Výsledky vyhledávání - "Hazel England"

Akademický článek

Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression

Autor: Polly Downton, James S. Bagnall, Hazel England, David G. Spiller, Neil E. Humphreys, Dean A. Jackson, Pawel Paszek, Michael R. H. White, Antony D. Adamson

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Cells respond to inflammatory stimuli such as cytokines by activation of the nuclear factor-κB (NF-κB) signalling pathway, resulting in oscillatory translocation of the transcription factor p65 between nucleus and cytoplasm in some cell types. We i

Externí odkaz: https://doaj.org/article/0ae9f541650a4de1829a089cf962e69c

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Akademický článek

Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses

Autor: Stamatia Papoutsopoulou, Lorna Morris, Andrew Bayliff, Thomas Mair, Hazel England, Massimiliano Stagi, François Bergey, Mohammad Tauqeer Alam, Raheleh Sheibani-Tezerji, Philip Rosenstiel, Werner Müller, Vitor A. P. Martins Dos Santos, Barry J. Campbell

Publikováno v: Biomedicines, Vol 10, Iss 4, p 757 (2022)

The NFκB transcription factors are major regulators of innate immune responses, and NFκB signal pathway dysregulation is linked to inflammatory disease. Here, we utilised bone marrow-derived macrophages from the p65-DsRedxp/IκBα-eGFP transgenic s

Externí odkaz: https://doaj.org/article/4166ff8a12b24b59adc6b5384f9cae5f

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Akademický článek

Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease

Publikováno v: Disease Models & Mechanisms, Vol 13, Iss 11 (2020)

Inflammatory bowel diseases (IBDs) cause significant morbidity and mortality. Aberrant NF-κB signalling is strongly associated with these conditions, and several established drugs influence the NF-κB signalling network to exert their effect. This s

Externí odkaz: https://doaj.org/article/98e510497b174f5483defce389417b32

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Akademický článek

Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients

Autor: Stamatia Papoutsopoulou, Michael D. Burkitt, François Bergey, Hazel England, Rachael Hough, Lorraine Schmidt, David G. Spiller, Michael H. R. White, Pawel Paszek, Dean A. Jackson, Vitor A. P. Martins Dos Santos, Gernot Sellge, D. Mark Pritchard, Barry J. Campbell, Werner Müller, Chris S. Probert

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation of the NF-κB transcription factor is a highly regulated, dynamic event in IBD pathogenesis. Using a lentivirus approach,

Externí odkaz: https://doaj.org/article/d581931c5d434a78a70223703dfa1143

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Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease

Autor: Hazel England, Emily Smith, Carrie A. Duckworth, Lorna Morris, Chris Probert, Barry J. Campbell, Katie A. Lloyd, Vitor A. P. Martins dos Santos, Stamatia Papoutsopoulou, Mike Hr White, Francois Bergey, Madeleine Kittner, Werner Müller, D. Mark Pritchard, Michael D. Burkitt, Vladimir Poroikov, Alexander E. Kel, Dave Spiller, Philip Stegmaier

Publikováno v: Disease Models & Mechanisms
article-version (VoR) Version of Record
DISEASE MODELS & MECHANISMS
Disease Models & Mechanisms, Vol 13, Iss 11 (2020)
SysmedIBD consortium, Lloyd, K, Papoutsopoulou, S, Smith, E, Stegmaier, P, Bergey, F, Morris, L, Kittner, M, England, H, Spiller, D, White, M, Campbell, B J, Duckworth, C A, Poroikov, V, Martins dos Santos, V AP, Kel, A, Muller, W, Pritchard, D M, Probert, C & Burkitt, M D 2020, ' Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease ', DMM Disease Models and Mechanisms . https://doi.org/10.1242/dmm.044040
Disease models & mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651df354d20b7284c4736aee643dd192
https://pubmed.ncbi.nlm.nih.gov/32958515

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Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling

Autor: Pawel Paszek, Christopher M. Clark, Dean A. Jackson, Nissrin Alachkar, James Bagnall, James Roberts, Mark Muldoon, Hazel England, Mark Platt, William Rowe

Publikováno v: Bagnall, J, Rowe, W, Alachkar, N, Roberts, J, England, H, Clark, C, Platt, M, Jackson, D, Muldoon, M & Paszek, P 2020, ' Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling ', Cell Systems, vol. 11, no. 3, pp. 300-314.e8 . https://doi.org/10.1016/j.cels.2020.08.007

Summary Single-cell gene expression is inherently variable, but how this variability is controlled in response to stimulation remains unclear. Here, we use single-cell RNA-seq and single-molecule mRNA counting (smFISH) to study inducible gene express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895227e99b0e9bf89e5f102871fee92e
https://doi.org/10.1016/j.cels.2020.08.007

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Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation

Publikováno v: Bagnall, J, Boddington, C, England, H, Brignall, R, Downton, P, Alsoufi, Z, Boyd, J, Rowe, W, Bennett, A, Walker, C, Adamson, A, Patel, N, O'Cualain, R, Schmidt, L, Spiller, D, Jackson, D, Muller, W, Muldoon, M, White, M & Paszek, P 2018, ' Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation ', Science Signaling, vol. 11, no. 540, eaaf3998 . https://doi.org/10.1126/scisignal.aaf3998

Toll-like receptor (TLR) signaling regulates macrophage activation and effector cytokine propagation in the constrained environment of a tissue. In macrophage populations, TLR4 stimulates the dose-dependent transcription of nuclear factor B (NF-�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6ecc759bca55be0a974323a0affaca
https://doi.org/10.1126/scisignal.aaf3998

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Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death

Autor: David Brough, Nancy J. Rothwell, Holly R. Summersgill, Hazel England, Michelle E. Edye

Publikováno v: The Journal of Biological Chemistry
England, H, Summersgill, H, Edye, M, Rothwell, N & Brough, D 2014, ' Release of interleukin-1 α or interleukin-1 β depends on mechanism of cell death ', Journal of Biological Chemistry, vol. 289, no. 23, pp. 15942-15950 . https://doi.org/10.1074/jbc.M114.557561

Background: Cell death is a regulator of inflammation via the master cytokine IL-1. Results: Apoptotic stimuli induced a caspase-8-dependent release of IL-1β from macrophages. Necroptotic stimuli induced a calpain-dependent release of IL-1α. Conclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbcb59a16302acc6fdd192a297eb0eb
https://doi.org/10.1074/jbc.m114.557561

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