Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hayley G. Evans"'
Autor:
Gurman Kaur, Caroline B. M. Porter, Orr Ashenberg, Jack Lee, Samantha J. Riesenfeld, Matan Hofree, Maria Aggelakopoulou, Ayshwarya Subramanian, Subita Balaram Kuttikkatte, Kathrine E. Attfield, Christiane A. E. Desel, Jessica L. Davies, Hayley G. Evans, Inbal Avraham-Davidi, Lan T. Nguyen, Danielle A. Dionne, Anna E. Neumann, Lise Torp Jensen, Thomas R. Barber, Elizabeth Soilleux, Mary Carrington, Gil McVean, Orit Rozenblatt-Rosen, Aviv Regev, Lars Fugger
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Natural Killer cells regulate foetal growth. Here the authors use a humanized transgenic mouse to demonstrate that specific HLA-C KIR2DL interactions promote changes in maternal and foetal cell transcriptomes, resulting in modifications to placental
Externí odkaz:
https://doaj.org/article/2d63981d766b447aaf8cd3b6178c97fc
Autor:
Eva Brencicova, Ann L Jagger, Hayley G Evans, Mirella Georgouli, Alex Laios, Steve Attard Montalto, Gautam Mehra, Jo Spencer, Ahmed A Ahmed, Shanti Raju-Kankipati, Leonie S Taams, Sandra S Diebold
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175712 (2017)
Dendritic cells (DC) have the potential to instigate a tumour-specific immune response, but their ability to prime naïve lymphocytes depends on their activation status. Thus, for tumour immunotherapy to be effective, the provision of appropriate DC
Externí odkaz:
https://doaj.org/article/670ae64c156149a6bfc812b6c2881e14
Autor:
Kathrine E. Attfield, Elizabeth J. Soilleux, Orit Rozenblatt-Rosen, Lise T. Jensen, Lars Fugger, Lan T. Nguyen, Matan Hofree, Aggelakopoulou M, Aviv Regev, Lee J, Anna Neumann, Thomas R Barber, Gil McVean, Davies Jl, Kaur G, Porter Cbm, Danielle Dionne, Subita Balaram Kuttikkatte, Orr Ashenberg, Mary Carrington, Hayley G. Evans, Samantha J. Riesenfeld, Desel Cae, Ayshwarya Subramanian, Inbal Avraham-Davidi
Intrauterine growth restriction (IUGR) of fetuses affects 5-10% of pregnancies and is associated with perinatal morbidity, mortality and long-term health issues. Understanding genetic predisposition to IUGR is challenging, owing to extensive gene pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd74f84be5053402b6acedf26e47f594
https://doi.org/10.1101/2021.03.26.437292
https://doi.org/10.1101/2021.03.26.437292
Autor:
Charlotte Schubert, Jan Broder Engler, Anne Willing, Gurman Kaur, Hayley G. Evans, Manuel A. Friese, Lars Fugger, Max Kaufmann, Nina Kursawe, Kathrine E. Attfield, Anna-Lena Schaupp
Publikováno v:
Med (New York, N.y.)
Summary Background Multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS), can be suppressed in its early stages but eventually becomes clinically progressive and unresponsive to therapy. Here, we investigate whether the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406ca4bee8ba3d0f55ea1a94c2b10c3a
https://ora.ox.ac.uk/objects/uuid:abc6f869-7ed5-40d8-99be-caf31fc05f14
https://ora.ox.ac.uk/objects/uuid:abc6f869-7ed5-40d8-99be-caf31fc05f14
Autor:
Jørgen Frøkiær, Christiane Desel, Britta Brügger, Paul M. Matthews, Lise T. Jensen, Soren L. Faergeman, Calliope A. Dendrou, Annette Bang Oturai, Hayley G. Evans, Christian Lüchtenborg, Mette Sommerlund, Subita Balaram Kuttikkatte, Lars Fugger, Manuel A. Friese, Kathrine E. Attfield
Publikováno v:
Cell Death & Disease
Faergeman, S L, Evans, H, Attfield, K E, Desel, C, Kuttikkatte, S B, Sommerlund, M, Jensen, L T, Frokiaer, J, Friese, M A, Matthews, P M, Luchtenborg, C, Brügger, B, Oturai, A B, Dendrou, C A & Fugger, L 2020, ' A novel neurodegenerative spectrum disorder in patients with MLKL deficiency ', Cell Death and Disease, vol. 11, no. 5, 303 . https://doi.org/10.1038/s41419-020-2494-0
Faergeman, S L, Evans, H, Attfield, K E, Desel, C, Kuttikkatte, S B, Sommerlund, M, Jensen, L T, Frokiaer, J, Friese, M A, Matthews, P M, Luchtenborg, C, Brügger, B, Oturai, A B, Dendrou, C A & Fugger, L 2020, ' A novel neurodegenerative spectrum disorder in patients with MLKL deficiency ', Cell Death and Disease, vol. 11, 303 . https://doi.org/10.1038/s41419-020-2494-0
Cell Death and Disease, Vol 11, Iss 5, Pp 1-13 (2020)
Faergeman, S L, Evans, H, Attfield, K E, Desel, C, Kuttikkatte, S B, Sommerlund, M, Jensen, L T, Frokiaer, J, Friese, M A, Matthews, P M, Luchtenborg, C, Brügger, B, Oturai, A B, Dendrou, C A & Fugger, L 2020, ' A novel neurodegenerative spectrum disorder in patients with MLKL deficiency ', Cell Death and Disease, vol. 11, no. 5, 303 . https://doi.org/10.1038/s41419-020-2494-0
Faergeman, S L, Evans, H, Attfield, K E, Desel, C, Kuttikkatte, S B, Sommerlund, M, Jensen, L T, Frokiaer, J, Friese, M A, Matthews, P M, Luchtenborg, C, Brügger, B, Oturai, A B, Dendrou, C A & Fugger, L 2020, ' A novel neurodegenerative spectrum disorder in patients with MLKL deficiency ', Cell Death and Disease, vol. 11, 303 . https://doi.org/10.1038/s41419-020-2494-0
Cell Death and Disease, Vol 11, Iss 5, Pp 1-13 (2020)
Mixed lineage kinase domain-like (MLKL) is the main executor of necroptosis, an inflammatory form of programmed cell death. Necroptosis is implicated in combating infections, but also in contributing to numerous other clinical conditions, including c
Autor:
Nicola J Gullick, Hayley G Evans, Leigh D Church, David M Jayaraj, Andrew Filer, Bruce W Kirkham, Leonie S Taams
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12516 (2010)
Power Doppler ultrasound (PDUS) is increasingly used to assess synovitis in Rheumatoid Arthritis (RA). Prior studies have shown correlations between PDUS scores and vessel counts, but relationships with T cell immunopathology have not been described.
Externí odkaz:
https://doaj.org/article/8bf2fbbdb4d44f78b810f2395009b904
Autor:
Veerle Fleskens, Leonie S. Taams, Bina Menon, Megha Rajasekhar, Jens Gerwien, Gina J Walter, Hayley G. Evans, Klaus Stensgaard Frederiksen
Publikováno v:
Arthritis & Rheumatology. 68:103-116
Objective Conflicting evidence exists regarding the suppressive capacity of Treg cells in the peripheral blood (PB) of patients with rheumatoid arthritis (RA). The aim of this study was to determine whether Treg cells are intrinsically defective in R
Publikováno v:
Frontiers in Immunology
Roberts, C A, Durham, L E, Fleskens, V, Evans, H G & Taams, L S 2017, ' TNF blockade maintains an IL-10+ phenotype in human effector CD4+ and CD8+ T cells ', Frontiers in Immunology, vol. 8, 157 . https://doi.org/10.3389/fimmu.2017.00157
Roberts, C A, Durham, L E, Fleskens, V, Evans, H G & Taams, L S 2017, ' TNF blockade maintains an IL-10+ phenotype in human effector CD4+ and CD8+ T cells ', Frontiers in Immunology, vol. 8, 157 . https://doi.org/10.3389/fimmu.2017.00157
CD4+ and CD8+ effector T cell subpopulations can display regulatory potential characterized by expression of the prototypically anti-inflammatory cytokine IL-10. However, the underlying cellular mechanisms that regulate expression of IL-10 in differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2778afb1fae8acf276d98bc1f51a47
https://doi.org/10.3389/fimmu.2017.00157
https://doi.org/10.3389/fimmu.2017.00157
Autor:
Megha Rajasekhar, Leonie S. Taams, Nicola J. Gullick, Gina J Walter, Toby Garrood, Bruce Kirkham, Bina Menon, Hayley G. Evans
Publikováno v:
Arthritis & Rheumatology. 66:1272-1281
Psoriatic arthritis (PsA) is an inflammatory joint disease of unclear etiology that affects ∼10–30% of patients with the skin condition psoriasis (1). Although PsA, like rheumatoid arthritis (RA), can result in pain, loss of function, and damage
Autor:
Oliver A. Leach, Adam R. Johnson, Jane Cheeseman, Fredrik Karpe, Thomas R Barber, Gurman Kaur, Hayley G. Evans, Charles Eigenbrot, Adrian Cortes, Stephen Sawcer, Lars Fugger, Luke Jostins, Lydia Shipman, John Bell, Soren L. Faergeman, Calliope A. Dendrou, Kathrine E. Attfield, Christine Everett, Mark Ultsch, Alastair Compston, Gil McVean, Christiane Desel, Subita Balaram Kuttikkatte, Matt J. Neville
Publikováno v:
Dendrou, C A, Cortes, A, Shipman, L, Evans, H G, Attfield, K E, Jostins, L, Barber, T, Kaur, G, Kuttikkatte, S B, Leach, O A, Desel, C, Faergeman, S L, Cheeseman, J, Neville, M J, Sawcer, S, Compston, A, Johnson, A R, Everett, C, Bell, J I, Karpe, F, Ultsch, M, Eigenbrot, C, McVean, G & Fugger, L 2016, ' Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity ', Science Translational Medicine, vol. 8, no. 363, pp. 363ra149 . https://doi.org/10.1126/scitranslmed.aag1974
Thousands of genetic variants have been identified, which contribute to the development of complex diseases, but determining how to elucidate their biological consequences for translation into clinical benefit is challenging. Conflicting evidence reg