Zobrazeno 1 - 10
of 314
pro vyhledávání: '"Hazel M, Dockrell"'
Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity
Autor:
Clare Eckold, Cassandra L. R. vanDoorn, Rovina Ruslami, Katharina Ronacher, Anca‐Lelia Riza, Suzanne vanVeen, Ji‐Sook Lee, Vinod Kumar, Sarah Kerry‐Barnard, Stephanus T. Malherbe, Léanie Kleynhans, Kim Stanley, Simone A. Joosten, Julia A Critchley, Philip C. Hill, Reinout vanCrevel, Cisca Wijmenga, Mariëlle C. Haks, Mihai Ioana, Bachti Alisjahbana, Gerhard Walzl, Tom H. M. Ottenhoff, Hazel M. Dockrell, Eleonora Vianello, Jacqueline M. Cliff, the TANDEM Consortium$
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 9, Pp n/a-n/a (2023)
Abstract Background People with diabetes are more likely to develop tuberculosis (TB) and to have poor TB‐treatment outcomes than those without. We previously showed that blood transcriptomes in people with TB‐diabetes (TB‐DM) co‐morbidity ha
Externí odkaz:
https://doaj.org/article/229588c3fbff41bc8ad7133cef9a8c93
Autor:
Cassandra L.R. van Doorn, Clare Eckold, Katharina Ronacher, Rovina Ruslami, Suzanne van Veen, Ji-Sook Lee, Vinod Kumar, Sarah Kerry-Barnard, Stephanus T. Malherbe, Léanie Kleynhans, Kim Stanley, Philip C. Hill, Simone A. Joosten, Reinout van Crevel, Cisca Wijmenga, Julia A. Critchley, Gerhard Walzl, Bachti Alisjahbana, Mariëlle C. Haks, Hazel M. Dockrell, Tom H.M. Ottenhoff, Eleonora Vianello, Jacqueline M. Cliff
Publikováno v:
EBioMedicine, Vol 82, Iss , Pp 104173- (2022)
Summary: Background: Globally, the tuberculosis (TB) treatment success rate is approximately 85%, with treatment failure, relapse and death occurring in a significant proportion of pulmonary TB patients. Treatment success is lower among people with d
Externí odkaz:
https://doaj.org/article/d8a5f598ec4c4e9383b52b8fc1ff3690
Autor:
Ursula Panzner, Katharina Kranzer, Tsitsi Bandason, Kuda Mutasa, Sandra Rukobo, Charles Sandy, Bariki Mtafya, Andrea Rachow, Norbert Heinrich, Michael Hoelscher, Judith Bruchfeld, Olena Ivanova, Nyanda Elias Ntinginya, Doreen Pamba, Laura Olbrich, Issa Sabi, Simeon Mwanyonga, Elmar Saathoff, Willyhelmina Olomi, Junior Mutsvangwa, Hazel M Dockrell, Edson Tawanda Marambire, Denise Banze, Alfred Mfinanga, Theodora D Mbunda, Khosa Celso, Gunilla Kallenius, Claire J Calderwood, Christof Geldmacher, Kathrin Held, Tejaswi Appalarowthu, Friedrich Rieß, Anna Shepherd, Christopher Sundling, Mishelle Mugava, Martha Chipinduro, Lwitiho Sudi, Antelmo Haule, Emmanuel Sichone, Paschal Qwaray, Harrieth Mwambola, Lilian Minja, Peter Edwin, Dogo Ngalison, Stella Luswema, Celina Nhamuave, António Machiana, Carla Madeira, Emelva Manhiça, Nádia Sitoe, Jorge Ribeiro
Publikováno v:
BMJ Open, Vol 12, Iss 7 (2022)
Introduction The WHO End-TB Strategy calls for the development of novel diagnostics to detect tuberculosis (TB) earlier and more accurately. Better diagnostics, together with tools to predict disease progression, are critical for achieving WHO End-TB
Externí odkaz:
https://doaj.org/article/8e5324444e6a4d10a487d5a6da243a6b
Autor:
Edessa Negera, Kidist Bobosha, Abraham Aseffa, Hazel M Dockrell, Diana N J Lockwood, Stephen L Walker
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 7, p e0010641 (2022)
BackgroundThe numbers of circulating regulatory T cells (Tregs) are increased in lepromatous leprosy (LL) but reduced in erythema nodosum leprosum (ENL), the inflammatory complication of LL. It is unclear whether the suppressive function of Tregs is
Externí odkaz:
https://doaj.org/article/0f05e2586303427a9298d1232c98812f
Autor:
Hazel M. Dockrell, Helen McShane
Publikováno v:
EBioMedicine, Vol 79, Iss , Pp 103993- (2022)
Summary: The Mycobacterium bovis BCG vaccine was first used in 1921, but has not controlled the global spread of tuberculosis (TB). There are still no new licensed tuberculosis vaccines, although there much active research and a vaccine development p
Externí odkaz:
https://doaj.org/article/41064a6c94454901a7db5b22fb0f8834
Autor:
Bugwesa Z. Katale, Peter M. Mbelele, Nsiande A. Lema, Susana Campino, Stephen E. Mshana, Mark M. Rweyemamu, Jody E. Phelan, Julius D. Keyyu, Mtebe Majigo, Erasto V. Mbugi, Hazel M. Dockrell, Taane G. Clark, Mecky I. Matee, Stellah Mpagama
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background Tuberculosis (TB), particularly multi- and or extensive drug resistant TB, is still a global medical emergency. Whole genome sequencing (WGS) is a current alternative to the WHO-approved probe-based methods for TB diagnosis and de
Externí odkaz:
https://doaj.org/article/c55d863df9e24229a9a04cdf63e7acde
Autor:
Shennae O'Boyle, Luis Nacul, Flavio E. Nacul, Kathleen Mudie, Caroline C. Kingdon, Jacqueline M. Cliff, Taane G. Clark, Hazel M. Dockrell, Eliana M. Lacerda
Publikováno v:
Frontiers in Medicine, Vol 8 (2022)
We propose a framework for the treatment, rehabilitation, and research into Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using a natural history of disease approach to outline the distinct disease stages, with an emphasis on cases foll
Externí odkaz:
https://doaj.org/article/3773f141a9bd480295c01a4bca797edf
Autor:
Bugwesa Z. Katale, Erasto V. Mbugi, Julius D. Keyyu, Robert D. Fyumagwa, Mark M. Rweyemamu, Paul D. van Helden, Hazel M. Dockrell, Mecky I. Matee
Publikováno v:
One Health Outlook, Vol 1, Iss 1, Pp 1-8 (2019)
Abstract Background One Health (OH) is an integrated approach, formed inclusive of using multiple disciplines to attain optimal health for humans, animals, and the environment. The increasing proximity between humans, livestock, and wildlife, and its
Externí odkaz:
https://doaj.org/article/d7da7d4b06f8450d91de7596615cc752
Autor:
Harriet D. Gliddon, Myrsini Kaforou, Mary Alikian, Dominic Habgood-Coote, Chenxi Zhou, Tolu Oni, Suzanne T. Anderson, Andrew J. Brent, Amelia C. Crampin, Brian Eley, Robert Heyderman, Florian Kern, Paul R. Langford, Tom H. M. Ottenhoff, Martin L. Hibberd, Neil French, Victoria J. Wright, Hazel M. Dockrell, Lachlan J. Coin, Robert J. Wilkinson, Michael Levin
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Recently, host whole blood gene expression signatures have been identified for diagnosis of tuberculosis (TB). Absolute quantification of the concentrations of signature transcripts in blood have not been reported, but would facilitate diagnostic tes
Externí odkaz:
https://doaj.org/article/179a6b2ee6174b478eec06f81b9547eb
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
BackgroundThe Beijing strain of Mycobacterium tuberculosis (M. tb) has been most frequently isolated from TB patients in South Korea, and the hyper-virulent Beijing/K genotype is associated with TB outbreaks. To examine the diagnostic potential of Be
Externí odkaz:
https://doaj.org/article/ea6b18a987be445aa26e63fd26d73c6c