Výsledky vyhledávání - "Hazel Y. Stevens"

Akademický článek

Intra-articular delivery of micronized dehydrated human amnion/chorion membrane reduces degenerative changes after onset of post-traumatic osteoarthritis

Autor: Angela S. P. Lin, David S. Reece, Tanushree Thote, Sanjay Sridaran, Hazel Y. Stevens, Nick J. Willett, Robert E. Guldberg

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)

Background: Micronized dehydrated human amnion/chorion membrane (mdHACM) has reduced short term post-traumatic osteoarthritis (PTOA) progression in rats when delivered 24 h after medial meniscal transection (MMT) and is being investigated for clinica

Externí odkaz: https://doaj.org/article/68fa819005114570b22b49814442e2c5

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Akademický článek

Mesenchymal stromal cells for bone trauma, defects, and disease: Considerations for manufacturing, clinical translation, and effective treatments

Autor: Annie C. Bowles-Welch, Angela C. Jimenez, Hazel Y. Stevens, David A. Frey Rubio, Linda E. Kippner, Carolyn Yeago, Krishnendu Roy

Publikováno v: Bone Reports, Vol 18, Iss , Pp 101656- (2023)

Bone is a complex tissue capable of natural repair to injury, however, the healing process is often impaired by the untoward effects of trauma, defects, and disease. Thus, therapeutic modalities, including the use of cells involved in the body's natu

Externí odkaz: https://doaj.org/article/f9a8f6c1ab4e4176b2ba850e5238c3c2

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Akademický článek

Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations

Autor: Camila Medrano-Trochez, Paramita Chatterjee, Pallab Pradhan, Hazel Y. Stevens, Molly E. Ogle, Edward A. Botchwey, Joanne Kurtzberg, Carolyn Yeago, Greg Gibson, Krishnendu Roy

Publikováno v: Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)

Abstract Background Human Mesenchymal stromal cells (hMSCs) from various tissue sources are widely investigated in clinical trials. These MSCs are often administered to patients immediately after thawing the cryopreserved product (out-of-thaw), yet l

Externí odkaz: https://doaj.org/article/6fea1886cd2e42f6a0a90995bb79307f

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Akademický článek

Molecular Crosstalk Between Macrophages and Mesenchymal Stromal Cells

Autor: Hazel Y. Stevens, Annie C. Bowles, Carolyn Yeago, Krishnendu Roy

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Mesenchymal stromal cells (MSCs) have been widely investigated for regenerative medicine applications, from treating various inflammatory diseases as a cell therapy to generating engineered tissue constructs. Numerous studies have evaluated the poten

Externí odkaz: https://doaj.org/article/67bc1f101a224a8ea5f150efaed3566c

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Patient-Specific iPSC-Derived Models Link Aberrant Endoplasmic Reticulum Stress Sensing and Response to Juvenile Osteochondritis Dissecans Etiology

Autor: Giuliana E Salazar-Noratto, Catriana C Nations, Hazel Y Stevens, Maojia Xu, Sean Gaynard, Claire Dooley, Nica de Nijs, Katya McDonagh, Sanbing Shen, S Clifton Willimon, Frank Barry, Robert E Guldberg

Publikováno v: Stem Cells Translational Medicine. 12:293-306

Juvenile osteochondritis dissecans (JOCD) is a pediatric disease, which begins with an osteonecrotic lesion in the secondary ossification center which, over time, results in the separation of the necrotic fragment from the parent bone. JOCD predispos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8365db9ebe5b5b06fb22730de100d804
https://doi.org/10.1093/stcltm/szad018

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Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations

Autor: Paramita Chatterjee, Joanne Kurtzberg, Krishnendu Roy, Hazel Y. Stevens, Molly E Ogle, Carolyn Yeago, Edward A. Botchwey, Pallab Pradhan, Camila Medrano-Trochez, Greg Gibson

Publikováno v: Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)
Stem Cell Research & Therapy

Background Human Mesenchymal stromal cells (hMSCs) from various tissue sources are widely investigated in clinical trials. These MSCs are often administered to patients immediately after thawing the cryopreserved product (out-of-thaw), yet little is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281be43d68638348d1d1257eaeda7374
https://doi.org/10.1186/s13287-021-02627-9

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Regional gene expression analysis of multiple tissues in an experimental animal model of post-traumatic osteoarthritis

Autor: Robert E. Guldberg, Hazel Y. Stevens, N. De Nijs, Greg Gibson, Giuliana E. Salazar-Noratto

Publikováno v: Osteoarthritis and Cartilage. 27:294-303

Summary Objective To characterize local disease progression of the medial meniscus transection (MMT) model of post-traumatic osteoarthritis (OA) at the molecular level, in order to establish a baseline for therapeutic testing at the preclinical stage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8657d3783e1831eee0d0a8fc600ef971
https://doi.org/10.1016/j.joca.2018.10.007

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Chondroitin Sulfate Glycosaminoglycan Scaffolds for Cell and Recombinant Protein‐Based Bone Regeneration

Autor: Lohitash Karumbaiah, Hazel Y. Stevens, Erin T. Jordan, Meghan T. Logun, Robert E. Guldberg, Albert Cheng, Boao Xia, Seth H. Andrews, Robin L. Webb, Steven L. Stice

Publikováno v: Stem Cells Translational Medicine
Stem Cells Translational Medicine, Vol 8, Iss 6, Pp 575-585 (2019)

Bone morphogenetic protein 2 (BMP-2)-loaded collagen sponges remain the clinical standard for treatment of large bone defects when there is insufficient autograft, despite associated complications. Recent efforts to negate comorbidities have included

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1394cffcf10c0c73c40156dd002471
http://europepmc.org/articles/PMC6525555

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