Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Haytham O. Tawfik"'
Autor:
Mahmoud G. Abo Al-Hamd, Haytham O. Tawfik, Omeima Abdullah, Koki Yamaguchi, Masaharu Sugiura, Ahmed B. M. Mehany, Mervat H. El-Hamamsy, Tarek F. El-Moselhy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new series of anticancer agents. Thirty-two new compounds were synthesised where x-ray crystallography was performed to confirm enantiomerism. Thirteen compounds showe
Externí odkaz:
https://doaj.org/article/9056c1dbec114abe9db25e676a2af1f4
Autor:
Moataz A. Shaldam, Hadia Almahli, Andrea Angeli, Rehab Mustafa Badi, Eman F. Khaleel, Abdelrahman I. Zain-Alabdeen, Zainab M. Elsayed, Eslam B. Elkaeed, Rofaida Salem, Claudiu T. Supuran, Wagdy M. Eldehna, Haytham O. Tawfik
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer activities. Firstly, all target isatins were examined for in vitro antitumor a
Externí odkaz:
https://doaj.org/article/a573ab6ca22e465f839233e88660bc72
Autor:
Faten Farouk, Ayman Abo Elmaaty, Ahmed Elkamhawy, Haytham O. Tawfik, Radwan Alnajjar, Mohammed A. S. Abourehab, Mohamed A. Saleh, Wagdy M. Eldehna, Ahmed A. Al‐Karmalawy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy. Numerous antibiotics could interact with biologically relevant macromolecules and provoke antitumor potential. Herein, molecular docking studies were used to investigate the
Externí odkaz:
https://doaj.org/article/a1c855bf5ade4c9380cb028408c47807
Autor:
Heba I. Ghamry, Amany Belal, Mohamed Kandeel El-Ashrey, Haytham O. Tawfik, Reem I. Alsantali, Ahmad J. Obaidullah, Ahmed A. El-Mansi, Doaa Abdelrahman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Researchers are constantly searching for drugs to combat the coronavirus pandemic caused by SARS-CoV-2, which has lasted for over two years. Natural compounds such as phenolic acids are being tested against Mpro and AAK1, which are key playe
Externí odkaz:
https://doaj.org/article/ee5e83ffa00a469ab9e7b7a27403f1f7
Publikováno v:
ACS Omega, Vol 8, Iss 8, Pp 7666-7683 (2023)
Externí odkaz:
https://doaj.org/article/d247816fb77243afa4a1d0ca645fb335
Autor:
Haytham O. Tawfik, Moataz A. Shaldam, Alessio Nocentini, Rofaida Salem, Hadia Almahli, Sara T. Al-Rashood, Claudiu T. Supuran, Wagdy M. Eldehna
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1043-1052 (2022)
Carbonic anhydrases (CAs) are one of the promising targets for the development of anticancer agents. CA isoforms are implicated in various physiological processes and are expressed in both normal and cancerous cells. Thus, non-isoform selective inhib
Externí odkaz:
https://doaj.org/article/79d3c232bc97466189f429543e2d6368
Autor:
Haytham O. Tawfik, Amany Belal, Mohammed A. S. Abourehab, Andrea Angeli, Alessandro Bonardi, Claudiu T. Supuran, Mervat H. El-Hamamsy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2765-2785 (2022)
Herein we reported the design and synthesis of two series comprising twenty-two benzenesulfonamides that integrate the s-triazine moiety. Target compounds successfully suppressed the hCA IX, with IC50 ranging from 28.6 to 871 nM. Compounds 5d, 11b, 5
Externí odkaz:
https://doaj.org/article/077bd5f5fb604ab5952b7cb61e728bdf
Autor:
Mohamed H. Saad, Tarek F. El-Moselhy, Nabaweya S, El-Din, Ahmed B. M. Mehany, Amany Belal, Mohammed A. S. Abourehab, Haytham O. Tawfik, Mervat H. El-Hamamsy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2489-2511 (2022)
Two new series of symmetric (1a-h) and asymmetric (2a-l) 1,4-DHP derivatives were designed, synthesised, and evaluated as anticancer agents. In vitro anticancer screening of target compounds via National cancer institute “NCI” revealed that analo
Externí odkaz:
https://doaj.org/article/08c13f6eb467482ba301125ea5211ccd
Autor:
Duaa Eliwa, Amal Kabbash, Mona El-Aasr, Haytham O. Tawfik, Gaber El-Saber Batiha, Mohamed H. Mahmoud, Michel De Waard, Wagdy M. Eldehna, Abdel-Rahim S. Ibrahim
Publikováno v:
Molecules, Vol 28, Iss 4, p 1583 (2023)
Bioconversion of biosynthetic heterocyclic compounds has been utilized to produce new semisynthetic pharmaceuticals and study the metabolites of bioactive drugs used systemically. In this investigation, the biotransformation of natural heterocyclic a
Externí odkaz:
https://doaj.org/article/f088df63dc8348728a13d0fca613ee52
Autor:
Hosam M. El-Seadawy, Kamilia A. Abo El-Seoud, Mona El-Aasr, Haytham O. Tawfik, Wagdy M. Eldehna, Amany E. Ragab
Publikováno v:
Metabolites, Vol 13, Iss 1, p 10 (2022)
Toxoplasmosis and cancer are life-threatening diseases with worldwide distribution. However, currently used chemosynthetic treatments are not devoid of their own intrinsic problems. Natural metabolites are gaining attention due to their lower side ef
Externí odkaz:
https://doaj.org/article/3b634da1aab045e883572eb623a91e4d