Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Hazel Stewart"'
Autor:
Charlotte Lefèvre, Georgia M. Cook, Adam M. Dinan, Shiho Torii, Hazel Stewart, George Gibbons, Alex S. Nicholson, Liliana Echavarría-Consuegra, Luke W. Meredith, Valeria Lulla, Naomi McGovern, Julia C. Kenyon, Ian Goodfellow, Janet E. Deane, Stephen C. Graham, András Lakatos, Louis Lambrechts, Ian Brierley, Nerea Irigoyen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Zika virus (ZIKV), an emerging mosquito-borne flavivirus, is associated with congenital neurological complications. Here, we investigate potential pathological correlates of virus gene expression in representative ZIKV strains through RNA se
Externí odkaz:
https://doaj.org/article/2dc4a2034fc449a8bca35da7cbd3b0c0
Autor:
Hazel Stewart, Yongxu Lu, Sarah O’Keefe, Anusha Valpadashi, Luis Daniel Cruz-Zaragoza, Hendrik A. Michel, Samantha K. Nguyen, George W. Carnell, Nina Lukhovitskaya, Rachel Milligan, Yasmin Adewusi, Irwin Jungreis, Valeria Lulla, David A. Matthews, Stephen High, Peter Rehling, Edward Emmott, Jonathan L. Heeney, Andrew D. Davidson, James R. Edgar, Geoffrey L. Smith, Andrew E. Firth
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108080- (2023)
Summary: The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative genomic approaches, an additional accessory protein, ORF3c, has been predicted to be encoded within the ORF3a sgmRNA. Expression of ORF3c during infection has
Externí odkaz:
https://doaj.org/article/0eb2381740c24412b7c9b4e912187e2a
Autor:
Matthew D. Parker, Hazel Stewart, Ola M. Shehata, Benjamin B. Lindsey, Dhruv R. Shah, Sharon Hsu, Alexander J. Keeley, David G. Partridge, Shay Leary, Alison Cope, Amy State, Katie Johnson, Nasar Ali, Rasha Raghei, Joe Heffer, Nikki Smith, Peijun Zhang, Marta Gallis, Stavroula F. Louka, Hailey R. Hornsby, Hatoon Alamri, Max Whiteley, Benjamin H. Foulkes, Stella Christou, Paige Wolverson, Manoj Pohare, Samantha E. Hansford, Luke R. Green, Cariad Evans, Mohammad Raza, Dennis Wang, Andrew E. Firth, James R. Edgar, Silvana Gaudieri, Simon Mallal, The COVID-19 Genomics UK (COG-UK) consortium, Mark O. Collins, Andrew A. Peden, Thushan I. de Silva
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Matthew Parker et al. use the ARTIC network tiled amplicon PCR and Oxford Nanopore sequencing of thousands of SARS-CoV-2 samples to detect subgenomic RNA changes in the B.1.1.7 lineage endemic in the UK in late 2020/early 2021. They discovered higher
Externí odkaz:
https://doaj.org/article/a4136fc5fe3f462ca4c6714d58abfce9
Autor:
Layla Mathieson, Richard A. O’Connor, Hazel Stewart, Paige Shaw, Kevin Dhaliwal, Gareth O. S. Williams, Alicia Megia-Fernandez, Ahsan R. Akram
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Fibroblast activation protein (FAP) is a cell surface propyl-specific serine protease involved in the regulation of extracellular matrix. Whilst expressed at low levels in healthy tissue, upregulation of FAP on fibroblasts can be found in several sol
Externí odkaz:
https://doaj.org/article/8480606777e94e29b23b0e514a2ea885
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006834 (2018)
The NS5A protein of hepatitis C virus (HCV) plays roles in both virus genome replication and assembly. NS5A comprises three domains, of these domain I is believed to be involved exclusively in genome replication. In contrast, domains II and III are r
Externí odkaz:
https://doaj.org/article/f898616296b443769a0bf45fc297411d
Autor:
Yousuf A. Khan, Gary Loughran, Anna-Lena Steckelberg, Katherine Brown, Stephen J. Kiniry, Hazel Stewart, Pavel V. Baranov, Jeffrey S. Kieft, Andrew E. Firth, John F. Atkins
Publikováno v:
Nature
Autor:
Hazel Stewart, Yongxu Lu, Sarah O’Keefe, Anusha Valpadashi, Luis Daniel Cruz-Zaragoza, Hendrik A. Michel, Samantha K. Nguyen, George W. Carnell, Nina Lukhovitskaya, Rachel Milligan, Irwin Jungreis, Valeria Lulla, Andrew D. Davidson, David A. Matthews, Stephen High, Peter Rehling, Edward Emmott, Jonathan L. Heeney, James R. Edgar, Geoffrey L. Smith, Andrew E. Firth
SUMMARYThe SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative genomic approaches, an additional accessory protein, ORF3c, has been predicted to be encoded within the ORF3a sgmRNA. Expression of ORF3c during infection has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3fd948771f7b0e16697a17c70740811
https://doi.org/10.1101/2022.11.15.516323
https://doi.org/10.1101/2022.11.15.516323
Autor:
Katharina M. Scherer, Luca Mascheroni, George W. Carnell, Lucia C. S. Wunderlich, Stanislaw Makarchuk, Marius Brockhoff, Ioanna Mela, Ana Fernandez-Villegas, Max Barysevich, Hazel Stewart, Maria Suau Sans, Charlotte L. George, Jacob R. Lamb, Gabriele S. Kaminski-Schierle, Jonathan L. Heeney, Clemens F. Kaminski
Despite being the target of extensive research efforts due to the COVID-19 (coronavirus disease 2019) pandemic, relatively little is known about the dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication within cells. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cee3a6a1f486de24a79e2cfe610a726
https://www.repository.cam.ac.uk/handle/1810/332628
https://www.repository.cam.ac.uk/handle/1810/332628
Autor:
Roseanne Rosario, Richard A. Anderson, Nicolas Charlet-Berguerand, Gracjan Michlewski, Nila Roy Choudhury, Hazel Stewart
Fragile X-associated premature ovarian insufficiency (FXPOI) is caused by expansion of a CGG repeat sequence located in the 5’ untranslated region of the FMR1 gene. Women with FXPOI have a depleted ovarian reserve, resulting in amenorrhea, hypoestr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db926a3c0348a0a7993b95f58ef0e8b0
https://doi.org/10.21203/rs.3.rs-904337/v1
https://doi.org/10.21203/rs.3.rs-904337/v1
Autor:
Matthew D, Parker, Hazel, Stewart, Ola M, Shehata, Benjamin B, Lindsey, Dhruv R, Shah, Sharon, Hsu, Alexander J, Keeley, David G, Partridge, Shay, Leary, Alison, Cope, Amy, State, Katie, Johnson, Nasar, Ali, Rasha, Raghei, Joe, Heffer, Nikki, Smith, Peijun, Zhang, Marta, Gallis, Stavroula F, Louka, Hailey R, Hornsby, Hatoon, Alamri, Max, Whiteley, Benjamin H, Foulkes, Stella, Christou, Paige, Wolverson, Manoj, Pohare, Samantha E, Hansford, Luke R, Green, Cariad, Evans, Mohammad, Raza, Dennis, Wang, Andrew E, Firth, James R, Edgar, Silvana, Gaudieri, Simon, Mallal, Mark O, Collins, Andrew A, Peden, Thushan I, de Silva
Publikováno v:
Communications biology. 5(1)
B.1.1.7 lineage SARS-CoV-2 is more transmissible, leads to greater clinical severity, and results in modest reductions in antibody neutralization. Subgenomic RNA (sgRNA) is produced by discontinuous transcription of the SARS-CoV-2 genome. Applying ou