Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hazel A Cruickshanks"'
Autor:
Natasha Vafadar-Isfahani, Christina Parr, Lara E. McMillan, Juliane Sanner, Zhao Yeo, Stephen Saddington, Oliver Peacock, Hazel A. Cruickshanks, Richard R. Meehan, Jonathan N. Lund, Cristina Tufarelli
Publikováno v:
Epigenetics, Vol 12, Iss 6, Pp 465-475 (2017)
Hypomethylation of LINE-1 repeats in cancer has been proposed as the main mechanism behind their activation; this assumption, however, was based on findings from early studies that were biased toward young and transpositionally active elements. Here,
Externí odkaz:
https://doaj.org/article/f907f7c21c7b4b1a989f4df3bb579786
Autor:
Neil Robertson, Douglas J. MacKenzie, Peter D. Adams, Claire Reid, Tony McBryan, Andrew Hodges, Karen Blyth, Iqbal Rather, Hazel A Cruickshanks, Gintare Sendzikaite, Catrin Pritchard
Publikováno v:
iScience
iScience, Vol 23, Iss 2, Pp-(2020)
iScience, Vol 23, Iss 2, Pp-(2020)
Summary Approximately 10% of human colorectal cancer (CRC) are associated with activated BRAFV600E mutation, typically in absence of APC mutation and often associated with a CpG island methylator (CIMP) phenotype. To protect from cancer, normal intes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6139a812c7c4aa427f4f787a9104601e
https://pubmed.ncbi.nlm.nih.gov/32058953
https://pubmed.ncbi.nlm.nih.gov/32058953
Autor:
Greg Donahue, John van Tuyn, Nathan D. VanderKraats, Peter D. Adams, Tony McBryan, Shelley L. Berger, Parisha P. Shah, Donncha S. Dunican, Richard R. Meehan, Mark E. Drotar, Taranjit Singh Rai, John R. Edwards, David M. Nelson, Hazel A Cruickshanks, Claire Brock
Publikováno v:
Nature Cell Biology. 15:1495-1506
Altered DNA methylation and associated destabilization of genome integrity and function is a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes a limit on the proliferative potential of normal cells that all cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23f8939ab40af0ec4f6ca47759c2b84
https://doi.org/10.1038/ncb2879
https://doi.org/10.1038/ncb2879
Publikováno v:
Genomics. 94(6):397-406
The antisense promoter of human LINE-1 (L1) retroelements can direct transcription of adjacent unique genomic sequences generating chimeric RNAs, which can perturb transcription of neighbouring genes. As L1 elements constitute 17% of the human genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55088d94e911951630810d67156598dc
Autor:
Colm E, Nestor, Raffaele, Ottaviano, Diana, Reinhardt, Hazel A, Cruickshanks, Heidi K, Mjoseng, Rhoanne C, McPherson, Antonio, Lentini, John P, Thomson, Donncha S, Dunican, Sari, Pennings, Stephen M, Anderton, Mikael, Benson, Richard R, Meehan
Publikováno v:
Genome Biology
Background The DNA methylation profiles of mammalian cell lines differ from those of the primary tissues from which they were derived, exhibiting increasing divergence from the in vivo methylation profile with extended time in culture. Few studies ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bca42bb5ef8a51cef37dd00cbdde200c
https://pubmed.ncbi.nlm.nih.gov/25648825
https://pubmed.ncbi.nlm.nih.gov/25648825
Autor:
Masako Suzuki, Ian R. Adams, Donncha S. Dunican, Robert J. Arceci, Colin A. Semple, John M. Greally, Hazel A Cruickshanks, Tracey Davey, Richard R. Meehan
Publikováno v:
Dunican, D S, Cruickshanks, H A, Suzuki, M, Semple, C A, Davey, T, Arceci, R J, Greally, J, Adams, I R & Meehan, R R 2013, ' Lsh regulates LTR retrotransposon repression independently of Dnmt3b function ', Genome Biology, vol. 14, no. 12, pp. R146 . https://doi.org/10.1186/gb-2013-14-12-r146
Genome Biology
Genome Biology
Background: DNA methylation contributes to genomic integrity by suppressing repeat-associated transposition. In addition to the canonical DNA methyltransferases, several auxiliary chromatin factors are required to maintain DNA methylation at intergen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120a7450c19bea331523a69be826ee13
https://hdl.handle.net/20.500.11820/44abc88f-92c0-4cdf-a916-16fba70299cd
https://hdl.handle.net/20.500.11820/44abc88f-92c0-4cdf-a916-16fba70299cd
The ability of active retrotransposon elements to move within the host genome and alter gene expression with subsequent phenotypic variation led to their initial discovery. In recent years it has become apparent that these elements can also modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd74b00921f49d79988d5691d65e6d6
https://europepmc.org/articles/PMC3827066/
https://europepmc.org/articles/PMC3827066/
Autor:
Hazel A Cruickshanks, Duncan Sproul, Richard R. Meehan, Jonathan N. Lund, Andrew Lee, Donncha S. Dunican, Natasha Vafadar-Isfahani, Cristina Tufarelli
Publikováno v:
Cruickshanks, H A, Vafadar-Isfahani, N, Dunican, D S, Lee, A, Sproul, D, Lund, J N, Meehan, R & Tufarelli, C 2013, ' Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer ', Nucleic Acids Research, vol. 41, no. 14, pp. 6857-6869 . https://doi.org/10.1093/nar/gkt438
Nucleic Acids Research
Nucleic Acids Research
LINE-1 retrotransposons are abundant repetitive elements of viral origin, which in normal cells are kept quiescent through epigenetic mechanisms. Activation of LINE-1 occurs frequently in cancer and can enable LINE-1 mobilization but also has retrotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2ca5daeef1c45e9872ecd65db0a9cb
https://www.pure.ed.ac.uk/ws/files/9089398/Expression_of_a_large_LINE_1_driven_antisense_RNA_is_linked_to_epigenetic_silencing_of_the_metastasis_suppressor_gene_TFPI_2_in_cancer.pdf
https://www.pure.ed.ac.uk/ws/files/9089398/Expression_of_a_large_LINE_1_driven_antisense_RNA_is_linked_to_epigenetic_silencing_of_the_metastasis_suppressor_gene_TFPI_2_in_cancer.pdf
Autor:
Hazel A Cruickshanks, Peter D. Adams
Publikováno v:
Current opinion in geneticsdevelopment. 21(1)
To prevent cancer, mammals have evolved potent tumor suppression mechanisms, including senescence and apoptosis. These processes depend on regulation of chromatin. Chromatin-dependent tumor suppressor pathways are activated in pre-malignant cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37993f339827028bd9a1bab47ca6e19
https://pubmed.ncbi.nlm.nih.gov/21087854
https://pubmed.ncbi.nlm.nih.gov/21087854