Zobrazeno 1 - 6
of 6
pro vyhledávání: '"He G. Sun"'
Publikováno v:
Nature
Oxetanocin A (OXT-A) is a potent antitumour, antiviral and antibacterial compound. Biosynthesis of OXT-A has been linked to a plasmid-borne Bacillus megaterium gene cluster that contains four genes: oxsA, oxsB, oxrA and oxrB. Here we show that both t
Autor:
Mei-Yeh Jade Lu, He G. Sun, Jeng Yi Li, Steven E. Ealick, Albert Ou, Tsunglin Liu, Hung-wen Liu, Eita Sasaki, Xuan Zhang, Yu-Hsiang Chen
Publikováno v:
Nature. 510:427-431
Sulphur is an essential element for life and is ubiquitous in living systems. Yet how the sulphur atom is incorporated into many sulphur-containing secondary metabolites is poorly understood. For bond formation between carbon and sulphur in primary m
Uridine 5'-diphosphate-5-fluorogalactopyranose (UDP-5F-Galp, 7) was synthesized, and its effect on UDP-Galp mutase (UGM) was investigated. UGM facilitated the hydrolysis of 7 to yield UDP and 5-oxogalactose (24), but no 11 was detected. (19)F NMR and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb34554232a640c0dc5eb20b67e30948
https://europepmc.org/articles/PMC5474323/
https://europepmc.org/articles/PMC5474323/
Autor:
Tianzhu Zang, Joshua J. Klaene, Shujia Dai, Zhaohui Sunny Zhou, Joshua F. Alfaro, Steven Clarke, He G. Sun, Barry L. Karger, Jonathan D. Lowenson, Laura A. Gillies, Byung Ju Kim
Publikováno v:
Analytical Chemistry. 80:3882-3889
Isoaspartate formation is a ubiquitous post-translation modification arising from spontaneous asparagine deamidation or aspartate isomerization. The formation of isoaspartate inserts a methylene group into the protein backbone, generating a "kink", a
UDP-galactopyranose mutase (UGM) requires reduced FAD (FAD(red)) to catalyze the reversible interconversion of UDP-galactopyranose (UDP-Galp) and UDP-galactofuranose (UDP-Galf). Recent structural and mechanistic studies of UGM have provided evidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d6c7dcb4aef2e91e4c86973cc37662
https://europepmc.org/articles/PMC3281622/
https://europepmc.org/articles/PMC3281622/
Publikováno v:
Journal of the American Chemical Society. 132(11)
S-adenosylmethionine (AdoMet or SAM)-dependent methyltransferases belong to a large and diverse family of group-transfer enzymes that perform vital biological functions on a host of substrates. Despite the progress in genomics, structural proteomics,