Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Hazel M, Girvan"'
Autor:
George J. Baker, Hazel M. Girvan, Sarah Matthews, Kirsty J. McLean, Marina Golovanova, Timothy N. Waltham, Stephen E. J. Rigby, David R. Nelson, Richard T. Blankley, Andrew W. Munro
Publikováno v:
ACS Omega, Vol 2, Iss 8, Pp 4705-4724 (2017)
Externí odkaz:
https://doaj.org/article/9d2e711fc5a24b71bb75ed933c0f3c61
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11380, p 11380 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
CYP102A1 (BM3) is a catalytically self-sufficient flavocytochrome fusion protein isolated from Bacillus megaterium, which displays similar metabolic capabilities to many drug-metabolizing human P450 isoforms. BM3′s high catalytic efficiency, ease o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a932e02627b452e920a3d0974679ff87
https://pubmed.ncbi.nlm.nih.gov/34768811
https://pubmed.ncbi.nlm.nih.gov/34768811
Autor:
Peter Oladimeji, Jing Wu, Jude Chenge, Taosheng Chen, Sergio C. Chai, Lei Yang, Andrew D. Huber, Jingheng Wang, William C. Wright, Hazel M. Girvan, Andrew W. Munro
Publikováno v:
J Med Chem
The human cytochrome P450 (CYP) enzymes CYP3A4 and CYP3A5 metabolize most drugs and have high similarities in their structure and substrate preference. Whereas CYP3A4 is predominantly expressed in the liver, CYP3A5 is upregulated in cancer, contribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26a1df8e3762917219daa8e8b70f309
https://pubmed.ncbi.nlm.nih.gov/31965799
https://pubmed.ncbi.nlm.nih.gov/31965799
Autor:
Laura N. Jeffreys, Michael W. Voice, Hazel M. Girvan, Linus O. Johannissen, Andrew W. Munro, Kamila J. Pacholarz, Perdita E. Barran
Publikováno v:
Jeffreys, L N, Pacholarz, K J, Johannissen, L O, Girvan, H M, Barran, P E, Voice, M W & Munro, A W 2020, ' Characterization of the structure and interactions of P450 BM3 using hybrid mass spectrometry approaches ', Journal of Biological Chemistry, vol. 295, no. 22, pp. 7595-7607 . https://doi.org/10.1074/jbc.RA119.011630
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The cytochrome P450 monooxygenase P450 BM3 (BM3) is a biotechnologically important and versatile enzyme capable of producing important compounds such as the medical drugs pravastatin and artemether, and the steroid hormone testosterone. BM3 is a natu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d626cea5e2e902e042bc297397e18aab
https://doi.org/10.1074/jbc.RA119.011630
https://doi.org/10.1074/jbc.RA119.011630
Autor:
Stephen E. J. Rigby, Kang Lan Tee, David Leys, Kirsty J. McLean, James Belcher, Sarah Matthews, Andrew W. Munro, Colin Levy, Richard T. Blankley, David A. Parker, Hazel M. Girvan
Publikováno v:
The Journal of Biological Chemistry
The Jeotgalicoccus sp. peroxygenase cytochrome P450 OleTJE (CYP152L1) is a hydrogen peroxide-driven oxidase that catalyzes oxidative decarboxylation of fatty acids, producing terminal alkenes with applications as fine chemicals and biofuels. Understa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba3cf442f7f263bfef7f829b4a5f5e0
https://doi.org/10.1074/jbc.m116.762336
https://doi.org/10.1074/jbc.m116.762336
Autor:
Harshwardhan Poddar, Andrew W. Munro, Marina Golovanova, Michael W. Voice, David Leys, Hazel M. Girvan, Kirsty J. McLean, Colin Levy, Laura N. Jeffreys
Publikováno v:
Scientific Reports
Jeffreys, L, Poddar, H, Golovanova, M, Levy, C, Girvan, H, Mclean, K, Voice, M W, Leys, D & Munro, A 2019, ' Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs ', Nature Scientific Reports, vol. 9, no. 1, 1577, pp. 1-12 . https://doi.org/10.1038/s41598-018-37330-y
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Jeffreys, L, Poddar, H, Golovanova, M, Levy, C, Girvan, H, Mclean, K, Voice, M W, Leys, D & Munro, A 2019, ' Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs ', Nature Scientific Reports, vol. 9, no. 1, 1577, pp. 1-12 . https://doi.org/10.1038/s41598-018-37330-y
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Flavocytochrome P450 BM3 is a natural fusion protein constructed of cytochrome P450 and NADPH-cytochrome P450 reductase domains. P450 BM3 binds and oxidizes several mid- to long-chain fatty acids, typically hydroxylating these lipids at the ω-1, ω-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2172603ad9b84649e4696d229800fa
http://europepmc.org/articles/PMC6367340
http://europepmc.org/articles/PMC6367340
Autor:
David R. Nelson, Hazel M. Girvan, Kirsty J. McLean, Harshwardhan Poddar, Andrew W. Munro, David Leys, Katherine A. Hollywood, Colin Levy
Publikováno v:
Girvan, H, Poddar, H, Mclean, K, Nelson, D R, Hollywood, K, Levy, C, Leys, D & Munro, A 2018, ' Structural and Catalytic Properties of the Peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus ', Journal of Inorganic Biochemistry, vol. 188 . https://doi.org/10.1016/j.jinorgbio.2018.08.002
Journal of Inorganic Biochemistry
Journal of Inorganic Biochemistry
The CYP152 family of cytochrome P450 enzymes (P450s or CYPs) are bacterial peroxygenases that use hydrogen peroxide to drive hydroxylation and decarboxylation of fatty acid substrates. We have expressed and purified a novel CYP152 family member – C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b764490297daeaa8261fa373a49543d
https://uom.elsevierpure.com/en/publications/8363a3b5-a293-403c-956a-020a55781001
https://uom.elsevierpure.com/en/publications/8363a3b5-a293-403c-956a-020a55781001
Publikováno v:
Methods in enzymology. 608
The cytochrome P450 monooxygenase enzymes (P450s) catalyze a diverse array of chemical transformations, most originating from the insertion of an oxygen atom into a substrate that binds close to the P450 heme. The oxygen is delivered by a highly reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71e520a2b367ca1a3a48c3bb5f83c7f2
https://pubmed.ncbi.nlm.nih.gov/30173763
https://pubmed.ncbi.nlm.nih.gov/30173763
The cytochrome P450 monooxygenase enzymes (P450s) catalyze a diverse array of chemical transformations, most originating from the insertion of an oxygen atom into a substrate that binds close to the P450 heme. The oxygen is delivered by a highly reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::011046c02b9f100070f6aaca39caa769
https://doi.org/10.1016/bs.mie.2018.06.013
https://doi.org/10.1016/bs.mie.2018.06.013
Autor:
Hazel M, Girvan, Justin M, Bradley, Myles R, Cheesman, James R, Kincaid, Yilin, Liu, Kazimierz, Czarnecki, Karl, Fisher, David, Leys, Stephen E J, Rigby, Andrew W, Munro
Publikováno v:
Biochemistry. 55(36)
DGCR8 is the RNA-binding partner of the nuclease Drosha. Their complex (the "Microprocessor") is essential for processing of long, primary microRNAs (pri-miRNAs) in the nucleus. Binding of heme to DGCR8 is essential for pri-miRNA processing. On the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c2c29fe6b7f203dd25c91ae88307a5d
https://pubmed.ncbi.nlm.nih.gov/27546061
https://pubmed.ncbi.nlm.nih.gov/27546061