Evidence for a fragile X messenger ribonucleoprotein 1 ( FMR1 ) mRNA gain‐of‐function toxicity mechanism contributing to the pathogenesis of fragile X‐associated premature ovarian insufficiency

Autor: Roseanne Rosario, Hazel L. Stewart, Nila Roy Choudhury, Gracjan Michlewski, Nicholas Charlet‐Berguerand, Richard A. Anderson

Publikováno v: Rosario, R, Stewart, H L, Roy Choudhury, N, Michlewski, G, Charlet-Berguerand, N & Anderson, R A 2022, ' Evidence for a fragile X messenger ribonucleoprotein 1 (FMR1) mRNA gain-of-function toxicity mechanism contributing to the pathogenesis of fragile X-associated premature ovarian insufficiency ', The FASEB Journal, vol. 36, no. 11, e22612 . https://doi.org/10.1096/fj.202200468RR

Fragile X-associated premature ovarian insufficiency (FXPOI) is among a family of disorders caused by expansion of a CGG trinucleotide repeat sequence located in the 5’ untranslated region (UTR) of the fragile X messenger ribonucleoprotein 1 (FMR1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f79bba0dfaa9fcf907138b7ee1e440
https://doi.org/10.1096/fj.202200468rr

Reduced retinoic acid synthesis accelerates prophase I and follicle activation

Autor: Emily Walshe, Richard A. Anderson, Hazel L Stewart, Roseanne Rosario

Publikováno v: Rosario, R, Stewart, H L, Walshe, E & Anderson, R A 2020, ' Reduced retinoic acid synthesis accelerates prophase I and follicle activation ', Reproduction . https://doi.org/10.1530/REP-20-0221
Reproduction (Cambridge, England)

In female mammals, reproductive potential is determined during fetal life by the formation of a non-renewable pool of primordial follicles. Initiation of meiosis is one of the defining features of germ cell differentiation and is well established to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fcc29818f3ad3915e95d95e48efb79
https://www.pure.ed.ac.uk/ws/files/172592589/_17417899_Reproduction_Reduced_retinoic_acid_synthesis_accelerates_prophase_I_and_follicle_activation.pdf

Characterization of single channel liquid light guide coupling and SPAD array imaging for tumour margin estimation using fluorescence lifetime

Autor: David J. S. Birch, Hazel L Stewart, Graham Hungerford

Publikováno v: Measurement Science and Technology. 31:125701

Surgery remains one of the key treatment options for tumour removal, and surgeons primarily rely on eye and touch to assess the boundary between healthy and cancerous tissue with no cellular information as guidance. There is therefore a need for a de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecfcd494d834a23e7c15646dcb26898
https://doi.org/10.1088/1361-6501/aba5c6

Nanoparticle metrology of silica colloids and super-resolution studies using the ADOTA fluorophore

Autor: Martin Rosenberg, Philip Yip, Thomas Just Sørensen, Hazel L Stewart, Bo W. Laursen, David J. S. Birch, Alex E. Knight

We describe how a new fluorescent dye, methyl ADOTA (N-methyl-azadioxatriangulenium tetrafluoroborate), is an improvement on dyes reported previously for measuring silica nanoparticle size in sols using the decay of fluorescence anisotropy. Me(thyl)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c928051038361171bf37a7bd830d4eb4
https://strathprints.strath.ac.uk/55866/1/Stewart_etal_MST_2016_Nanoparticle_metrology_of_silica_colloids_and_super_resolution.pdf