Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Hazel Tye"'
Autor:
Hazel Tye, Chien-Hsiung Yu, Lisa A. Simms, Marcel R. de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S. Penington, Cassandra R. Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F. Wockner, Adele Preaudet, Lisa A. Mielke, Stephen A. Wilcox, Yasunori Ogura, Sinead C. Corr, Komal Kanojia, Konstantinos A. Kouremenos, David P. De Souza, Malcolm J. McConville, Richard A. Flavell, Motti Gerlic, Benjamin T. Kile, Anthony T. Papenfuss, Tracy L. Putoczki, Graham L. Radford-Smith, Seth L. Masters
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The inflammasome is normally activated by pathogens to induce tissue inflammation. Here the authors show that, in mouse experimental colitis models, Nlrp1 inflammasome sensor activates IL-18 to reduce beneficial colonic Clostridiales species, thereby
Externí odkaz:
https://doaj.org/article/289da6d10257442191a1c6fe56d983a8
Publikováno v:
Biomolecules, Vol 11, Iss 5, p 646 (2021)
Chronic inflammatory disorders are characterised by aberrant and exaggerated inflammatory immune cell responses. Modes of extrinsic cell death, apoptosis and necroptosis, have now been shown to be potent drivers of deleterious inflammation, and mutat
Externí odkaz:
https://doaj.org/article/35afe3e239d442079e0f40b3302f3ac8
Autor:
Brendan J. Jenkins, Tracy Putoczki, Cem Gabay, Masanobu Oshima, Matthias Ernst, Meri Najdovska, Hazel Tye, Ka Yee Fung, Hiroko Oshima, Adele Preaudet, Charlotte Girard, Thaleia Livis, Jesse Balic, Saleela M. Ruwanpura, Liang Yu, Alison F. Browning, Alison West, Paul Nguyen, Virginie Deswaerte
The content of this file containing Supplementary Figures (and a Supplementary Table) provides additional (and essential) data supporting our conclusions that the ASC inflammasome/caspase-1/IL-18 axis promotes gastric tumorigenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f645c44a30e642b4a7137f788bfaeca
https://doi.org/10.1158/0008-5472.22412141.v1
https://doi.org/10.1158/0008-5472.22412141.v1
Autor:
Brendan J. Jenkins, Tracy Putoczki, Cem Gabay, Masanobu Oshima, Matthias Ernst, Meri Najdovska, Hazel Tye, Ka Yee Fung, Hiroko Oshima, Adele Preaudet, Charlotte Girard, Thaleia Livis, Jesse Balic, Saleela M. Ruwanpura, Liang Yu, Alison F. Browning, Alison West, Paul Nguyen, Virginie Deswaerte
Inflammasomes are key regulators of innate immunity in chronic inflammatory disorders and autoimmune diseases, but their role in inflammation-associated tumorigenesis remains ill-defined. Here we reveal a protumorigenic role in gastric cancer for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::801933ca152887dfe221ae1ba60ea2a9
https://doi.org/10.1158/0008-5472.c.6508370.v1
https://doi.org/10.1158/0008-5472.c.6508370.v1
Autor:
Hazel Tye, Stephanie A. Conos, Tirta M. Djajawi, Nasteho Abdoulkader, Isabella Y. Kong, Helene L. Kammoun, Vinod K. Narayana, Mary Speir, Timothy A. Gottschalk, Jack Emery, Daniel S. Simpson, Cathrine Hall, Angelina J. Vince, Sophia Russo, Rhiannan Crawley, Maryam Rashidi, Joanne M. Hildebrand, James M. Murphy, Lachlan Whitehead, David P. De Souza, Seth L. Masters, Edwin D. Hawkins, Andrew J. Murphy, James E. Vince, Kate E. Lawlor
Cell death frequently occurs in the pathogenesis of obesity and non-alcoholic fatty liver disease (NAFLD). However, the exact contribution of core cell death machinery to disease manifestations remains ill-defined. Here, we showviathe direct comparis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15e6a1f9b0da98a3b47b265262051bbd
https://doi.org/10.1101/2023.03.14.532682
https://doi.org/10.1101/2023.03.14.532682
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 646, p 646 (2021)
Biomolecules, Vol 11, Iss 646, p 646 (2021)
Chronic inflammatory disorders are characterised by aberrant and exaggerated inflammatory immune cell responses. Modes of extrinsic cell death, apoptosis and necroptosis, have now been shown to be potent drivers of deleterious inflammation, and mutat
Autor:
Daniel S. Simpson, Jiyi Pang, Ashley Weir, Isabella Y. Kong, Melanie Fritsch, Maryam Rashidi, James P. Cooney, Kathryn C. Davidson, Mary Speir, Tirta M. Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A. Conos, Hazel Tye, Seong H. Chow, Arfatur Rahman, Raymond S. Norton, Thomas Naderer, Sandra E. Nicholson, Gaetan Burgio, Si Ming Man, Joanna R. Groom, Marco J. Herold, Edwin D. Hawkins, Kate E. Lawlor, Andreas Strasser, John Silke, Marc Pellegrini, Hamid Kashkar, Rebecca Feltham, James E. Vince
Publikováno v:
Immunity. 55:423-441.e9
Cell death plays an important role during pathogen infections. Here, we report that interferon-γ (IFNγ) sensitizes macrophages to Toll-like receptor (TLR)-induced death that requires macrophage-intrinsic death ligands and caspase-8 enzymatic activi
Autor:
Malcolm J. McConville, Fernando Souza-Fonseca-Guimaraes, Motti Gerlic, Komal Kanojia, Adele Preaudet, Benjamin T. Kile, Marcel R. de Zoete, Man Lyang Kim, Konstantinos A. Kouremenos, Yasunori Ogura, Richard A. Flavell, David P De Souza, Cassandra R. Harapas, Tracy L Putoczki, Stephen Wilcox, Hazel Tye, Seth L. Masters, Graham L. Radford-Smith, Sinéad C. Corr, Martha Zakrzewski, Jocelyn Sietsma Penington, Leesa F. Wockner, Chien-Hsiung Yu, Anthony T. Papenfuss, Lisa A. Simms, Lisa A. Mielke
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, 9(1). Nature Publishing Group
Nature Communications, 9(1). Nature Publishing Group
Anti-microbial signaling pathways are normally triggered by innate immune receptors when detecting pathogenic microbes to provide protective immunity. Here we show that the inflammasome sensor Nlrp1 aggravates DSS-induced experimental mouse colitis b
Autor:
Dena Lyras, Hyun-Ja Ko, Ben A. Croker, Andrew W. Roberts, Seth L. Masters, Ladina DiRago, Hazel Tye, Benjamin T. Kile, Daniel L. Kastner, Louise H. Cengia, Andrew M. Lew, Dominic De Nardo, Donald Metcalf, Yong Hwan Park, Jae Jin Chae, Man Lyang Kim, Roslynn A. Stirzaker
Publikováno v:
The Journal of Experimental Medicine
Kim et al. identify an autoinflammatory disease in mice that is driven by IL-18, resulting from an inactivating mutation in the actin-depolymerizing cofactor Wdr1. This alteration in actin dynamics is recognized by the pyrin inflammasome and results
Autor:
Liang Yu, Adele Preaudet, Hazel Tye, Virginie Deswaerte, Masanobu Oshima, Hiroko Oshima, Jesse J. Balic, Alison C. West, Alison F. Browning, Matthias Ernst, Brendan J. Jenkins, Thaleia Livis, Saleela Ruwanpura, Paul M Nguyen, Meri Najdovska, Ka Yee Fung, Charlotte Girard, Tracy L Putoczki, Cem Gabay
Publikováno v:
Cancer Research, Vol. 78, No 5 (2018) pp. 1293-1307
Inflammasomes are key regulators of innate immunity in chronic inflammatory disorders and autoimmune diseases, but their role in inflammation-associated tumorigenesis remains ill-defined. Here we reveal a protumorigenic role in gastric cancer for the