GDF9 is transiently expressed in oocytes before follicle formation in the human fetal ovary and is regulated by a novel NOBOX transcript.

Autor: Rosemary A L Bayne, Hazel L Kinnell, Shiona M Coutts, Jing He, Andrew J Childs, Richard A Anderson

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119819 (2015)

During human fetal ovary development, the process of primordial follicle formation is immediately preceded by a highly dynamic period of germ cell and somatic cell reorganisation. This is regulated by germ-cell specific transcription regulators, by t

Externí odkaz: https://doaj.org/article/e3702f6da7854075b838c227c967632c

Fetal cyclophosphamide exposure induces testicular cancer and reduced spermatogenesis and ovarian follicle numbers in mice.

Autor: Paul B Comish, Ana Luiza Drumond, Hazel L Kinnell, Richard A Anderson, Angabin Matin, Marvin L Meistrich, Gunapala Shetty

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93311 (2014)

Exposure to radiation during fetal development induces testicular germ cell tumors (TGCT) and reduces spermatogenesis in mice. However, whether DNA damaging chemotherapeutic agents elicit these effects in mice remains unclear. Among such agents, cycl

Externí odkaz: https://doaj.org/article/46f27dca5a4e46849f8299f3377c0081

A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice.

Autor: Jing He, Kayleigh Stewart, Hazel L Kinnell, Richard A Anderson, Andrew J Childs

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e73996 (2013)

The Deleted in Azoospermia gene family encodes three germ cell-specific RNA-binding proteins (DAZ, DAZL and BOLL) that are essential for gametogenesis in diverse species. Targeted disruption of Boll in mice causes male-specific spermiogenic defects,

Externí odkaz: https://doaj.org/article/2ab763f3c2da4778870031a66061fb79

Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression ofCOX2

Autor: Sharon L. Eddie, Pamela Brown, Hazel L. Kinnell, Andrew J. Childs, Henry N. Jabbour, Richard A. Anderson

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 100:E1197-E1205

Fetal ovarian development and primordial follicle formation underpin future female fertility. Prokineticin (PROK) ligands regulate cell survival, proliferation, and angiogenesis in adult reproductive tissues including the ovary. However, their expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93093568c70e8b9cc93fdcbe1288b667
https://doi.org/10.1210/jc.2015-2330

BMP Signaling in the Human Fetal Ovary is Developmentally Regulated and Promotes Primordial Germ Cell Apoptosis

Autor: Richard A. Anderson, Rosemary A.L. Bayne, Craig S. Collins, Hazel L. Kinnell, Andrew J. Childs, Kirsten Hogg, Alan S. McNeilly, Samira J. Green

Publikováno v: Stem Cells (Dayton, Ohio)
Childs, A J, Kinnell, H L, Collins, C S, Hogg, K, Bayne, R A L, Green, S J, McNeilly, A S & Anderson, R A 2010, ' BMP Signaling in the Human Fetal Ovary is Developmentally Regulated and Promotes Primordial Germ Cell Apoptosis ', STEM CELLS, vol. 28, no. 8, pp. 1368-1378 . https://doi.org/10.1002/stem.440

Primordial germ cells (PGCs) are the embryonic precursors of gametes in the adult organism, and their development, differentiation, and survival are regulated by a combination of growth factors collectively known as the germ cell niche. Although many

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250059e0373aba2385748868aab4f4eb
http://europepmc.org/articles/PMC2964513