Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Hayley S McLoughlin"'
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204438 (2018)
Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disorder caused by a polyglutamine-encoding CAG repeat expansion in the ATXN3 gene which encodes the deubiquitinating enzyme, ATXN3. Several mechanisms have been propose
Externí odkaz:
https://doaj.org/article/dbb46c065ea745759fab0c7153328a07
Autor:
Ivan Tkáč, Tiankai Xie, Nitya Shah, Sarah Larson, Janet M. Dubinsky, Rocio Gomez-Pastor, Hayley S. McLoughlin, Harry T. Orr, Lynn E. Eberly, Gülin Öz
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
ObjectiveTo determine sex differences in the neurochemical concentrations measured by in vivo proton magnetic resonance spectroscopy (1H MRS) of healthy mice on a genetic background commonly used for neurodegenerative disease models.Methods1H MRS dat
Externí odkaz:
https://doaj.org/article/b8f8c098ce7d462c978a9332d847edce
Autor:
David Mengel, Isabel G. Wellik, Kristen H. Schuster, Sabrina I. Jarrah, Madeleine Wacker, Naila S. Ashraf, Gülin Öz, Matthis Synofzik, Maria do Carmo Costa, Hayley S. McLoughlin
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/e92c614177774bf6a45cbca2558c9111
Autor:
Kristen H. Schuster, Danielle M. DiFranco, Alexandra F. Putka, Juan P. Mato, Sabrina I. Jarrah, Nicholas R. Stec, Vikram O. Sundararajan, Hayley S. McLoughlin
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disease caused by a CAG repeat expansion in the ATXN3 gene. Though the ATXN3 protein is expressed ubiquitously throughout the CNS, regional pathology in SCA3 patients is observed within sele
Externí odkaz:
https://doaj.org/article/6737c8cc4b5e49f8befd2d154d84aac9
Publikováno v:
Cells, Vol 12, Iss 4, p 601 (2023)
Human studies, in combination with animal and cellular models, support glial cells as both major contributors to neurodegenerative diseases and promising therapeutic targets. Among glial cells, oligodendrocytes and Schwann cells are the myelinating g
Externí odkaz:
https://doaj.org/article/5f245f6cf9ad4cd9ae3dafd71e480c2c
Autor:
Mark L. Schultz, Maria V. Fawaz, Ruth D. Azaria, Todd C. Hollon, Elaine A. Liu, Thaddeus J. Kunkel, Troy A. Halseth, Kelsey L. Krus, Ran Ming, Emily E. Morin, Hayley S. McLoughlin, David D. Bushart, Henry L. Paulson, Vikram G. Shakkottai, Daniel A. Orringer, Anna S. Schwendeman, Andrew P. Lieberman
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-18 (2019)
Abstract Background Niemann–Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therapeutics for this diso
Externí odkaz:
https://doaj.org/article/e83baffb0e3847bbafc88e3c4bd749f6
Publikováno v:
Cells, Vol 11, Iss 16, p 2615 (2022)
Emerging evidence has implicated non-neuronal cells, particularly oligodendrocytes, in the pathophysiology of many neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disea
Externí odkaz:
https://doaj.org/article/122c89bea9924dfda1ce58cefe476693
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Tandem repeat diseases include the neurodegenerative disorders known as polyglutamine (polyQ) diseases, caused by CAG repeat expansions in the coding regions of the respective disease genes. The nine known polyQ disease include Huntington’s disease
Externí odkaz:
https://doaj.org/article/58bc2c3644324f619dfe59643abe78e2
Autor:
Lauren R. Moore, Gautam Rajpal, Ian T. Dillingham, Maya Qutob, Kate G. Blumenstein, Danielle Gattis, Gene Hung, Holly B. Kordasiewicz, Henry L. Paulson, Hayley S. McLoughlin
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 200-210 (2017)
The most common dominantly inherited ataxia, spinocerebellar ataxia type 3 (SCA3), is an incurable neurodegenerative disorder caused by a CAG repeat expansion in the ATXN3 gene that encodes an abnormally long polyglutamine tract in the disease protei
Externí odkaz:
https://doaj.org/article/7762a890132a4bfab35fef92ccc749e8
Autor:
Hayley S. McLoughlin, Katherine Gundry, Orion Rainwater, Kristen H. Schuster, Isabel G. Wellik, Annie J. Zalon, Michael A. Benneyworth, Lynn E. Eberly, Gülin Öz
Publikováno v:
Annals of Neurology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1063716b1d3b4df40777f90d6cc3b14
https://doi.org/10.1002/ana.26713
https://doi.org/10.1002/ana.26713