Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hazem Safory"'
Autor:
Fatimah Abd Elghani, Hazem Safory, Haya Hamza, Mor Savyon, Malik Farhoud, Michal Toren‐Hershoviz, Zagorka Vitic, Kirsten Ebanks, Vered Shani, Sleman Bisharat, Lihi Shaulov, Claude Brodski, Zhiyin Song, Rina Bandopadhyay, Simone Engelender
Publikováno v:
Aging cell. 21(12)
Parkinson's disease (PD) is characterized by degeneration of neurons, particularly dopaminergic neurons in the substantia nigra. PD brains show accumulation of α-synuclein in Lewy bodies and accumulation of dysfunctional mitochondria. However, the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edaec35675c39c755c0247be306df768
https://pubmed.ncbi.nlm.nih.gov/36307912
https://pubmed.ncbi.nlm.nih.gov/36307912
Autor:
Marialaura Marchetti, Hazem Safory, Shai Kellner, Simone Engelender, Shai Berlin, Inna Radzishevsky, Veronika N. Foltyn, Samah Neame, Francesco Marchesani, Ayelet Touitou, Jean-Marie Billard, Herman Wolosker
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (41), pp.20736-20742. ⟨10.1073/pnas.1909458116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (41), pp.20736-20742. ⟨10.1073/pnas.1909458116⟩
Astrocytes express the 3-phosphoglycerate dehydrogenase (Phgdh) enzyme required for the synthesis of l-serine from glucose. Astrocytic l-serine was proposed to regulate NMDAR activity by shuttling to neurons to sustain d-serine production, but this h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907772d4c795daf274edd8133a3fc20f
https://doi.org/10.1073/pnas.1909458116
https://doi.org/10.1073/pnas.1909458116
Autor:
Sharon S Lander, Amit Gross, Inna Gaisler-Salomon, Herman Wolosker, Sergiy Chornyy, Hazem Safory
Publikováno v:
Genes, brain, and behaviorREFERENCES. 19(6)
Glutamate Dehydrogenase 1 (GDH), encoded by the Glud1 gene in rodents, is a mitochondrial enzyme critical for maintaining glutamate homeostasis at the tripartite synapse. Our previous studies indicate that the hippocampus may be particularly vulnerab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1b65fee6d1f29483b93765fd9a0554
https://pubmed.ncbi.nlm.nih.gov/31898404
https://pubmed.ncbi.nlm.nih.gov/31898404
Autor:
Mor Savyon, Fatimah Abd Elghani, Ruth Rott, Kah-Leong Lim, Tsipora Cohen, Rina Bandopadhyay, Ninghan Wang, Raymonde Szargel, Simone Engelender, Vered Shani, Lihi Shaulov, Christopher A. Ross, Hazem Safory, Hui Zhang, Inna Radzishevsky, Haya Hamza
Publikováno v:
Hum Mol Genet
Mutations in LRRK2 cause autosomal dominant and sporadic Parkinson’s disease, but the mechanisms involved in LRRK2 toxicity in PD are yet to be fully understood. We found that LRRK2 translocates to the nucleus by binding to seven in absentia homolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65005dcf0714e9df0168b83894528018
https://pubmed.ncbi.nlm.nih.gov/31626293
https://pubmed.ncbi.nlm.nih.gov/31626293
Autor:
Hanoch Kaphzan, Sharon S Lander, Inna Gaisler-Salomon, Darpan Chakraborty, Herman Wolosker, Kfir Asraf, Hazem Safory
BACKGROUND: Glutamatergic abnormalities are commonly observed in schizophrenia (SZ) and are hypothesized to play an important role in cognitive dysfunction. While the contribution of postsynaptic glutamate receptors to SZ psychopathology has been ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a52c903e6b5172df8de0d822399c471
https://europepmc.org/articles/PMC6455389/
https://europepmc.org/articles/PMC6455389/
Autor:
Elena Dumin, Hazem Safory, Dina Rosenberg, Herman Wolosker, Hisashi Mori, Inna Radzishevsky, Goren Kolodney
Publikováno v:
Journal of Biological Chemistry. 290:31037-31050
D-Serine is a physiological co-agonist that activates N-methyl D-aspartate receptors (NMDARs) and is essential for neurotransmission, synaptic plasticity, and behavior. D-Serine may also trigger NMDAR-mediated neurotoxicity, and its dysregulation may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dd67ce9d6c0a6b75ff37df4edc89ef2
https://doi.org/10.1074/jbc.m115.699496
https://doi.org/10.1074/jbc.m115.699496
Autor:
Ran Taube, Daniel Gitler, Yael Sarusi, Vukasin M. Jovanovic, Joy Kahn, Claude Brodski, Hazem Safory, Zagorka Vitic, Simone Engelender, Alexandra Stavsky, Lilah Toker, Roland H. Friedel, Alona Kuzmina
Publikováno v:
Brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668e90fa6065dddae29a2292af4a3b0d
http://europepmc.org/articles/PMC7940172
http://europepmc.org/articles/PMC7940172
Asc-1 transporter regulation of synaptic activity via the tonic release of D-serine in the forebrain
Autor:
Hazem Safory, Eitan Kaplan, Jean-Marie Billard, Christoffer Bundgaard, Christian Thomsen, Avi Avital, Hagit Sason, Salman Zubedat, Samah Neame, Kenneth Vielsted Christensen, Dina Rosenberg, Claus Tornby Christoffersen, Garrick Paul Smith, Herman Wolosker, Veronika N. Foltyn
Publikováno v:
Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2017, 27 (2), pp.1573-1587. ⟨10.1093/cercor/bhv350⟩
Cerebral Cortex, Oxford University Press (OUP), 2017, 27, pp.1573-1587. ⟨10.1177/0271678X15626718⟩
Cerebral Cortex, Oxford University Press (OUP), 2017, 27 (2), pp.1573-1587. ⟨10.1093/cercor/bhv350⟩
Cerebral Cortex, Oxford University Press (OUP), 2017, 27, pp.1573-1587. ⟨10.1177/0271678X15626718⟩
d-Serine is a co-agonist of NMDA receptors (NMDARs) whose activity is potentially regulated by Asc-1 (SLC7A10), a transporter that displays high affinity for d-serine and glycine. Asc-1 operates as a facilitative transporter and as an antiporter, tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e811a43353d2e0dd0cbd67c9faf985c
https://hal-normandie-univ.archives-ouvertes.fr/hal-02325027
https://hal-normandie-univ.archives-ouvertes.fr/hal-02325027
Autor:
Goren, Kolodney, Elena, Dumin, Hazem, Safory, Dina, Rosenberg, Hisashi, Mori, Inna, Radzishevsky, Inna, Radzishevisky, Herman, Wolosker
Publikováno v:
The Journal of biological chemistry. 290(52)
d-Serine is a physiological co-agonist that activates N-methyl d-aspartate receptors (NMDARs) and is essential for neurotransmission, synaptic plasticity, and behavior. d-Serine may also trigger NMDAR-mediated neurotoxicity, and its dysregulation may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581ea827ddff2259fcaa1864369badda
https://pubmed.ncbi.nlm.nih.gov/26851299
https://pubmed.ncbi.nlm.nih.gov/26851299
Autor:
Yoav Shulman, Herman Wolosker, Dina Rosenberg, Samah Neame, Salman Zubedat, Simone Engelender, Hazem Safory, Jackie Schiller, Avi Avital, Swen Hülsmann, Inna Radzishevsky, Hagit Sason
Publikováno v:
EMBO reports. 16(5)
Asc-1 (SLC7A10) is an amino acid transporter whose deletion causes neurological abnormalities and early postnatal death in mice. Using metabolomics and behavioral and electrophysiological methods, we demonstrate that Asc-1 knockout mice display a mar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5a67c33a53f3440a42bed2755505a1
https://pubmed.ncbi.nlm.nih.gov/25755256
https://pubmed.ncbi.nlm.nih.gov/25755256