. Studies have shown that inflammasomes play an important role in the inflammat
Externí odkaz:
https://doaj.org/article/a51e96b6c7b649b582219571efe11df0
Autor:
Sai-Nan Wang, Xue-Yan Guo, Jie Tang, Shu-Qin Ding, Lin Shen, Rui Wang, Shan-Feng Ma, Jian-Guo Hu, He-Zuo Lü
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 3, Pp 542-552 (2019)
In traumatic brain injury, absent in melanoma 2 (AIM2) has been demonstrated to be involved in pyroptotic neuronal cell death. Although the pathophysiological mechanism of spinal cord injury is similar to that of brain injury, the expression and cell
Externí odkaz:
https://doaj.org/article/29e2d5ba6b924690b4f7017a6a07c61f
Publikováno v:
PeerJ, Vol 8, p e8367 (2020)
Background Recent studies have found that probenecid has neuroprotective and reparative effects on central nervous system injuries. However, its effect on genome-wide transcription in acute spinal cord injury (SCI) remains unknown. In the present stu
Externí odkaz:
https://doaj.org/article/c624dc50327d4e86be8d8817a3ff853d
Autor:
Xue-Yan Guo, Fei-Xiang Duan, Jing Chen, Ying Wang, Rui Wang, Lin Shen, Qi Qi, Zhi-Quan Jiang, An-You Zhu, Jin Xi, He-Zuo Lü, Jian-Guo Hu
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Previous studies by our group have demonstrated that the transplantation of exogenous platelet-derived growth factor (PDGF)-AA-overexpressing oligodendrocyte progenitor cells (OPCs) promotes tissue repair and recovery of neurological function in a ra
Externí odkaz:
https://doaj.org/article/8b2de2f738114fc5a8ed6a15cb0a8690
Autor:
Xiu-Mei Xie, Ling-Ling Shi, Lin Shen, Rui Wang, Qi Qi, Qi-Yi Wang, Lun-Jun Zhang, He-Zuo Lü, Jian-Guo Hu
Publikováno v:
Neurobiology of Disease, Vol 94, Iss , Pp 196-204 (2016)
Oligodendrocyte (OL) replacement is a promising treatment strategy for spinal cord injury (SCI). However, the poor survival of transplanted OLs or their precursors and inhibition of axonal regeneration are two major challenges with this approach. Our
Externí odkaz:
https://doaj.org/article/a849f2f3225a47cfbd8bed665e6172ca
Autor:
Xiao-jian Cao, Shi-qing Feng, Chang-feng Fu, Kai Gao, Jia-song Guo, Xiao-dong Guo, Xi-jing He, Zi-wei Huang, Zhong-hai Li, Ling Liu, Rong-han Liu, He-zuo Lü, Xi-fan Mei, Bin Ning, Guang-zhi Ning, Chang-hui Qian, Jie Qin, Yan-zhen Qu, Saijilafu, Bo Shi, Tao Sui, Tian-sheng Sun, Jian Wang, Jing-kun Wen, Jian Xiao, Bin Xu, Hai-dong Xu, Pan-pan Yu, Zhi-cheng Zhang, Yong Zhou, Yu-long Zhou
Publikováno v:
Neural Regeneration Research, Vol 10, Iss 12, Pp 1953-1975 (2015)
Externí odkaz:
https://doaj.org/article/31b536dc27d64755a2799d2c10f3b370
Autor:
He-Zuo Lü, Jiaxin Xu, Ruina Hu, Yu-Jiao Shi, Xue Song, Zhen Ren, Fengzhi Li, Xiao-Xin Cheng, Jian-Guo Hu, Qi Qi
Publikováno v:
Cell Cycle. 20:661-675
Neurodegenerative disorders, including spinal cord injury (SCI), result in oxidative stress-induced cell damage. Morroniside (MR), a major active ingredient of the Chinese herb Shan Zhu Yu, has been shown to ameliorate oxidative stress and inflammato