Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Hazel M. Robinson"'
Autor:
Nick Telford, Nicole Dastugue, Michael R. Stratton, Paul Sinclair, Yang Li, Peter Vandenberghe, Richard J. Q. McNally, Fiona M. Ross, Patricia Jacobs, Nyla A. Heerema, Christine J. Harrison, Julian Borrow, Peter Van Loo, Olivia Joseph, Vikki Rand, Polly Talley, Philip J. Stephens, Bryan D. Young, Claire Schwab, Nick Bown, Mark Maddison, Andrew J. Carroll, Hazel M. Robinson, Anthony V. Moorman, Claudia Haferlach, Elli Papaemmanuil, Mike Griffiths, Peter J. Campbell, Lorraine Gaunt, Ben Robinson, Sarra Ryan, Sara Dyer, Manuel R. Teixeira, Jiqiu Cheng
Publikováno v:
Nature
Changes in gene dosage are a major driver of cancer, known to be caused by a finite, but increasingly well annotated, repertoire of mutational mechanisms1. This can potentially generate correlated copy-number alterations across hundreds of linked gen
Autor:
Ajay Vora, Jeremy Hancock, Hazel M. Robinson, Christine J. Harrison, Sue Richards, Chris Mitchell, Anthony V. Moorman, Nicholas Goulden, Claire Schwab
Publikováno v:
Scopus-Elsevier
Purpose To evaluate the effect on outcome of intensifying therapy for patients with acute lymphoblastic leukemia (ALL) and an intrachromosomal amplification of chromosome 21 (iAMP21). Patients and Methods We report two cohorts of patients treated on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bea023ec364635c51990742015d209
https://ora.ox.ac.uk/objects/uuid:f9935d21-1c49-439b-a296-e9f1d5fc5598
https://ora.ox.ac.uk/objects/uuid:f9935d21-1c49-439b-a296-e9f1d5fc5598
Autor:
Louise Harewood, G R Jalali, Christine J. Harrison, Rachel L. Harris, Chris Mitchell, Anthony V. Moorman, N. Sumption, Hazel M. Robinson, M Martineau, Susan M. Richards, M. S. Jabbar Al-Obaidi
This study identifies multiple copies of the AML1 gene on a duplicated chromosome 21, dup(21), as a recurrent abnormality in acute lymphoblastic leukemia (ALL). Clusters of AML1 signals were visible at interphase by fluorescence in situ hybridization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c1397503a146d74c4936fef16a647e
https://doi.org/10.1038/sj.leu.2402849
https://doi.org/10.1038/sj.leu.2402849
Autor:
Sharron Glide, Sarah Mould, Jonathan C. Strefford, Tanja Stankovic, Anne Gardiner, Ian Tracy, Hazel M. Robinson, David Oscier, Helen Parker
Publikováno v:
Leukemia Research. 36:307-310
Deletion of ATM detected by fluorescent in situ hybridization (FISH) in chronic lymphocytic leukemia predicts short treatment free survival and poor outcome following alkylator/purine analogue therapy. We describe five cases, with a diminished ATM FI
Autor:
Julie Irving, Vikki Rand, Jonathan C. Strefford, Sarra Ryan, Hannah M. Ensor, Dino Masic, Helen Parker, Lisa J. Russell, Hazel M. Robinson, Lynne Minto, Paul Sinclair, Anthony V. Moorman, Lisa Jones, Heather Morrison, Claire Schwab, Christine J. Harrison
Publikováno v:
Blood. 117:6848-6855
Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct subgroup of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) that has a dismal outcome when treated with standard therapy. For improved diagnosis and risk st
Autor:
G. Reza Jalali, Christine J. Harrison, Jonathan C. Strefford, Sarah Wright, Rachel L. Harris, Kerry E. Barber, Anthony V. Moorman, Mike Griffiths, Hazel M. Robinson, Zoë J. Broadfield, Louise Harewood, Adam R. M. Stewart, Fiona M. Ross, M Martineau, Kan L. Cheung
Publikováno v:
British Journal of Haematology. 129:520-530
Summary Interphase fluorescence in situ hybridization (iFISH) was used independently to reveal chromosomal abnormalities of prognostic importance in a large, consecutive series of children (n = 2367) with acute lymphoblastic leukaemia (ALL). The fusi
Autor:
G. Reza Jalali, Zoë J. Broadfield, Hazel M. Robinson, M Martineau, Mark McKinley, Zuzana Zemanova, Kyra Michalova, Christine J. Harrison, Richard Hain
Publikováno v:
British Journal of Haematology. 126:307-312
Prenatal acquisition of leukaemia-associated gene rearrangements is a well-established phenomenon. This is the first report of a complex cytogenetic clone, in association with an ETV6/AML1 fusion, developing in utero. Identical twin girls, aged 4 yea
Autor:
Rachel L. Harris, G. Reza Jalali, Frank Hill, Susan M. Richards, I. Jill Durrant, Ajay Vora, Christine J. Harrison, Tim O B Eden, Anthony H. Goldstone, Hazel M. Robinson, Zoë J. Broadfield, Kerry E. Barber, Sally E. Kinsey, M Martineau, Brenda Gibson, Ian Hann, Ian M. Franklin, Kan L. Cheung, Chris Mitchell, Anthony V. Moorman, John S. Lilleyman
Publikováno v:
British Journal of Haematology. 125:552-559
This study of children and adults with acute lymphoblastic leukaemia (ALL) is the largest series of patients with hypodiploidy (
Autor:
M Martineau, Kan Luk Cheung, Brenda Gibson, Christine J. Harrison, Tim O B Eden, Sally E. Kinsey, Zoë J. Broadfield, Rachel L. Harris, G. Reza Jalali, Kerry E. Taylor, Hazel M. Robinson, Ian Hann, Frank Hill, Chris Mitchell, Anthony V. Moorman, Sue Richards
Publikováno v:
Blood. 102:2756-2762
High hyperdiploidy (HeH) (51 to 65 chromosomes) is found in one third of children with acute lymphoblastic leukemia and is associated with a good prognosis. Cytogenetic features may further refine this prognosis and identify patients with a poor outc
Publikováno v:
Cancer genetics and cytogenetics. 181(1)
The cell line ARH77 is derived from a patient with plasma cell leukemia and has a complex and continually evolving karyotype. It is frequently used in biological studies of myeloma and plasma cell leukemia, so accurate characterization of the genome