Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hazim Allos"'
Type I interferons augment regulatory T cell polarization in concert with ancillary cytokine signals
Autor:
Siawosh K. Eskandari, Hazim Allos, Jenelle M. Safadi, Ina Sulkaj, Jan S. F. Sanders, Paolo Cravedi, Irene M. Ghobrial, Stefan P. Berger, Jamil R. Azzi
Publikováno v:
Frontiers in Transplantation, Vol 2 (2023)
In the transplant community, research efforts exploring endogenous alternatives to inducing tolerogenic allo-specific immune responses are much needed. In this regard, CD4 + FoxP3+ regulatory T cells (Tregs) are appealing candidates due to their intr
Externí odkaz:
https://doaj.org/article/b50d639c88f04efb89352c7184a93f92
Autor:
Siawosh K. Eskandari, Hazim Allos, Basmah S. Al Dulaijan, Gandolina Melhem, Ina Sulkaj, Juliano B. Alhaddad, Anis J. Saad, Christa Deban, Philip Chu, John Y. Choi, Branislav Kollar, Bohdan Pomahac, Leonardo V. Riella, Stefan P. Berger, Jan S. F. Sanders, Judy Lieberman, Li Li, Jamil R. Azzi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Regulatory T cells (Tregs) have shown great promise as a means of cellular therapy in a multitude of allo- and auto-immune diseases—due in part to their immunosuppressive potency. Nevertheless, the clinical efficacy of human Tregs in patients has b
Externí odkaz:
https://doaj.org/article/bf198d45ad224883b3b5ae64e9a8c7c8
Autor:
Songjie Cai, John Y. Choi, Thiago J. Borges, Hengcheng Zhang, Ji Miao, Takaharu Ichimura, Xiaofei Li, Simiao Xu, Philip Chu, Siawosh K. Eskandari, Hazim Allos, Juliano B. Alhaddad, Saif A. Muhsin, Karim Yatim, Leonardo V. Riella, Peter T. Sage, Anil K. Chandraker, Jamil R. Azzi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Solid organ transplantation is a lifesaving therapy for patients with end-organ disease. Current immunosuppression protocols are not designed to target antigen-specific alloimmunity and are uncapable of preventing chronic allograft injury. A
Externí odkaz:
https://doaj.org/article/de36c318422d4c6c994a080dce4925be
Autor:
James Hurley, Johan Skog, Anand Srivastava, Albana B Mihali, Leonardo V. Riella, Karim M. Yatim, Jamil Azzi, Mauricio P. Lima Filho, Bruno T. Aoyama, Juliano B. Alhaddad, Siawosh K. Eskandari, Hazim Allos, James F. Markmann, Kassem Safa, Isadora T. Lape, Vasisht Tadigotla, Anil Chandraker, John Choi, Christine M. Coticchia, Richard N. Formica, Areej Alghamdi, Philip Chu, Rania El Fekih
Publikováno v:
J Am Soc Nephrol
Background Developing a noninvasive clinical test to accurately diagnose kidney allograft rejection is critical to improve allograft outcomes. Urinary exosomes, tiny vesicles released into the urine that carry parent cells' proteins and nucleic acids
Publikováno v:
Current Transplantation Reports. 7:291-300
Soon after their discovery in 1972, regulatory T cells (Tregs) appeared as nature’s gift to induce tolerance in auto- and alloimmune settings. We review here the barriers to the use of these bona fide cells and the strategies implanted to overcome
Autor:
Amr Mansouri, Siawosh K. Eskandari, Harvey Cantor, John Choi, Jamil Azzi, Melissa Y. Yeung, Eman Alhussain, Saif A. Muhsin, Songjie Cai, Hye-Jung Kim, Hazim Allos, Jean Pierre Assaker, Marc A. Seelen, Ina Sulkaj, Juliano B. Alhaddad
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 117(11), 6042-6046. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America, 117(11), 6042-6046. NATL ACAD SCIENCES
Induction of longstanding immunologic tolerance is essential for survival of transplanted organs and tissues. Despite recent advances in immunosuppression protocols, allograft damage inflicted by antibody specific for donor organs continues to repres
Autor:
Leonardo V. Riella, Peter T. Sage, Juliano B. Alhaddad, Simiao Xu, Hazim Allos, Anil Chandraker, Saif A. Muhsin, Thiago J. Borges, Xiaofei Li, Philip Chu, Songjie Cai, Hengcheng Zhang, John Choi, Jamil Azzi, Ji Miao, Takaharu Ichimura, Siawosh K. Eskandari, Karim M. Yatim
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Solid organ transplantation is a lifesaving therapy for patients with end-organ disease. Current immunosuppression protocols are not designed to target antigen-specific alloimmunity and are uncapable of preventing chronic allograft injury. As myeloid
Publikováno v:
Clinics in laboratory medicine. 39(1)
There has been a prolific amount of research dedicated to the T-regulatory cells (Tregs) and their role in achieving immune homeostasis. Here, the authors briefly discuss the known biology, utilization, and potential of Tregs, for current trials and
Autor:
Yousef Haik, Henri G. D. Leuvenink, Juliano B. Alhaddad, Li Tang, Marc A. Seelen, Songjie Cai, Ina Sulkaj, Bakhos A. Tannous, John Choi, Na Li, Darrell J. Irvine, Jamil Azzi, Arach S. Eskandari, Jean Pierre Assaker, Siawosh K. Eskandari, Amr Mansouri, Leonardo V. Riella, Hazim Allos, Mariane B. Melo, Max Zinter, Willem J. van Son, Branislav Kollar, Thiago J Borges, Bohdan Pomahac, Basmah S. Al Dulaijan
Publikováno v:
Science Translational Medicine, 12(569):4744, 1-16. AMER ASSOC ADVANCEMENT SCIENCE
Adoptive cell transfer of ex vivo expanded regulatory T cells (T-r(egs)) has shown immense potential in animal models of auto- and alloimmunity. However, the effective translation of such T-reg therapies to the clinic has been slow. Because T-reg hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b533ccd15beae2291f33c01c12057052
https://infoscience.epfl.ch/record/282085
https://infoscience.epfl.ch/record/282085