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Autor:
Enrico Mini, Francesca Orlandi, Luca Guandalini, Cecilia Martelli, Serena Scapecchi, Elisabetta Teodori, Ivan Bello, Maria Novella Romanelli, Cristina Bellucci, Marcella Coronnello, Silvia Dei, Dina Manetti, Hayette Menif, Milena Salerno
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:456-465
As a continuation of previous research on a new series of potent and efficacious P-gp-dependent multidrug resistant (MDR) reversers with a N,N -bis(cyclohexanol)amine scaffold, we have designed and synthesized several analogs by modulation of the two