Zobrazeno 1 - 10
of 455
pro vyhledávání: '"Hayflick limit"'
Autor:
Javier Curi de Bardet, Celeste Ramírez Cardentey, Belkis López González, Deanira Patrone, Idania Lores Mulet, Dario Siniscalco, María de los Angeles Robinson-Agramonte
Publikováno v:
BioTech, Vol 12, Iss 1, p 14 (2023)
Somatic human cells can divide a finite number of times, a phenomenon known as the Hayflick limit. It is based on the progressive erosion of the telomeric ends each time the cell completes a replicative cycle. Given this problem, researchers need cel
Externí odkaz:
https://doaj.org/article/021b3bc83a2e4709907ddfe2f6c28a75
Autor:
Graham Pawelec
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
T cell “exhaustion” describes a state of late-stage differentiation usually associated with active prevention of functionality via ligation of negative signaling receptors on the cell surface, and which can be reversed by blocking these interacti
Externí odkaz:
https://doaj.org/article/5b32248cddaa4047a04ce81fa0f223f1
Cancer is a leading cause of death worldwide, with approximately 18.1 million new cases and 9.6 million fatalities annually. Many studies have shown that telomeres and telomerase play crucial roles in the progression of almost all types of cancer. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af860b0d0e5648411570ca3b35334e2b
Autor:
Radhashree Maitra, Albert Dweck
Publikováno v:
Molecular Biology Reports. 48:5621-5627
Telomeres, guanine rich DNA sequences, which are found at both ends of human chromosomes, play a vital role in genome protection. These repetitive nucleotide sequences protect the genome from nucleolytic degradation, unnecessary recombination, and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f899330b8353863929a7d44df485c44
https://doi.org/10.1007/s11033-021-06496-6
https://doi.org/10.1007/s11033-021-06496-6
Akademický článek
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Publikováno v:
Open Biology, Vol 7, Iss 3 (2017)
Aberrant activation of telomerase occurs in 85–90% of all cancers and underpins the ability of cancer cells to bypass their proliferative limit, rendering them immortal. The activity of telomerase is tightly controlled at multiple levels, from tran
Externí odkaz:
https://doaj.org/article/737798b2eb9c44f5ae27c9ec1eec5496
Autor:
Jessica Franken
Publikováno v:
River Teeth: A Journal of Nonfiction Narrative. 22:107-111
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7b0fe6909029101889330982d1ceb99
https://doi.org/10.1353/rvt.2021.0010
https://doi.org/10.1353/rvt.2021.0010
Publikováno v:
Geriatrics & Gerontology International. 21:125-130
Historically, the findings from cellular lifespan studies have greatly affected aging research. The discovery of replicative senescence by Hayflick developed into research on telomeres and telomerase, while stress-induced senescence became known as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bec3f478a57d6726462fff8a4cbba31
https://doi.org/10.1111/ggi.14121
https://doi.org/10.1111/ggi.14121
Autor:
E M Samoylova, V P Baklaushev
Publikováno v:
Biochemistry (Moscow). 85:1035-1047
Our understanding of cell aging advanced significantly since the discovery of this phenomenon by Hayflick and Moorhead in 1961. In addition to the well-known shortening of telomeric regions of chromosomes, cell aging is closely associated with change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5247d8e19bf130797fcfe3339f1a3c1f
https://doi.org/10.1134/s0006297920090047
https://doi.org/10.1134/s0006297920090047
Publikováno v:
BioFactors. 46:665-674
Cell senescence is due to the permanent cell cycle arrest that occurs as a result of the inherent limited replicative capacity toward the Hayflick limit (replicative senescence), or in response to various stressors (stress-induced premature senescenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef56d835374910cb948d2788d2dc985
https://doi.org/10.1002/biof.1636
https://doi.org/10.1002/biof.1636