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Akademický článek
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Publikováno v:
Humanexperimental toxicology. 40(2)
Disorders of the endoplasmic reticulum (ER) lead to cellular damage but can cause cell death if ER dysfunction is prolonged. We aimed to examine liver/kidney functions, neutral sphingomyelinase (N-SMase) activity, sphingolipid levels, cytosolic phosp
Akademický článek
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Autor:
Sabriye Kaya, Bahar Akkaya, Nesil Coskunfirat, Ozlem Elpek, Ilker Onguc Aycan, Hazal Tuzcu, Mutay Aslan, Ebru Kirac
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 118
The aim of this study was to investigate whether thymoquinone (TQ) could alleviate diclofenac (DCLF)-induced gastrointestinal and renal toxicity in rats. Diclofenac was administered via intramuscular injection twice daily for 5 days and TQ was given
Autor:
Balaban, Hazal Tuzcu
Amaç: Önceki çalışmalar karaciğer (KC) ılık iskemi reperfüzyon (IR) hasarından sonra nötral sfingomyelinaz (N-SMase)/seramid yolağının hepatik dokuda aktive olduğunu göstermiştir. Fazla miktarda seramid birikiminin apoptotik stimulus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3311::b8ba1a47410287bef13b42d4eb3b0a75
http://acikerisim.akdeniz.edu.tr/xmlui/handle/123456789/4074
http://acikerisim.akdeniz.edu.tr/xmlui/handle/123456789/4074
Publikováno v:
Humanexperimental toxicology. 37(8)
The aim of this study was to evaluate hepatic polyunsaturated fatty acids (PUFAs) and inflammatory response in an animal and cell model of endoplasmic reticulum (ER) stress. Rats were divided into control, tunicamycin (TM)-treated, and TM + taurourso
Publikováno v:
Molecular Medicine Reports
The aim of the present study was to assess omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) in liver tissue and evaluate changes in the n-6-associated inflammatory pathway following liver ischemia/re-perfusion (IR) injury. Male Wis
Publikováno v:
Human & Experimental Toxicology; Feb2021, Vol. 40 Issue 2, p259-273, 15p
Autor:
Esma Konuk, Betül Ünal, Gülsüm Özlem Elpek, Ebru Kirac, Necdet Demir, Mutay Aslan, Filiz Ozcan, Hazal Tuzcu
Publikováno v:
Free radical research. 51(3)
Previous studies have revealed the activation of neutral sphingomyelinase (N-SMase)/ceramide pathway in hepatic tissue following warm liver ischemia reperfusion (IR) injury. Excessive ceramide accumulation is known to potentiate apoptotic stimuli and
Publikováno v:
Redox report : communications in free radical research. 22(4)
Oxidative stress and excessive nitric oxide production via induction of inducible nitric oxide synthase (NOS)-2 have been shown in the pathogenesis of liver ischemia-reperfusion (IR) injury. Neutral sphingomyelinase (N-SMase)/ceramide pathway can reg