Zobrazeno 1 - 10
of 4 165
pro vyhledávání: '"Hdac6"'
Autor:
Yi-Ting Yang, Bin Yan, Li-Na Guo, Miao Liu, Yu-Hua Li, Zhi-Yu Shao, Hua Diao, Su-Ying Liu, He-Guo Yu
Publikováno v:
Asian Journal of Andrology, Vol 26, Iss 5, Pp 490-499 (2024)
Male infertility is a global issue caused by poor sperm quality, particularly motility. Enhancement of the sperm quality may improve the fertilization rate in assisted reproductive technology (ART) treatment. Scriptaid, with a novel human sperm motil
Externí odkaz:
https://doaj.org/article/e6e26ac01c9e45d9817757f657aa6304
Autor:
Liqun Xu, Lijun Zhang, Gaozhi Li, Xiaoyan Zhang, Quan Sun, Zebing Hu, Xinsheng Cao, Yixuan Wang, Fei Shi, Shu Zhang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Mechanical unloading-induced bone loss threatens prolonged spaceflight and human health. Recent studies have confirmed that osteoporosis is associated with a significant reduction in bone microvessels, but the relationship between
Externí odkaz:
https://doaj.org/article/cd8749fa61694f23a28f0c2de45b1d90
Autor:
Debasmita Naik, Arunasree M. Kalle
Publikováno v:
Non-coding RNA Research, Vol 9, Iss 3, Pp 732-743 (2024)
Cervical cancer, a leading global cause of female mortality, exhibits diverse molecular aberrations influencing gene expression and signaling pathways. Epigenetic factors, including histone deacetylases (HDACs) such as HDAC8 and HDAC6, along with mic
Externí odkaz:
https://doaj.org/article/0bad0d41f1d3492fbedfcc02058dd15e
Autor:
Arpita Mukherjee, Mahadeb Lo, Pritam Chandra, Ratul Datta Chaudhuri, Papiya De, Shanta Dutta, Mamta Chawla-Sarkar
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-16 (2024)
Abstract Background The global outbreak of COVID-19 caused by the SARS-CoV-2 has led to millions of deaths. This unanticipated emergency has prompted virologists across the globe to delve deeper into the intricate dynamicity of the host-virus interfa
Externí odkaz:
https://doaj.org/article/e7f6f012a3e441fa92f012147b900a1c
Autor:
Nasim Bahram Sangani, Jarno Koetsier, Jonathan Mélius, Martina Kutmon, Friederike Ehrhart, Chris T. Evelo, Leopold M. G. Curfs, Chris P. Reutelingsperger, Lars M. T. Eijssen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Due to its involvement in physiological and pathological processes, histone deacetylase 6 (HDAC6) is considered a promising pharmaceutical target for several neurological manifestations. However, the exact regulatory role of HDAC6 in the cen
Externí odkaz:
https://doaj.org/article/df6e6d5918da4d449dba8e00be5fbf47
Autor:
Tetsuro Tago, Jun Toyohara
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract Background Histone deacetylase 6 (HDAC6) is an emerging target for the treatment and diagnosis of proteinopathies. [18F]FSW-100 was recently developed as a promising brain-penetrating radioligand for HDAC6 PET imaging and the process validat
Externí odkaz:
https://doaj.org/article/f1c37a545bdb4095ae0b9297ef36478b
Autor:
Yunting Shao, Pir Tariq Shah, Qisheng Su, Shanhu Li, Fang Huang, Jun Wang, Peng Wang, Chengjun Wu
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
ObjectiveHigh-risk human papillomavirus (HPV) is a carcinogenic virus associated with nearly all cases of cervical cancer, as well as an increasing number of anal and oral cancers. The two carcinogenic proteins of HPV, E6 and E7, can immortalize kera
Externí odkaz:
https://doaj.org/article/34c36f614665498385bd6d68e70bd827
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35020- (2024)
Histone deacetylase 6 (HDAC6, Class IIb) is a promising target for anticancer drugs. So far, few nonselective HDAC inhibitors have received regulatory approval as anticancer agents. However, they are associated with cell toxicity. Thus, isoform-selec
Externí odkaz:
https://doaj.org/article/8e8346387d1f4bd9b37223dccb428c0b
Autor:
Tian Qin, Chengjun Li, Yan Xu, Yiming Qin, Yuxin Jin, Rundong He, Zixiang Luo, Jinyun Zhao, Chunyue Duan, Hongbin Lu, Yong Cao, Jianzhong Hu
Publikováno v:
Bioactive Materials, Vol 33, Iss , Pp 424-443 (2024)
Spinal cord injury (SCI) causes severe axon damage, usually leading to permanent paraparesis, which still lacks effective regenerative therapy. Recent studies have suggested that exosomes derived from neural stem cells (NSCs) may hold promise as attr
Externí odkaz:
https://doaj.org/article/fd53cb6db84748559a1902360e776759
Publikováno v:
Renal Failure, Vol 46, Iss 2 (2024)
Aim This study explored the effect and mechanism of MAFF and HDAC6 on renal fibrosis and inflammation in lupus nephritis (LN).Methods IL-33 treated renal epithelial cells and MRL/lpr mice were respectively used for in vitro and in vivo experiments. T
Externí odkaz:
https://doaj.org/article/eac5b8ade5e64ff994b50c26d4b9dbe8