Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Hazel Lum"'
Autor:
Zheng Xu, Weixin Li, Jibo Han, Chunpeng Zou, Weijian Huang, Weihui Yu, Xiaoou Shan, Hazel Lum, Xiaokun Li, Guang Liang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/f57d98bb4f454692862ac1cb5daec3f3
Autor:
Yi Wang, Wu Luo, Jibo Han, Zia A. Khan, Qilu Fang, Yiyi Jin, Xuemei Chen, Yali Zhang, Meihong Wang, Jianchang Qian, Weijian Huang, Hazel Lum, Gaojun Wu, Guang Liang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The mechanisms underlying cardiac inflammation in diabetic cardiomyopathy are incompletely understood. Here the authors show that advanced glycation end products bind to the TLR4 co-receptor MD2 initiating pro-inflammatory pathways.
Externí odkaz:
https://doaj.org/article/7ae086d521474d0c9dfe695bbcf6dabd
Autor:
Xiaoou Shan, Wu Luo, Yi Wang, Huiping Zhou, Zheng Xu, Weihui Yu, Xinfu Guan, Yuanyuan Qian, Xiaohong Xu, Sujing Xu, Hazel Lum
Publikováno v:
The Journal of Nutritional Biochemistry. 70:47-55
There is a strong epidemiological link between obesity, a growing worldwide concern, and kidney disease. Emerging evidence indicates that the pathogenic basis of obesity-related kidney disease may be attributed to Toll-like receptor 4 (TLR4) of the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c538a0b4b367b7b1039d308579e0fb09
https://doi.org/10.1016/j.jnutbio.2019.04.003
https://doi.org/10.1016/j.jnutbio.2019.04.003
Autor:
Lingfeng Chen, Jianzhang Wu, Hazel Lum, Yali Zhang, Yunjie Zhao, Guang Liang, Zhongxiang Xiao, Bin Bai, Hong Zhang, Hongjin Chen, Zhiguo Liu, Yi Wang
Publikováno v:
European Journal of Medicinal Chemistry. 148:291-305
An overactive Toll-like receptor (TLR) signaling complex is a significant pathogenic factor of acute and chronic inflammatory diseases. The natural product curcumin is reported to inhibit the TLR4 co-receptor, MD2 (myeloid differentiation protein 2),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950bc0304b6b0b11c20b12c875c236fb
https://doi.org/10.1016/j.ejmech.2018.02.008
https://doi.org/10.1016/j.ejmech.2018.02.008
Autor:
Jingying Wang, Lintao Wang, Guang Liang, Daona Yang, Yali Zhang, Hazel Lum, Xiong Chen, Yi Wang, Peng Zhong, Xiaoou Shan, Qilu Fang
Publikováno v:
Journal of Cellular and Molecular Medicine
Obesity is a major and independent risk factor of kidney diseases. The pathogenic mechanisms of obesity‐associated renal injury are recognized to at least involve a lipid‐rich and pro‐inflammatory state of the renal tissues, but specific mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22d441efa53834b47303976abf82494
https://doi.org/10.1111/jcmm.13287
https://doi.org/10.1111/jcmm.13287
Autor:
Hazel Lum, Di Wu, Jianmin Zhou, Ruijie Chen, Hongjin Chen, Guang Liang, Chuchu Sun, Hui Liu, Yali Zhang, Bin Bai, Zhongxiang Xiao, Wenxin Zhang, Bing Zhang
Publikováno v:
Phytomedicine : international journal of phytotherapy and phytopharmacology. 63
Background ALI/ARDS is characterized by severe hypoxemic respiratory failure attributed to inflammatory tissue injury. There are no treatment modalities able to prevent/reverse the dire pathological sequelae in these patients. Evidence links the infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b16adb1cb626ecced6948d1ae161e59
https://pubmed.ncbi.nlm.nih.gov/31254764
https://pubmed.ncbi.nlm.nih.gov/31254764
Autor:
Guang Liang, Hazel Lum, Xiaoou Shan, Weijian Huang, Zheng Xu, Weixin Li, Jibo Han, Chunpeng Zou, Xiaokun Li, Weihui Yu
Publikováno v:
Scientific Reports
Growing evidence indicates that angiotensin II (Ang II), a potent biologically active product of RAS, is a key regulator of renal inflammation and fibrosis. In this study, we tested the hypothesis that Ang II induces renal inflammatory injury and fib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d52539a1717a38ad25c1ddadd58df7
https://doi.org/10.1038/srep44911
https://doi.org/10.1038/srep44911
Publikováno v:
Endocrinology
We previously reported that genistein, a phytoestrogen, up-regulates endothelial nitric oxide synthase (eNOS) and prevents hypertension in rats that are independent of estrogen signaling machinery. However, how genistein regulates eNOS expression is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c67df1afc60deae322b7c8f94af4874
http://europepmc.org/articles/PMC3791435
http://europepmc.org/articles/PMC3791435
Publikováno v:
American Journal of Physiology-Cell Physiology. 295:C1161-C1168
The cAMP-PKA cascade is a recognized signaling pathway important in inhibition of inflammatory injury events such as endothelial permeability and leucocyte trafficking, and a critical target of regulation is believed to be inhibition of Rho proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959c9e0641a42207a64c28641787462f
https://doi.org/10.1152/ajpcell.00139.2008
https://doi.org/10.1152/ajpcell.00139.2008
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 85:281-288
We investigated the activity of P21-activated kinase-1 (Pak1) on myosin light chain phosphorylation and on thrombin-induced barrier dysfunction in human endothelial cells (HMEC). HMEC were infected with recombinant adenoviruses that express constitut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89e9047bfd9da96064cc5faf0550ce5a
https://doi.org/10.1139/y06-100
https://doi.org/10.1139/y06-100