Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Hayley Callan"'
Autor:
John Farrell, Sophie L. Regan, Dominic P. Williams, Neil R. Kitteringham, Alvin J. L. Chia, Laura E. Randle, Abhishek Srivastava, Christopher E. Goldring, Andrew V. Stachulski, Dean J. Naisbitt, Daniel J. Antoine, Thomas A. Baillie, Martin S. Lennard, J. Luis Castrejon, Hayley Callan, B. Kevin Park, Deepak Dalvie, R. Scott Obach
Publikováno v:
Medicinal Research Reviews. 33:985-1080
The decline in approval of new drugs during the past decade has led to a close analysis of the drug discovery process. One of the main reasons for attrition is preclinical toxicity, frequently attributed to the generation of protein-reactive drug met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1217e6dd82cee0f0556c3901275f778b
https://doi.org/10.1002/med.21273
https://doi.org/10.1002/med.21273
Autor:
Rosalind E. Jenkins, Stephen E. Clarke, Hayley Callan, B. Kevin Park, James L. Maggs, Dean J. Naisbitt, Sidonie N. Lavergne
Publikováno v:
Chemical Research in Toxicology. 22:937-948
Sulfamethoxazole (SMX) induces immunoallergic reactions that are thought to be a result of intracellular protein haptenation by its nitroso metabolite (SMX-NO mass, 267 amu). SMX-NO reacts with protein thiols in vitro, but the conjugates have not bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d0fdb62f59811fada83b74a4192aaa
https://doi.org/10.1021/tx900034r
https://doi.org/10.1021/tx900034r
Autor:
Andrew V, Stachulski, Thomas A, Baillie, B Kevin, Park, R Scott, Obach, Deepak K, Dalvie, Dominic P, Williams, Abhishek, Srivastava, Sophie L, Regan, Daniel J, Antoine, Christopher E P, Goldring, Alvin J L, Chia, Neil R, Kitteringham, Laura E, Randle, Hayley, Callan, J Luis, Castrejon, John, Farrell, Dean J, Naisbitt, Martin S, Lennard
Publikováno v:
Medicinal research reviews. 33(5)
The decline in approval of new drugs during the past decade has led to a close analysis of the drug discovery process. One of the main reasons for attrition is preclinical toxicity, frequently attributed to the generation of protein-reactive drug met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d88108b8bcf52152a08943373b43a994
https://pubmed.ncbi.nlm.nih.gov/23090860
https://pubmed.ncbi.nlm.nih.gov/23090860
Antigen-presenting cells (APC) are thought to play an important role in the pathogenesis of drug-induced immune reactions. Various pathological factors can activate APC and therefore influence the immune equilibrium. It is interesting that several di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca0ed70ae277912bb06acd5734e1c91
https://europepmc.org/articles/PMC2775259/
https://europepmc.org/articles/PMC2775259/
