Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hays Watson, A."'
Autor:
Laura de Boni, Amber Wallis, Aurelia Hays Watson, Alejandro Ruiz-Riquelme, Louise-Ann Leyland, Thomas Bourinaris, Naomi Hannaway, Ullrich Wüllner, Oliver Peters, Josef Priller, Björn H Falkenburger, Jens Wiltfang, Mathias Bähr, Inga Zerr, Katharina Bürger, Robert Perneczky, Stefan Teipel, Matthias Löhle, Wiebke Hermann, Björn-Hendrik Schott, Kathrin Brockmann, Annika Spottke, Katrin Haustein, Peter Breuer, Henry Houlden, Rimona S Weil, Tim Bartels
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1657-1674 (2024)
Abstract Synucleinopathies such as Parkinson’s disease (PD) are defined by the accumulation and aggregation of the α-synuclein protein in neurons, glia and other tissues. We have previously shown that destabilization of α-synuclein tetramers is a
Externí odkaz:
https://doaj.org/article/236805c429ea4d8aa5198401625295ba
Autor:
Nagendran Ramalingam, Shan-Xue Jin, Tim E. Moors, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P. Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David Sulzer, Eugene V. Mosharov, Weisheng V. Chen, Shaomin Li, Dennis J. Selkoe, Ulf Dettmer
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract In Parkinson’s disease and other synucleinopathies, the elevation of α-synuclein phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the physiological role for pS129 has remained undefined. Here we use mult
Externí odkaz:
https://doaj.org/article/d183b6fc70b54d8f9e89896f83034181
Akademický článek
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Autor:
Colin Anthony Lee, Winsor Hays Watson
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The sea slug Melibe leonina is an excellent model system for the study of the neural basis of satiation, and previous studies have demonstrated that stomach distention attenuates feeding. Here we expanded on this work by examining the pathway communi
Externí odkaz:
https://doaj.org/article/b00f2d244c794871a082922e7322c224
Autor:
Laura de Boni, Aurelia Hays Watson, Ludovica Zaccagnini, Amber Wallis, Kristina Zhelcheska, Nora Kim, John Sanderson, Haiyang Jiang, Elodie Martin, Adam Cantlon, Matteo Rovere, Lei Liu, Marc Sylvester, Tammaryn Lashley, Ulf Dettmer, Zane Jaunmuktane, Tim Bartels
Publikováno v:
Acta neuropathologica. 143(4)
The protein α-synuclein, a key player in Parkinson’s disease (PD) and other synucleinopathies, exists in different physiological conformations: cytosolic unfolded aggregation-prone monomers and helical aggregation-resistant multimers. It has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87318712d2733bb6280562c1968fc645
https://pubmed.ncbi.nlm.nih.gov/35141810
https://pubmed.ncbi.nlm.nih.gov/35141810
Publikováno v:
Frontiers in Physiology; 11/23/2022, Vol. 13, p01-11, 11p
Autor:
Lei Liu, Ulf Dettmer, Aurelia Hays Watson, Ludovica Zaccagnini, Zane Jaunmuktane, Nora C. Kim, Marc Sylvester, Adam Cantlon, Elodie Martin, Matteo Rovere, Haiyang Jiang, John B. Sanderson, Tim Bartels, Tammaryn Lashley, Laura de Boni
The α-synuclein protein (αS) is the major constituent of pathological neuronal inclusions both in Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB) with differential brain region-specific pathology patterns and clinical presentations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b087e04b4e0d12bca83b7ae2209e395a
https://doi.org/10.21203/rs.3.rs-294515/v1
https://doi.org/10.21203/rs.3.rs-294515/v1
Autor:
Sanderson, J.B., De, S., Jiang, H., Rovere, M., Jin, M., Zaccagnini, L., Hays Watson, A., De Boni, L., Lagomarsino, V.N., Young-Pearse, T.L., Liu, X., Pochapsky, T.C., Hyman, B.T., Dickson, D.W., Klenerman, D., Selkoe, D.J., Bartels, T.
Publikováno v:
Brain Communications
Since researchers identified α-synuclein as the principal component of Lewy bodies and Lewy neurites, studies have suggested that it plays a causative role in the pathogenesis of dementia with Lewy bodies and other ‘synucleinopathies’. While α-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::bbd4e3ba11e4f4d85b48c45791ad4fb3
Autor:
Thomas C. Pochapsky, Tracy L. Young-Pearse, Bradley T. Hyman, John B. Sanderson, Laura de Boni, Dennis J. Selkoe, Xinyue Liu, Suman De, Valentina N. Lagomarsino, Haiyang Jiang, Ming Jin, Aurelia Hays Watson, Dennis W. Dickson, David Klenerman, Tim Bartels, Ludovica Zaccagnini, Matteo Rovere
Publikováno v:
Brain Communications
Since researchers identified α-synuclein as the principal component of Lewy bodies and Lewy neurites, studies have suggested that it plays a causative role in the pathogenesis of dementia with Lewy bodies and other ‘synucleinopathies’. While α-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d562ee52853d3022517306af113f45
https://doi.org/10.1093/braincomms/fcaa010
https://doi.org/10.1093/braincomms/fcaa010
Autor:
Sanderson, John B, De, Suman, Jiang, Haiyang, Rovere, Matteo, Jin, Ming, Zaccagnini, Ludovica, Hays Watson, Aurelia, De Boni, Laura, Lagomarsino, Valentina N, Young-Pearse, Tracy L, Liu, Xinyue, Pochapsky, Thomas C, Hyman, Bradley T, Dickson, Dennis W, Klenerman, David, Selkoe, Dennis J, Bartels, Tim
Since researchers identified α-synuclein as the principal component of Lewy bodies and Lewy neurites, studies have suggested that it plays a causative role in the pathogenesis of dementia with Lewy bodies and other 'synucleinopathies'. While α-synu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::440cb8052565e4bf749a476e660e9339