Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Hayley J. Newton"'
Autor:
Claudia Simm, Harshini Weerasinghe, David R. Thomas, Paul F. Harrison, Hayley J. Newton, Traude H. Beilharz, Ana Traven
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Fungal infections are a global threat, but treatments are limited due to a paucity in antifungal drug targets and the emergence of drug-resistant fungi such as Candida auris. Metabolic adaptations enable microbial growth in nutrient-scarce h
Externí odkaz:
https://doaj.org/article/172355a0ddb54a15b437ef56414c2174
Autor:
Thao Thanh Tran, Carmen D. Mathmann, Marcela Gatica-Andrades, Rachel F. Rollo, Melanie Oelker, Johanna K. Ljungberg, Tam T. K. Nguyen, Alina Zamoshnikova, Lalith K. Kummari, Orry J. K. Wyer, Katharine M. Irvine, Javier Melo-Bolívar, Annette Gross, Darren Brown, Jeffrey Y. W. Mak, David P. Fairlie, Karl A. Hansford, Matthew A. Cooper, Rabina Giri, Veronika Schreiber, Shannon R. Joseph, Fiona Simpson, Timothy C. Barnett, Jörgen Johansson, Wendy Dankers, James Harris, Timothy J. Wells, Ronan Kapetanovic, Matthew J. Sweet, Eleanor A. Latomanski, Hayley J. Newton, Romain J. R. Guérillot, Abderrahman Hachani, Timothy P. Stinear, Sze Ying Ong, Yogeswari Chandran, Elizabeth L. Hartland, Bostjan Kobe, Jennifer L. Stow, A. Elisabeth Sauer-Eriksson, Jakob Begun, Jessica C. Kling, Antje Blumenthal
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1 (2022)
A hallmark of Listeria (L.) monocytogenes pathogenesis is bacterial escape from maturing entry vacuoles, which is required for rapid bacterial replication in the host cell cytoplasm and cell-to-cell spread. The bacterial transcriptional activator Prf
Externí odkaz:
https://doaj.org/article/66dd0ab76b8e4e24a1aee04a59d0cdfa
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Autophagy is a fundamental and highly conserved eukaryotic process, responsible for maintaining cellular homeostasis and releasing nutrients during times of starvation. An increasingly important function of autophagy is its role in the cell autonomou
Externí odkaz:
https://doaj.org/article/e56af28c13f64520b692bc51c0e9fb7b
Autor:
Cameron C. Oppy, Leila Jebeli, Miku Kuba, Clare V. Oates, Richard Strugnell, Laura E. Edgington-Mitchell, Miguel A. Valvano, Elizabeth L. Hartland, Hayley J. Newton, Nichollas E. Scott
Publikováno v:
mSphere, Vol 4, Iss 6 (2019)
ABSTRACT O-linked protein glycosylation is a conserved feature of the Burkholderia genus. The addition of the trisaccharide β-Gal-(1,3)-α-GalNAc-(1,3)-β-GalNAc to membrane exported proteins in Burkholderia cenocepacia is required for bacterial fit
Externí odkaz:
https://doaj.org/article/420dcd1484ec4328b4745ae031fe35ca
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Externí odkaz:
https://doaj.org/article/54b6db5fed934684978ea141159bb30b
Autor:
Lara J. Kohler, Shawna C. O. Reed, Shireen A. Sarraf, David D. Arteaga, Hayley J. Newton, Craig R. Roy
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
Externí odkaz:
https://doaj.org/article/4de5bb7ff5534e40982cf99a07df7c3c
Autor:
Lara J. Kohler, Shawna R. Reed, Shireen A. Sarraf, David D. Arteaga, Hayley J. Newton, Craig R. Roy
Publikováno v:
mBio, Vol 7, Iss 4 (2016)
ABSTRACT Coxiella burnetii replicates in an acidified lysosome-derived vacuole. Biogenesis of the Coxiella-containing vacuole (CCV) requires bacterial effector proteins delivered into host cells by the Dot/Icm secretion system. Genetic and cell biolo
Externí odkaz:
https://doaj.org/article/8bb47c6794e64fadac548e48b9bdf846
Autor:
Hayley J. Newton, Joan Sloan, Dieter M. Bulach, Torsten Seemann, Cody C. Allison, Marija Tauschek, Roy M. Robins-Browne, James C. Paton, Thomas S. Whittam, Adrienne W. Paton, Elizabeth L. Hartland
Publikováno v:
Emerging Infectious Diseases, Vol 15, Iss 3, Pp 372-380 (2009)
Most Shiga toxin–producing Escherichia coli (STEC) infections that are associated with severe sequelae such as hemolytic uremic syndrome (HUS) are caused by attaching and effacing pathogens that carry the locus of enterocyte effacement (LEE). Howev
Externí odkaz:
https://doaj.org/article/08c2608dd73541309c6afbc35198f504
Publikováno v:
mBio, Vol 4, Iss 1 (2013)
ABSTRACT Coxiella burnetii is an intracellular pathogen that replicates within a lysosome-like vacuole. A Dot/Icm type IVB secretion system is used by C. burnetii to translocate effector proteins into the host cytosol that likely modulate host factor
Externí odkaz:
https://doaj.org/article/a179843a94dc4a3b9faff6d6e6760f39
Autor:
Hayley J. Newton, Craig R. Roy
Publikováno v:
mBio, Vol 2, Iss 5 (2011)
ABSTRACT Understanding the molecular pathogenesis of Coxiella burnetii, the causative agent of human Q fever, has historically been hindered by the technical difficulties of genetically manipulating obligate intracellular bacteria. The recent develop
Externí odkaz:
https://doaj.org/article/327d4ef623ec45a69360c9bd3f7ac2a6