DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer

Autor: Eyad Elkord, Anne John, Varun Sasidharan Nair, Rowaida Z. Taha, Bassam R. Ali, Haytham El Salhat

Publikováno v: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-12 (2018)
Clinical Epigenetics
Sasidharan Nair, V, El Salhat, H, Taha, R Z, John, A, Ali, B R & Elkord, E 2018, ' DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer ', Clinical Epigenetics, vol. 10, no. 1 . https://doi.org/10.1186/s13148-018-0512-1

Background High expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis and cancer progression. Major epigenetic modifications in both DNA and histo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe6fa23dffe872da856e1bbbc190d17
http://link.springer.com/article/10.1186/s13148-018-0512-1

Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment

Autor: Haytham El Salhat, Salman M Toor, Azharuddin Sajid Syed Khaja, Eyad Elkord, Bassam R. Ali, Issam Faour, Navid Ul Haq

Publikováno v: Oncotarget
Khaja, A S S, Toor, S M, El Salhat, H, Faour, I, ul Haq, N, Ali, B R & Elkord, E 2017, ' Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment ', Oncotarget, vol. 8, no. 20, pp. 33159-33171 . https://doi.org/10.18632/oncotarget.16565

// Azharuddin Sajid Syed Khaja 1, 2, * , Salman M. Toor 1, 2, * , Haytham El Salhat 3, 4 , Issam Faour 4 , Navid Ul Haq 5 , Bassam R. Ali 6 , Eyad Elkord 1, 2, 7 1 Cancer Research Center, Qatar Biomedical Research Institute, College of Science and En

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39de4ca634a2e0db48b118b3378b107a
https://pubmed.ncbi.nlm.nih.gov/28388539

Increased levels of circulating and tumor-infiltrating granulocytic myeloid cells in colorectal cancer patients

Autor: Haytham El Salhat, Azharuddin Sajid Syed Khaja, Jihad Kanbar, Salman M Toor, Omar Bekdache, Mohammed Jaloudi, Eyad Elkord

Publikováno v: Frontiers in Immunology, Vol 7 (2016)
Toor, S M, Khaja, A S S, El Salhat, H, Bekdache, O, Kanbar, J, Jaloudi, M & Elkord, E 2016, ' Increased levels of circulating and tumor-infiltrating granulocytic myeloid cells in colorectal cancer patients ', Frontiers in Immunology, vol. 7, no. DEC, 560 . https://doi.org/10.3389/fimmu.2016.00560
Frontiers in Immunology

Increased levels of myeloid cells, especially myeloid-derived suppressor cells (MDSCs), have been reported to correlate with bad prognosis and reduced survival in cancer patients. However, limited data are available on their conclusive phenotypes and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b15ae2737b2523abcfe400c9a22edd
http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00560/full

An Overview of Cancer Care in Societies in Transition: Global Perspectives—UAE Experience

Autor: Mohammed Jaloudi, David. M. James, Jihad Kanbar, Haytham El-Salhat

Publikováno v: Cancer Care in Countries and Societies in Transition ISBN: 9783319229119

Cancer is not a modern disease but has clearly existed for many centuries. It is however a more common phenomenon nowadays than previously due to the increase of the world’s population and the relatively advanced age to which people now live, since

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89a057bc932a71fba745b6a0e107e8f5
https://doi.org/10.1007/978-3-319-22912-6_19

Giant Cell Tumor: Rare Cases -- Surgery vs. Medical Treatment.

Autor: Mohammed, Jaloudi, Pawan, Kumar, Rasha, Elzain, Jihad, Kanbar, Haytham, El-Salhat

Publikováno v: Pan Arab Journal of Oncology; Mar2014, Vol. 7 Issue 1, p12-15, 4p