Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Hayley C. Affronti"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Understanding the epigenetic control of normal differentiation programs might yield principal information about critical regulatory states that are disturbed in cancer. We utilized the established non-malignant HPr1-AR prostate epithelial ce
Externí odkaz:
https://doaj.org/article/1c9873b8918b4954ad0cf088d4af5c1d
Autor:
Hayley C. Affronti, Aryn M. Rowsam, Anthony J. Pellerite, Spencer R. Rosario, Mark D. Long, Justine J. Jacobi, Anna Bianchi-Smiraglia, Christoph S. Boerlin, Bryan M. Gillard, Ellen Karasik, Barbara A. Foster, Michael Moser, John H. Wilton, Kristopher Attwood, Mikhail A. Nikiforov, Gissou Azabdaftari, Roberto Pili, James G. Phillips, Robert A. Casero, Dominic J. Smiraglia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Prostate cancer cells depend on MTAP, the rate-limiting enzyme involved in the methionine salvage pathway, to cope with increased polyamine biosynthesis. Here, the authors show that inducing upregulation of polyamine biosynthesis and targeting MTAP s
Externí odkaz:
https://doaj.org/article/e67ec780a1554759a4b84c3b9ee77ce5
Autor:
Mark D. Long, Justine J. Jacobi, Prashant K. Singh, Gerard Llimos, Sajad A. Wani, Aryn M. Rowsam, Spencer R. Rosario, Marlous Hoogstraat, Simon Linder, Jason Kirk, Hayley C. Affronti, Andries Bergman, Wilbert Zwart, Moray J. Campbell, Dominic J. Smiraglia
Publikováno v:
Cell Reports, Vol 37, Iss 11, Pp 110109- (2021)
Summary: This study addresses the roles of nuclear receptor corepressor 2 (NCOR2) in prostate cancer (PC) progression in response to androgen deprivation therapy (ADT). Reduced NCOR2 expression significantly associates with shorter disease-free survi
Externí odkaz:
https://doaj.org/article/4a042eabf97c4a9c95ff32cac4f01811
Autor:
Sully Fernandez, John M. Viola, AnnMarie Torres, Martina Wallace, Sophie Trefely, Steven Zhao, Hayley C. Affronti, Jivani M. Gengatharan, David A. Guertin, Nathaniel W. Snyder, Christian M. Metallo, Kathryn E. Wellen
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2772-2784.e6 (2019)
Summary: Sugars and refined carbohydrates are major components of the modern diet. ATP-citrate lyase (ACLY) is upregulated in adipocytes in response to carbohydrate consumption and generates acetyl-coenzyme A (CoA) for both lipid synthesis and acetyl
Externí odkaz:
https://doaj.org/article/b1e97b77b6bb47a5b16ec6174ac70f5c
Autor:
Dominic J. Smiraglia, Aryn M. Rowsam, Hayley C. Affronti, Mark D. Long, Justine J. Jacobi, Spencer R. Rosario
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209e5f4664386f07d9731bc83480db09
https://doi.org/10.1158/1541-7786.22528133.v1
https://doi.org/10.1158/1541-7786.22528133.v1
Autor:
Dominic J. Smiraglia, Aryn M. Rowsam, Hayley C. Affronti, Mark D. Long, Justine J. Jacobi, Spencer R. Rosario
Identifying and leveraging unique points of metabolic dysregulation in different disease settings is vital for safe and effective incorporation of metabolism-targeted therapies in the clinic. In addition, it has been shown identification of master me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e86c2f0515a6a5b4c9b30b029c96a03
https://doi.org/10.1158/1541-7786.c.6545624.v1
https://doi.org/10.1158/1541-7786.c.6545624.v1
Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Autor:
Dominic J. Smiraglia, Aryn M. Rowsam, Hayley C. Affronti, Mark D. Long, Justine J. Jacobi, Spencer R. Rosario
Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0107944951712238f608c0fc9069d4af
https://doi.org/10.1158/1541-7786.22528109.v1
https://doi.org/10.1158/1541-7786.22528109.v1
Autor:
Kathryn E. Wellen, Ben Z. Stanger, Nathaniel W. Snyder, Benjamin A. Garcia, Alessandro Gardini, Marco Trizzino, Yogev Sela, Shaun Egolf, Sharanya Sivanand, Hayley C. Affronti, Joshua L.D. Parris, Simone Sidoli, Kollin C. Schultz, Robert J. Norgard, Sydney L. Campbell, Steven Zhao, Sophie Trefely, Alessandro Carrer
Figures S1-S7 and Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224b8fe602dcdfae5be3cb3ac813063a
https://doi.org/10.1158/2159-8290.22532489.v1
https://doi.org/10.1158/2159-8290.22532489.v1
Publikováno v:
Annual review of cancer biology
Metabolic and epigenetic reprogramming are characteristics of cancer cells that, in many cases, are linked. Oncogenic signaling, diet, and tumor microenvironment each influence the availability of metabolites that are substrates or inhibitors of epig
Autor:
Julianna G. Supplee, Hayley C. Affronti, Richard Duan, Rebekah C. Brooks, Phuong Nguyen, Kollin Schultz, Ronen Marmorstein, Kathryn E. Wellen
Publikováno v:
Cancer Research. 83:3711-3711
Introduction: ATP-citrate lyase (ACLY) links carbohydrate and lipid metabolism as well as provides acetyl-CoA necessary for histone acetylation, linking cell nutrient status and epigenetic regulation. Several studies have shown that ACLY is upregulat