Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.

Autor: Kaminishi, Tatsuya, Schedlbauer, Andreas, Fabbretti, Attilio, Brandi, Letizia, Ochoa Lizarralde, Borja, He, Cheng-Guang, Milon, Pohl, Connell, Sean R, Gualerzi, Claudio O, Fucini, Paola

Publikováno v: Universidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPC.

Hygromycin A (HygA) binds to the large ribosomal subunit and inhibits its peptidyl transferase (PT) activity. The presented structural and biochemical data indicate that HygA does not interfere with the initial binding of aminoacyl-tRNA to the A site

Externí odkaz: http://hdl.handle.net/10757/608247

The Ribosome as a Switchboard for Bacterial Stress Response

Autor: He Cheng-Guang, Claudio Orlando Gualerzi

Publikováno v: Frontiers in Microbiology, Vol 11 (2021)

As free-living organisms, bacteria are subject to continuous, numerous and occasionally drastic environmental changes to which they respond with various mechanisms which enable them to adapt to the new conditions so as to survive. Here we describe th

Externí odkaz: https://doaj.org/article/3c1382c7a8854613b22c30097747bdf2

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Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.

Autor: Kaminishi T; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Bizkaia, 48160 Derio, Bizkaia, Spain., Schedlbauer A; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Bizkaia, 48160 Derio, Bizkaia, Spain., Fabbretti A; Laboratory of Genetics, Department of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy., Brandi L; Laboratory of Genetics, Department of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy., Ochoa-Lizarralde B; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Bizkaia, 48160 Derio, Bizkaia, Spain., He CG; Laboratory of Genetics, Department of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy., Milón P; School of Medicine, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas - UPC, Lima, L-33, Perú, Connell SR; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Bizkaia, 48160 Derio, Bizkaia, Spain IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain sean.connell@gmail.com., Gualerzi CO; Laboratory of Genetics, Department of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy claudio.gualerzi@unicam.it., Fucini P; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Bizkaia, 48160 Derio, Bizkaia, Spain IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain pfucini@gmail.com.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2015 Nov 16; Vol. 43 (20), pp. 10015-25. Date of Electronic Publication: 2015 Oct 12.