Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

Autor: Pervjakova, Natalia, Moen, Gunn-Helen Øiseth, Borges, Maria-Carolina, Ferreira, Teresa, Cook, James P., Allard, Catherine, Beaumont, Robin N., Canouil, Mickaël, Hatem, Gad, Heiskala, Anni, Joensuu, Anni, Karhunen, Ville, Kwak, Soo Heon, Lin, Frederick T J, Liu, Jun, Rifas-Shiman, Sheryl, Tam, Claudia H., Tam, Wing Hung, Thorleifsson, Gudmar, Andrew, Toby, Auvinen, Juha, Bhowmik, Bishwajit, Bonnefond, Amélie, Delahaye, Fabien, Demirkan, Ayse, Froguel, Philippe, Haller-Kikkatalo, Kadri, Hardardottir, Hildur, Hummel, Sandra, Hussain, Akhtar, Kajantie, Eero Olavi, Keikkala, Elina, Khamis, Amna, Lahti, Jari, Lekva, Tove, Mustaniemi, Sanna, Sommer, Christine, Tagoma, Aili, Tzala, Evangelia, Uibo, Raivo, Vääräsmäki, Marja, Villa, Pia M., Birkeland, Kåre Inge, Bouchard, Luigi, Duijn, Cornelia M., Finer, Sarah, Groop, Leif, Hämäläinen, Esa, Hayes, Geoffrey M., Hitman, Graham A., Jang, Hak C., Järvelin, Marjo-Riitta, Jenum, Anne Karen, Laivuori, Hannele, Ma, Ronald C., Melander, Olle, Oken, Emily, Park, Kyong Soo, Perron, Patrice, Prasad, Rashmi B., Qvigstad, Elisabeth, Sebert, Sylvain, Stefansson, Kari, Steinthorsdottir, Valgerdur, Tuomi, Tiinamaija, Hivert, Marie-France, Franks, Paul W., McCarthy, Mark I., Lindgren, Cecilia M., Freathy, Rachel M., Lawlor, Deborah A., Morris, Andrew P., Mägi, Reedik

Publikováno v: Pervjakova, Natalia Moen, Gunn-Helen Øiseth Borges, Maria-Carolina Ferreira, Teresa Cook, James P. Allard, Catherine Beaumont, Robin N. Canouil, Mickaël Hatem, Gad Heiskala, Anni Joensuu, Anni Karhunen, Ville Kwak, Soo Heon Lin, Frederick T J Liu, Jun Rifas-Shiman, Sheryl Tam, Claudia H. Tam, Wing Hung Thorleifsson, Gudmar Andrew, Toby Auvinen, Juha Bhowmik, Bishwajit Bonnefond, Amélie Delahaye, Fabien Demirkan, Ayse Froguel, Philippe Haller-Kikkatalo, Kadri Hardardottir, Hildur Hummel, Sandra Hussain, Akhtar Kajantie, Eero Olavi Keikkala, Elina Khamis, Amna Lahti, Jari Lekva, Tove Mustaniemi, Sanna Sommer, Christine Tagoma, Aili Tzala, Evangelia Uibo, Raivo Vääräsmäki, Marja Villa, Pia M. Birkeland, Kåre Inge Bouchard, Luigi Duijn, Cornelia M. Finer, Sarah Groop, Leif Hämäläinen, Esa Hayes, Geoffrey M. Hitman, Graham A. Jang, Hak C. Järvelin, Marjo-Riitta Jenum, Anne Karen Laivuori, Hannele Ma, Ronald C. Melander, Olle Oken, Emily Park, Kyong Soo Perron, Patrice Prasad, Rashmi B. Qvigstad, Elisabeth Sebert, Sylvain Stefansson, Kari Steinthorsdottir, Valgerdur Tuomi, Tiinamaija Hivert, Marie-France Franks, Paul W. McCarthy, Mark I. Lindgren, Cecilia M. Freathy, Rachel M. Lawlor, Deborah A. Morris, Andrew P. Mägi, Reedik . Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes. Human Molecular Genetics. 2022, 31(19), 3377-3391
Human Molecular Genetics

Externí odkaz: http://hdl.handle.net/10852/97570

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes.

Autor: Pervjakova N; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu 51010, Estonia., Moen GH; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Diamantina Institute, The University of Queensland, Woolloongabba QLD 4102, Australia.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Borges MC; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Ferreira T; Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK., Cook JP; Department of Health Data Science, University of Liverpool, Liverpool, UK., Allard C; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Universite de Sherbrooke, Quebec, Canada., Beaumont RN; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, UK., Canouil M; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille F-59000, France.; University of Lille, Lille University Hospital, Lille F-59000, France., Hatem G; Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund University Diabetes Centre, Malmö SE-20502, Sweden., Heiskala A; Centre for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Joensuu A; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Karhunen V; Centre for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Hospital, London, UK., Kwak SH; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea., Lin FTJ; Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Liu J; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Rifas-Shiman S; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA., Tam CH; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, The People's Republic of China., Tam WH; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, The People's Republic of China., Thorleifsson G; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Andrew T; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille F-59000, France.; University of Lille, Lille University Hospital, Lille F-59000, France.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Auvinen J; Centre for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Bhowmik B; Centre of Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh., Bonnefond A; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille F-59000, France.; University of Lille, Lille University Hospital, Lille F-59000, France.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Delahaye F; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille F-59000, France.; University of Lille, Lille University Hospital, Lille F-59000, France., Demirkan A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Section of Statistical Multi-omics, Department of Clinical and Experimental Research, University of Surrey, Surrey, UK., Froguel P; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille F-59000, France.; University of Lille, Lille University Hospital, Lille F-59000, France.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Haller-Kikkatalo K; Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Hardardottir H; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Livio Reykjavik, Reykjavik, Iceland., Hummel S; Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.; Forschergruppe Diabetes, Technical University Munich, at Klinikum rechts der Isar, Munich, Germany., Hussain A; Centre of Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh.; Faculty of Health Sciences, Nord University, Bodø, Norway., Kajantie E; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Keikkala E; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Khamis A; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille F-59000, France.; University of Lille, Lille University Hospital, Lille F-59000, France.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Lahti J; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland., Lekva T; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway., Mustaniemi S; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Sommer C; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway., Tagoma A; Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Tzala E; School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Hospital, London, UK., Uibo R; Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Vääräsmäki M; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland., Villa PM; Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Hyvinkää Hospital, Helsinki and Uusimaa Hospital District, Hyvinkää, Finland., Birkeland KI; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway., Bouchard L; Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Quebec, Canada.; Department of Medical Biology, Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay-Lac-St-Jean - Hôpital de Chicoutimi, Québec, Canada., Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Finer S; Centre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Groop L; Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund University Diabetes Centre, Malmö SE-20502, Sweden.; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Hämäläinen E; Department of Clinical Chemistry, University of Eastern Finland, Kuopio, Finland., Hayes GM; Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.; Department of Anthropology, Northwestern University, Evanston, IL 60208, USA., Hitman GA; Centre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Jang HC; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Järvelin MR; Centre for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Hospital, London, UK., Jenum AK; General Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, Faculty of Medicine, University of Oslo, Post Box 1130 Blindern, Oslo 0318, Norway., Laivuori H; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Department of Obstetrics and Gynecology, Tampere University, Hospital and Faculty of Medicine and Health Technology, Center for Child, Adolescent, and Maternal Health, Tampere University, Tampere, Finland.; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Ma RC; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, The People's Republic of China.; Laboratory for Molecular Epidemiology in Diabetes, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, The People's Republic of China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, The People's Republic of China., Melander O; Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund University Diabetes Centre, Malmö SE-20502, Sweden., Oken E; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA., Park KS; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea., Perron P; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Universite de Sherbrooke, Quebec, Canada.; Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrook, Québec, Canada., Prasad RB; Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund University Diabetes Centre, Malmö SE-20502, Sweden., Qvigstad E; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Sebert S; Centre for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Stefansson K; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Steinthorsdottir V; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Tuomi T; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund University Diabetes Centre, Malmö SE-20502, Sweden.; Department of Endocrinology, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland.; Folkhalsan Research Center, Helsinki, Finland., Hivert MF; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrook, Québec, Canada.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Franks PW; Department of Clinical Sciences, Lund University, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA., McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Lindgren CM; Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Program in Medical and Population Genetics, Broad Institute, Boston, MA, USA., Freathy RM; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, UK., Lawlor DA; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol NIHR Biomedical Research Centre, Bristol, UK., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2022 Sep 29; Vol. 31 (19), pp. 3377-3391.