Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hayley M. Jones"'
Autor:
Timothy M. Chapman, David Whalley, Steven Howell, Simon A. Osborne, Hayley M. Jones, Claire Wallace, Munira Grainger, Rishi Kumar Nageshan, Debra L. Taylor, Keith H. Ansell, Ankit K. Rochani, Judith L. Green, Utpal Tatu, David A. Baker, Paul W. Bowyer, Robert W. Moon, Anthony A. Holder
Publikováno v:
Antimicrobial Agents and Chemotherapy
Imidazopyridazine compounds are potent, ATP-competitive inhibitors of calcium-dependent protein kinase 1 (CDPK1) and of Plasmodium falciparum parasite growth in vitro . Here, we show that these compounds can be divided into two classes depending on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57077ff8429b090c88236ed0844edda5
http://europepmc.org/articles/PMC4775997
http://europepmc.org/articles/PMC4775997
Autor:
David W. Melton, Douglas R. Houston, Preeti Bakrania, Martin A. Wear, Barbara Saxty, Ann Marie Ritchie, Steven Shave, Tim Chapman, Katy R. Astell, Puneet Khurana, Claire Wallace, Ewan M. McNeil, Malcolm D. Walkinshaw, Hayley M. Jones
Publikováno v:
McNeil, E M, Astell, K R, Ritchie, A-M, Shave, S, Houston, D R, Bakrania, P, Jones, H M, Khurana, P, Wallace, C, Chapman, T, Wear, M A, Walkinshaw, M D, Saxty, B & Melton, D W 2015, ' Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance ', DNA Repair, vol. 31, pp. 19-28 . https://doi.org/10.1016/j.dnarep.2015.04.002
ERCC1-XPF is a structure-specific endonuclease that is required for the repair of DNA lesions, generated by the widely used platinum-containing cancer chemotherapeutics such as cisplatin, through the Nucleotide Excision Repair and Interstrand Crossli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12993ce61849793f7a457e1790dd3fe
https://doi.org/10.1016/j.dnarep.2015.04.002
https://doi.org/10.1016/j.dnarep.2015.04.002
Autor:
Robert W. Moon, Barbara Clough, Nathalie Bouloc, Jonathan M. Large, Judith L. Green, Simon A. Osborne, David Whalley, Hayley M. Jones, Anthony A. Holder, Keith H. Ansell, Timothy M. Chapman, Kristian Birchall, Claire Wallace, Emmanuel C. Patin, Ela Smiljanic-Hurley, Alisdair Hearn, Debra L. Taylor
Publikováno v:
Antimicrobial Agents and Chemotherapy
PfCDPK1 is a Plasmodium falciparum calcium-dependent protein kinase, which has been identified as a potential target for novel antimalarial chemotherapeutics. In order to further investigate the role of PfCDPK1, we established a high-throughput in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21667e911f73d5150973d34df8ebab70
http://europepmc.org/articles/PMC4187893
http://europepmc.org/articles/PMC4187893
Autor:
Anthony A. Holder, Nathalie Bouloc, Keith H. Ansell, Debra L. Taylor, Timothy M. Chapman, Kristian Birchall, Barbara Clough, Simon A. Osborne, Hayley M. Jones, Claire Wallace, Judith L. Green
Publikováno v:
Journal of Medicinal Chemistry; Vol 57
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
A structure-guided design approach using a homology model of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) was used to improve the potency of a series of imidazopyridazine inhibitors as potential antimalarial agents. This resulte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a15911976c779eab1898e83b25e14e
Autor:
Anthony A. Holder, Keith H. Ansell, Judith L. Green, Simon A. Osborne, Jonathan M. Large, Ela Smiljanic-Hurley, Barbara Clough, Debra L. Taylor, Hayley M. Jones
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters; Vol 23
Bioorganic & Medicinal Chemistry Letters; Vol 23
Graphical abstract
The structural diversity and SAR in a series of imidazopyridazine inhibitors of Plasmodium falciparum calcium dependent protein kinase 1 (PfCDPK1) has been explored and extended. The opportunity to further improve key ADME par
The structural diversity and SAR in a series of imidazopyridazine inhibitors of Plasmodium falciparum calcium dependent protein kinase 1 (PfCDPK1) has been explored and extended. The opportunity to further improve key ADME par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5220fcc8c989ed17ee875656902bca
https://doi.org/10.1016/j.bmcl.2013.08.010
https://doi.org/10.1016/j.bmcl.2013.08.010
Autor:
Hayley M. Jones, Keith H. Ansell, Timothy M. Chapman, Nathalie Bouloc, Anthony A. Holder, Kristian Birchall, Judith L. Green, Barbara Clough, Claire Wallace, Jonathan M. Large, Simon A. Osborne, Debra L. Taylor
Publikováno v:
Bioorganic & Medicinal Chemistry Letters; Vol 23
Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
A series of imidazopyridazines which are potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) was identified from a high-throughput screen against the isolated enzyme. Subsequent exploration
A series of imidazopyridazines which are potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) was identified from a high-throughput screen against the isolated enzyme. Subsequent exploration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443babb4f37d0faf1ee4a7b3d6ad102c
Autor:
Keith H. Ansell, Debra L. Taylor, Anthony A. Holder, Simon A. Osborne, Barbara Clough, Ela Smiljanic-Hurley, Hayley M. Jones, Jonathan M. Large, Judith L. Green
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Table 4 appeared incorrectly. The corrected table appears below. Table 4 Selected cyanophenyl pyrazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888549d58143c2cbafa46f564e787b7a