Výsledky vyhledávání - "Hayet Pigeon"

Data from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Autor: Andreas H. Jacobs, Alexandra Winkeler, Michael Schäfers, Sven Hermann, Michael T. Kuhlmann, Cornelius Faber, Andreas Faust, Stefan Wagner, Katrin Schwegmann, Lisa Honold, Sonja Schelhaas, Inga B. Fricke, Lydia Wachsmuth, Thomas Viel, Benoit Thézé, Hayet Pigeon, Bastian Zinnhardt

The tumor microenvironment is highly heterogeneous. For gliomas, the tumor-associated inflammatory response is pivotal to support growth and invasion. Factors of glioma growth, inflammation, and invasion, such as the translocator protein (TSPO) and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ed0385b1ef2e3a703be5c3caddd1b4
https://doi.org/10.1158/0008-5472.c.6509840

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Suppl. Fig. 1: Experimental design. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Gli36dEGFR cells were implanted. Thereafter, two imaging sequences were conducted: In sequence 1, T2w MRI and PET with [18F]DPA-714 was performed, while [18F]BR-351 PET and [18F]FET PET were conducted at day 13 and 14, respectively. In imaging sequen

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https://doi.org/10.1158/0008-5472.22417415

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Suppl. Fig. 2: Workflow of imaging data co-registration. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

PET and CT images were co-registered using three CT-detectable, molecular sieve spheres (# 1-3) rinsed in radiotracer solution. After segmentation of spheres in the CT image (arrows), PET and CT images were superimposed by using the automated "Landma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ede5696d579d7e0079bf8e5fc54a84
https://doi.org/10.1158/0008-5472.22417412

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Suppl. Fig. 4: Influence of imaging sequence. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

(A) T/B ratios, (B-D) tracer volumes, (E-J) areas of unique tracer uptake and overlapping regions. No significant effect on volumetric data was observed based on the order of imaging experiments.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a843dfe71ebb02507a4270e4ee203449
https://doi.org/10.1158/0008-5472.22417406.v1

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Supplementary Figure Legends from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Supplementary Figure Legends 1-5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2d05a1603fc780b960d8a5daa99d1b
https://doi.org/10.1158/0008-5472.22417400

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Suppl. Fig. 3: Illustration of the applied thresholding. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

(A) An elliptical VOI (yellow) was drawn in the striatum. (B) Another elliptical VOI (green) was placed over the affected hemisphere. (C) After application of a thresholding based on the control VOI. The same original VOIs (left and middle) were used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2777e1bbef7baae06da639c6fe614b
https://doi.org/10.1158/0008-5472.22417409

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Suppl. Fig. 5: Assessment of intra-rater reproducibility of the volumetric relation of [18F]DPA-714 and [18F]FET. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

An exemplary subset of n=6 mice were randomly assessed for intra-rater reproducibility. (A-E) [18F]DPA-714 and [18F]FET images were on two consecutive days repeatedly co-registered. Volumetry was performed twice (coreg 2 and coreg 3) and compared to

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https://doi.org/10.1158/0008-5472.22417403

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Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Autor: Michael Schäfers, Andreas H. Jacobs, Andreas Faust, Inga B. Fricke, Thomas Viel, Stefan Wagner, Katrin Schwegmann, Cornelius Faber, Benoit Thézé, Hayet Pigeon, Bastian Zinnhardt, Lisa Honold, Alexandra Winkeler, Sven Hermann, Michael T. Kuhlmann, Sonja Schelhaas, Lydia Wachsmuth

Publikováno v: Cancer Research. 77:1831-1841

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https://doi.org/10.1158/0008-5472.can-16-2628

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TSPO-PET and diffusion-weighted MRI for imaging a mouse model of infiltrative human glioma

Autor: Elodie A. Pérès, Charles Truillet, Denis Le Bihan, Fabien Caillé, Bastian Zinnhardt, Benoit Jego, Andreas H. Jacobs, Alexandra Winkeler, Fawzi Boumezbeur, Hayet Pigeon

Publikováno v: Neuro Oncol

BACKGROUND: Glioblastoma (GBM) is the most devastating brain tumor. Despite the use of multimodal treatments, most patients relapse, often due to the highly invasive nature of gliomas. However, the detection of glioma infiltration remains challenging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ab10105e609fc854514b0520e6a04f
https://pubmed.ncbi.nlm.nih.gov/30721979

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