The 'Invisible Enemy' SARS-CoV-2: Viral Spread and Drug Treatment

Autor: Alina Tanase, Aniko Manea, Alexandra Denisa Scurtu, Lavinia Melania Bratu, Doina Chioran, Alina Dolghi, Iren Alexoi, Hazzaa AAbed, Voichita Lazureanu, Cristina Adriana Dehelean

Publikováno v: Medicina, Vol 58, Iss 2, p 261 (2022)

Nowadays, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become the main subject of the scientific medical world and all World Organizations, causing millions of deaths worldwide. In this review, we have highlighted the co

Externí odkaz: https://doaj.org/article/1453558a13e94294a9b323c8b217e4d2

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with in vivo proof.

Autor: El-Miligy MMM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Al-Kubeisi AK; Pharmacy Department, Al-Maarif University College, Ramadi, Anbar, Iraq., Nassra RA; Medical Biochemistry Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt., El-Zemity SR; Department of Chemistry and Technology of Pesticides, Faculty of Agriculture, Alexandria University, Alexandria, Egypt., Hazzaa AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Publikováno v: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2309171. Date of Electronic Publication: 2024 Jan 30.

Discovery of new pyridine-quinoline hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities.

Autor: El-Miligy MMM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Abdelaziz ME; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Fahmy SM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Ibrahim TM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt., Abu-Serie MM; Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt)., Mahran MA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Hazzaa AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Publikováno v: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2152810.

Discovery of small molecule acting as multitarget inhibitor of colorectal cancer by simultaneous blocking of the key COX-2, 5-LOX and PIM-1 kinase enzymes.

Autor: El-Miligy MMM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt. Electronic address: mostafa.elmiligy@alexu.edu.eg., Al-Kubeisi AK; Al-Qalam University College, Kirkuk 36004, Iraq., El-Zemity SR; Department of Chemistry and Technology of Pesticides, Faculty of Agriculture, Alexandria University, Alexandria 21521, Egypt., Nassra RA; Medical Biochemistry Department, Faculty of Medicine, Alexandria University, Alexandria 21131, Egypt., Abu-Serie MM; Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), Alexandria 21934, Egypt., Hazzaa AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2021 Oct; Vol. 115, pp. 105171. Date of Electronic Publication: 2021 Jul 16.