Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hazel L. Kinnell"'
Autor:
Rosemary A L Bayne, Hazel L Kinnell, Shiona M Coutts, Jing He, Andrew J Childs, Richard A Anderson
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119819 (2015)
During human fetal ovary development, the process of primordial follicle formation is immediately preceded by a highly dynamic period of germ cell and somatic cell reorganisation. This is regulated by germ-cell specific transcription regulators, by t
Externí odkaz:
https://doaj.org/article/e3702f6da7854075b838c227c967632c
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136009 (2015)
Externí odkaz:
https://doaj.org/article/94589f548d2841089cf398507312c3bf
Autor:
Paul B Comish, Ana Luiza Drumond, Hazel L Kinnell, Richard A Anderson, Angabin Matin, Marvin L Meistrich, Gunapala Shetty
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93311 (2014)
Exposure to radiation during fetal development induces testicular germ cell tumors (TGCT) and reduces spermatogenesis in mice. However, whether DNA damaging chemotherapeutic agents elicit these effects in mice remains unclear. Among such agents, cycl
Externí odkaz:
https://doaj.org/article/46f27dca5a4e46849f8299f3377c0081
Publikováno v:
PLoS ONE, Vol 8, Iss 11 (2013)
[This corrects the article DOI: 10.1371/journal.pone.0073996.].
Externí odkaz:
https://doaj.org/article/3e5210d4022343c49fce31e322680c96
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73996 (2013)
The Deleted in Azoospermia gene family encodes three germ cell-specific RNA-binding proteins (DAZ, DAZL and BOLL) that are essential for gametogenesis in diverse species. Targeted disruption of Boll in mice causes male-specific spermiogenic defects,
Externí odkaz:
https://doaj.org/article/2ab763f3c2da4778870031a66061fb79
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20249 (2011)
The development of mammalian fetal germ cells along oogenic or spermatogenic fate trajectories is dictated by signals from the surrounding gonadal environment. Germ cells in the fetal testis enter mitotic arrest, whilst those in the fetal ovary under
Externí odkaz:
https://doaj.org/article/3b56bb9bc6814afdb77ef5478b07358c
Autor:
Sharon L. Eddie, Pamela Brown, Hazel L. Kinnell, Andrew J. Childs, Henry N. Jabbour, Richard A. Anderson
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:E1197-E1205
Fetal ovarian development and primordial follicle formation underpin future female fertility. Prokineticin (PROK) ligands regulate cell survival, proliferation, and angiogenesis in adult reproductive tissues including the ovary. However, their expres
Autor:
Rosemary A, Bayne, Douglas J, Donnachie, Hazel L, Kinnell, Andrew J, Childs, Richard A, Anderson
Publikováno v:
Molecular Human Reproduction
STUDY QUESTION Do changes in the expression of bone morphogenetic proteins (BMPs) 2 and 4, and their antagonists Gremlin1 (GREM1) and Gremlin2 (GREM2) during human fetal ovarian development impact on BMP pathway activity and lead to changes in gene e
Autor:
Hazel L. Kinnell, R A L Bayne, Sharon L. Eddie, Chris McKinnell, Ana Calarrao, Thomas Chambers, Elke Wolfinger, Pablo Hurtado-Gonzalez, Afshan Dean, Richard M. Sharpe, Yili Wang, Lenka Hrabalkova, Casper P. Hagen, Sheila Macpherson, Sander van den Driesche, Richard A. Anderson, Kerrie Stevenson, Rod T. Mitchell
Publikováno v:
Scientific Reports
Dean, A, Van Den Driesche, S, Wang, Y, Mckinnell, C, Macpherson, S, Eddie, S L, Kinnell, H, Hurtado-gonzalez, P, Chambers, T J, Stevenson, K, Wolfinger, E, Hrabalkova, L, Calarrao, A, Bayne, R A, Hagen, C P, Mitchell, R T, Anderson, R A & Sharpe, R M 2016, ' Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences ', Scientific Reports, vol. 6, pp. 19789 . https://doi.org/10.1038/srep19789
Dean, A, van den Driesche, S, Wang, Y, McKinnell, C, Macpherson, S, Eddie, S L, Kinnell, H, Hurtado-Gonzalez, P, Chambers, T J, Stevenson, K, Wolfinger, E, Hrabalkova, L, Calarrao, A, Bayne, R A, Hagen, C P, Mitchell, R T, Anderson, R A & Sharpe, R M 2016, ' Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences ', Scientific Reports, vol. 6, 19789 . https://doi.org/10.1038/srep19789
Dean, A, Van Den Driesche, S, Wang, Y, Mckinnell, C, Macpherson, S, Eddie, S L, Kinnell, H, Hurtado-gonzalez, P, Chambers, T J, Stevenson, K, Wolfinger, E, Hrabalkova, L, Calarrao, A, Bayne, R A, Hagen, C P, Mitchell, R T, Anderson, R A & Sharpe, R M 2016, ' Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences ', Scientific Reports, vol. 6, pp. 19789 . https://doi.org/10.1038/srep19789
Dean, A, van den Driesche, S, Wang, Y, McKinnell, C, Macpherson, S, Eddie, S L, Kinnell, H, Hurtado-Gonzalez, P, Chambers, T J, Stevenson, K, Wolfinger, E, Hrabalkova, L, Calarrao, A, Bayne, R A, Hagen, C P, Mitchell, R T, Anderson, R A & Sharpe, R M 2016, ' Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences ', Scientific Reports, vol. 6, 19789 . https://doi.org/10.1038/srep19789
Analgesics which affect prostaglandin (PG) pathways are used by most pregnant women. As germ cells (GC) undergo developmental and epigenetic changes in fetal life and are PG targets, we investigated if exposure of pregnant rats to analgesics (indomet
Autor:
Richard A. Anderson, Rosemary A.L. Bayne, Craig S. Collins, Hazel L. Kinnell, Andrew J. Childs, Kirsten Hogg, Alan S. McNeilly, Samira J. Green
Publikováno v:
Stem Cells (Dayton, Ohio)
Childs, A J, Kinnell, H L, Collins, C S, Hogg, K, Bayne, R A L, Green, S J, McNeilly, A S & Anderson, R A 2010, ' BMP Signaling in the Human Fetal Ovary is Developmentally Regulated and Promotes Primordial Germ Cell Apoptosis ', STEM CELLS, vol. 28, no. 8, pp. 1368-1378 . https://doi.org/10.1002/stem.440
Childs, A J, Kinnell, H L, Collins, C S, Hogg, K, Bayne, R A L, Green, S J, McNeilly, A S & Anderson, R A 2010, ' BMP Signaling in the Human Fetal Ovary is Developmentally Regulated and Promotes Primordial Germ Cell Apoptosis ', STEM CELLS, vol. 28, no. 8, pp. 1368-1378 . https://doi.org/10.1002/stem.440
Primordial germ cells (PGCs) are the embryonic precursors of gametes in the adult organism, and their development, differentiation, and survival are regulated by a combination of growth factors collectively known as the germ cell niche. Although many