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Akademický článek

Incorporation of genetic model parameters for cost-effective designs of genetic association studies using DNA pooling

Autor: Mendell Nancy R, Haynes Chad, Finch Stephen J, Ji Fei, Gordon Derek

Publikováno v: BMC Genomics, Vol 8, Iss 1, p 238 (2007)

Abstract Background Studies of association methods using DNA pooling of single nucleotide polymorphisms (SNPs) have focused primarily on the effects of "machine-error", number of replicates, and the size of the pool. We use the non-centrality paramet

Externí odkaz: https://doaj.org/article/acdc20c33abc40a28ecf7db0acb9a185

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Akademický článek

LRTae: improving statistical power for genetic association with case/control data when phenotype and/or genotype misclassification errors are present

Autor: Stone Millicent, Haynes Chad, Barral Sandra, Gordon Derek

Publikováno v: BMC Genetics, Vol 7, Iss 1, p 24 (2006)

Abstract Background In the field of statistical genetics, phenotype and genotype misclassification errors can substantially reduce power to detect association with genetic case/control studies. Misclassification also can bias population frequency par

Externí odkaz: https://doaj.org/article/ef7d3748c3f5446284eff83e00757d81

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Akademický článek

Power and sample size calculations in the presence of phenotype errors for case/control genetic association studies

Autor: Finch Stephen J, Levenstien Mark A, Haynes Chad, Edwards Brian J, Gordon Derek

Publikováno v: BMC Genetics, Vol 6, Iss 1, p 18 (2005)

Abstract Background Phenotype error causes reduction in power to detect genetic association. We present a quantification of phenotype error, also known as diagnostic error, on power and sample size calculations for case-control genetic association st

Externí odkaz: https://doaj.org/article/223003ae2ce749c494a8196ef372ddfe

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