Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hayley T. Nicholls"'
Autor:
Yue Li, Norihiro Imai, Hayley T. Nicholls, Blaine R. Roberts, Samaksh Goyal, Tibor I. Krisko, Lay-Hong Ang, Matthew C. Tillman, Anne M. Roberts, Mahnoor Baqai, Eric A. Ortlund, David E. Cohen, Susan J. Hagen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Cold exposure activates thermogenesis and fatty acid oxidation in brown fat, a process suppressed by Them1. Here, the authors show that cold induces Them1 phosphorylation and loss of puncta that suppress fatty acid use, leading to a diffuse localizat
Externí odkaz:
https://doaj.org/article/e474110267a740bcbae71a2b1885f9cd
Autor:
Norihiro Imai, Yingxia Li, Eric A. Ortlund, David E. Cohen, Hayley T. Nicholls, Michele Alves-Bezerra, Anna A. Ivanova
Publikováno v:
Hepatology
BACKGROUND & AIMS: Thioesterase superfamily member 2 (Them2) is highly expressed in liver and oxidative tissues, where it hydrolyzes long chain fatty acyl-CoA esters to free fatty acids and CoA. Although mice globally lacking Them2 (Them2(−/−)) a
Autor:
Zaid Tafesh, Arun Jesudian, Tasha B. Kulai, Robert E. Schwartz, Nicholas Russo, Hirsh D. Trivedi, Robert S. Brown, Omar Y. Mousa, Enis Kostallari, Hayley T. Nicholls, Nicole T. Shen, Harmeet Malhi, Joseph F. Pisa, Petra Hirsova, Vikas Gupta, Brett E. Fortune, Xu Xu, Daryl T.-Y. Lau
Publikováno v:
Hepatology. 69:927-930
Autor:
Nicholas Russo, Arun Jesudian, Nicole T. Shen, Robert S. Brown, Akiko Sugiyama, Hayley T. Nicholls, Joseph F. Pisa, Tibor I. Krisko, Russell Rosenblatt, Zaid H. Tafesh, Brett E. Fortune, Omar Mousa, Harmeet Malhi, Robert E. Schwartz, Vikas Gupta, Tasha B. Kulai
Publikováno v:
Hepatology. 69:1-4
Autor:
Stefan Tholen, Roma Patel, Agnieszka Agas, Kyle M. Kovary, Atefeh Rabiee, Hayley T. Nicholls, Ewa Bielczyk-Maczyńska, Wenting Yang, Fredric B. Kraemer, Mary N. Teruel
Publikováno v:
Cell Rep
Disruption of circadian glucocorticoid oscillations in Cushing's disease and chronic stress results in obesity and adipocyte hypertrophy, which is believed to be a main source of the harmful effects of obesity. Here, we recapitulate stress due to jet
Autor:
Anna A. Ivanova, Michele Alves-Bezerra, Hayley T. Nicholls, David E. Cohen, Yulin Li, Norihiro Imai, Eric A. Ortlund
Thioesterase superfamily member 2 (Them2) is highly expressed in oxidative tissues where it hydrolyzes long chain fatty acyl-CoA esters to free fatty acids and CoA. Although mice globally lacking Them2 (Them2-/-) are protected against diet-induced ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10f52b91ffa0ce41d8ada682059aeaeb
https://doi.org/10.1101/2021.04.21.440732
https://doi.org/10.1101/2021.04.21.440732
Autor:
Samaksh Goyal, Hayley T. Nicholls, Yue Li, Eric A. Ortlund, Tibor Krisko, Blaine R. Roberts, Norihiro Imai, Susan J. Hagen, David E. Cohen, Lay-Hong Ang, Matthew C. Tillman, Mahnoor Baqai, Anne M. Roberts
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
In brown adipose tissue, thermogenesis is suppressed by thioesterase superfamily member 1 (Them1), a long chain fatty acyl-CoA thioesterase. Them1 is highly upregulated by cold ambient temperature, where it reduces fatty acid availability and limits
Autor:
Tibor Krisko, Matthew C. Tillman, Mahnoor Baqai, Li Y, Samaksh Goyal, Susan J. Hagen, David E. Cohen, Norihiro Imai, Eric A. Ortlund, Hayley T. Nicholls, Lay-Hong Ang
In brown adipose tissue, cold exposure promotes thermogenesis, in large part by increasing mitochondrial β-oxidation of lipid droplet-derived fatty acids. This process is suppressed by thioesterase superfamily member 1 (Them1), a long chain fatty ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f67e6f7c4970e320adfb92b15ec817
https://doi.org/10.1101/2020.02.18.954818
https://doi.org/10.1101/2020.02.18.954818
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 313:G50-G61
Mice fed a methionine- and choline-deficient (MCD) diet develop steatohepatitis that recapitulates key features of nonalcoholic steatohepatitis (NASH) in humans. Phosphatidylcholine is the most abundant phospholipid in the surfactant monolayer that c
Autor:
Norihiro Imai, Tibor I. Krisko, Zaid H. Tafesh, Catherine Lucero, Michele Alves‐Bezerra, Hayley T. Nicholls, Sandra Steensels, Baran A. Ersoy, Russell Rosenblatt, Robert E. Schwartz, Vikas Gupta, Zurabi Lominadze, Brett E. Fortune
Publikováno v:
Hepatology. 68:1665-1667