Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hayley R. Moore"'
Age is a significant risk factor for the development of cancer. Both age-dependent accumulation of cell autonomous mutations within preneoplastic cells and increases in senescent stromal cells within the tumor microenvironment are thought to collabor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ee4900490e8e9149f297dde67815d5
Autor:
Marko Vujanovic, Ralph Zellweger, Saravanabhavan Thangavel, Alessandro Vindigni, Cosimo Pinto, Eu Han Lee, Hayley R. Moore, Eric A. Hendrickson, Shivasankari Gomathinayagam, Maryna Levikova, Matteo Berti, Sheila A. Stewart, Massimo Lopes, Petr Cejka
Publikováno v:
The Journal of Cell Biology
J Cell Biol
The Journal of cell biology
J Cell Biol
The Journal of cell biology
Following prolonged genotoxic stress, DNA2 and WRN functionally interact to degrade reversed replication forks and promote replication restart, thereby preventing aberrant processing of unresolved replication intermediates
Accurate processing of
Accurate processing of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed34acc26314f06241b22adbd66cacf8
http://europepmc.org/articles/PMC4347643
http://europepmc.org/articles/PMC4347643
Autor:
Sheila A. Stewart, Mai Nguyen, Helen Piwnica-Worms, Yuchi Honaker, Elise Alspach, Daniel C. Teasley, Shankar Parajuli, Abhishek Saharia, Ying Jie Lock, Hayley R. Moore
Publikováno v:
The Journal of biological chemistry. 290(24)
The existence of redundant replication and repair systems that ensure genome stability underscores the importance of faithful DNA replication. Nowhere is this complexity more evident than in challenging DNA templates, including highly repetitive or t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5c8a8ec5c397a96d4e017eca15c25c
https://pubmed.ncbi.nlm.nih.gov/25922071
https://pubmed.ncbi.nlm.nih.gov/25922071
Autor:
Yuchi Honaker, Raymond J. Monnat, Julien P. Duxin, Judith L. Campbell, Helen Piwnica-Worms, Sheila A. Stewart, Hayley R. Moore, Kenneth K. Karanja, Julia M. Sidorova, Benjamin Dao
Publikováno v:
The Journal of biological chemistry. 287(26)
Dna2 is an essential helicase/nuclease that is postulated to cleave long DNA flaps that escape FEN1 activity during Okazaki fragment (OF) maturation in yeast. We previously demonstrated that the human Dna2 orthologue (hDna2) localizes to the nucleus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d074e5cb0004a7a6a1929d1ac96134c9
https://pubmed.ncbi.nlm.nih.gov/22570476
https://pubmed.ncbi.nlm.nih.gov/22570476
The stringent response is important for bacterial survival under stressful conditions, such as amino acid starvation, and is characterized by the accumulation of ppGpp and pppGpp. ObgE (CgtA, YhbZ) is an essential conserved GTPase in Escherichia coli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e0d7088e6f44b5ef43857a3d4e737c
https://europepmc.org/articles/PMC2771346/
https://europepmc.org/articles/PMC2771346/
Publikováno v:
Methods (San Diego, Calif.). 48(1)
We describe a method for synchronization of the cell cycle in the bacterium Escherichia coli. Treatment of asynchronous cultures with the amino acid analog, dl-serine hydroxamate, induces the stringent response, with concomitant arrest of DNA replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac5ea013db3c24634b084de75b27638
https://pubmed.ncbi.nlm.nih.gov/19245839
https://pubmed.ncbi.nlm.nih.gov/19245839