Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hayley Angove"'
Autor:
Yuya Ogata, Harumi Kanazawa, Macias Alba, Norikazu Ohtake, Allan E. Surgenor, Iichiro Takata, Hajime Takashima, Walmsley David, Kiyoko Fujita, Hayley Angove, Kunihiko Iwamoto, Masashi Mima, Hiroyuki Sugiyama, Fumihito Ushiyama, Junya Yamagishi, Yousuke Yamada, Alan P. Robertson, Kosuke Hitaka, Koichiro Nakano, Hayato Watanabe, Atsushi Okada, Yohei Matsuda, Roderick E. Hubbard, Nozomi Tanaka-Yamamoto, Toru Yamaguchi-Sasaki, Risa Kurimoto-Tsuruta, Lisa Baker, Akihiro Tanaka, R. Harris
Publikováno v:
Journal of medicinal chemistry. 63(23)
UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) is a zinc metalloenzyme that catalyzes the first committed step in the biosynthesis of Lipid A, an essential component of the cell envelope of Gram-negative bacteria. The most advanced, disclosed Lp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019ee8a95fea26f38a355f0054fb803d
https://pubmed.ncbi.nlm.nih.gov/33210531
https://pubmed.ncbi.nlm.nih.gov/33210531
Autor:
Wrona Wojciech, Deborah J. Davis, Hayley Angove, Christopher Thomas Brain, Alison Jo-Anne Woolford, Fan Yang, Kim Lewry, Hong Cheng, Steven Kovats, Chen Christine Hiu-Tung, Alice Loo, Mei Xu, Claudio Dagostin, Miles Congreve, David C. Rees, John William Giraldes, Yaping Wang, Young Shin Cho, Glyn Williams, Rachel McMenamin, Troy Smith, Junqing Shen, Rajiv Chopra, Ruth Feltell, Yipin Lu, Wiesia Maniara, Bharat Lagu, Steven Howard, Kristy Chung, Robert Cheng, Steven Douglas Hiscock, Sunkyu Kim, Luzzio Michael, Marc O'Reilly, Rajdeep Benning, Paul N. Mortenson
Publikováno v:
ACS Medicinal Chemistry Letters. 3:445-449
Herein, we describe the discovery of potent and highly selective inhibitors of both CDK4 and CDK6 via structure-guided optimization of a fragment-based screening hit. CDK6 X-ray crystallography and pharmacokinetic data steered efforts in identifying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246f4930f1dba54c810db018516d6ce6
https://doi.org/10.1021/ml200241a
https://doi.org/10.1021/ml200241a
Autor:
Joe Coyle, Tomoko Smyth, Jayne Curry, Nicola G. Wallis, David M. Cross, Ruth Feltell, Isobel Harada, Brent Graham, Matthias Reule, Brian Williams, Hayley Angove, Lynsey Fazal, John Lyons, Neil T. Thompson
Publikováno v:
Cancer Sci
A ubiquitously expressed chaperone, heat shock protein 90 (HSP90) is of considerable interest as an oncology target because tumor cells and oncogenic proteins are acutely dependent on its activity. AT13387 (2,4‐dihydroxy‐5‐isopropyl‐phenyl)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a999a2489c589885299826255d78ec3e
https://doi.org/10.1111/j.1349-7006.2011.02191.x
https://doi.org/10.1111/j.1349-7006.2011.02191.x
Autor:
Hayley Angove, Matthias Reule, Neil Thompson, Lynsey Fazal, Jayne Curry, John Lyons, Nicola G. Wallis
Publikováno v:
Cell Cycle. 8:1921-1929
Aurora kinases play a key role in regulating mitotic division and are attractive oncology targets. AT9283, a multi-targeted kinase inhibitor with potent activity against Aurora A and B kinases, inhibited growth and survival of multiple solid tumor ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24109a792e446794a6fc69caae338df0
https://doi.org/10.4161/cc.8.12.8741
https://doi.org/10.4161/cc.8.12.8741
Autor:
Maria Grazia Carr, Jonathan Lewis, Gary Trewartha, Ruth Feltell, Brian John Williams, Martyn Frederickson, Lina Parra, Andrew James Woodhead, Alison Jo-Anne Woolford, Joseph E. Coyle, Christopher W. Murray, Lynsey Fazal, Theresa Rachael Phillips, Donna-Michelle Smith, Rachel McMenamin, Brent Graham, Eva Figueroa, Sharna J. Rich, Gianni Chessari, M. Alistair O’Brien, Miles Congreve, Sahil Patel, Jose Cosme, David C. Rees, Robert Downham, Philip J. Day, Hayley Angove, Mladen Vinkovic
Publikováno v:
Journal of medicinal chemistry. 53(16)
Inhibitors of the molecular chaperone heat shock protein 90 (Hsp90) are currently generating significant interest in clinical development as potential treatments for cancer. In a preceding publication (DOI: 10.1021/jm100059d ) we describe Astex's app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb185c0fbb87f767299335f3ff66cf7b
https://pubmed.ncbi.nlm.nih.gov/20662534
https://pubmed.ncbi.nlm.nih.gov/20662534
Autor:
Andrew J. Woodhead, Hayley Angove, Maria G. Carr, Gianni Chessari, Miles Congreve, Joseph E. Coyle, Jose Cosme, Brent Graham, Philip J. Day, Robert Downham, Lynsey Fazal, Ruth Feltell, Eva Figueroa, Martyn Frederickson, Jonathan Lewis, Rachel McMenamin, Christopher W. Murray, M. Alistair OâBrien, Lina Parra, Sahil Patel
Publikováno v:
Journal of Medicinal Chemistry; Aug2010, Vol. 53 Issue 16, p5956-5969, 14p