Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hayeong Kwon"'
Publikováno v:
Cancer Gene Therapy. 30:302-312
We have shown that insulin-like growth factor-1 (IGF-1) induces palmitoylation turnover of Flotillin-1 (Flot-1) in the plasma membrane (PM) for cell proliferation, after IGF-1 receptor (IGF-1R) signaling activation. However, the enzymes responsible f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbb20ce79a0e48196fbabe3de222de7
https://doi.org/10.1038/s41417-022-00546-2
https://doi.org/10.1038/s41417-022-00546-2
Publikováno v:
The FASEB Journal. 37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c4538ebc45b03de36101b5c96771a5b
https://doi.org/10.1096/fj.202201028rr
https://doi.org/10.1096/fj.202201028rr
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1869(12)
Here, we show that Caveolin-2 (Cav-2) is an epigenetic regulator for adipogenesis. Upon adipogenic stimulation, inner nuclear membrane (INM)-targeted pY19-Cav-2 interacted with lamin A/C to disengage the repressed Cebpb promoter from lamin A/C, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7405537aa1b05b9d0cfb59320c70011
https://pubmed.ncbi.nlm.nih.gov/36165916
https://pubmed.ncbi.nlm.nih.gov/36165916
Publikováno v:
Biochemical and Biophysical Research Communications. 532:535-540
N-myristoylation is a ubiquitous protein lipidation in eukaryotes, but regulatory roles for myristoylation on proteins still remain to be explored. Here, we show that N-myristoylation of Caveolin-2 (Cav-2) controls insulin signaling. Alternative tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7412b4a8735f8b8cff4c66f1d8650c4f
https://doi.org/10.1016/j.bbrc.2020.08.072
https://doi.org/10.1016/j.bbrc.2020.08.072
Publikováno v:
Oncogene
Flotillin-1 (Flot-1) has been shown to regulate cancer progression, but the regulatory role of post-translational modifications of Flot-1 on cancers remains elusive. Herein, we show that up-regulated E2 conjugating enzyme UBC9 sumoylates Flot-1 at Ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bee0b30e1cef2f87b62334369c6b0c8
https://doi.org/10.1038/s41388-018-0641-1
https://doi.org/10.1038/s41388-018-0641-1
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1864:2169-2182
Insulin resistance, defined as attenuated sensitivity responding to insulin, impairs insulin action. Direct causes and molecular mechanisms of insulin resistance have thus far remained elusive. Here we show that alternative translation initiation (AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e60a98400f047676fd75a283674f55
https://doi.org/10.1016/j.bbadis.2018.03.022
https://doi.org/10.1016/j.bbadis.2018.03.022
Publikováno v:
Journal of Cell Science. 128:2179-2190
Here, we explored flotillin-1-mediated regulation of insulin-like growth factor-1 (IGF-1) signaling. Flotillin-1-deficient cells exhibited a reduction in the activation of IGF-1 receptor (IGF-1R), ERK1/2 and Akt pathways, and the transcriptional acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f3acc8fddf245a7819b2c65a7fe665
https://doi.org/10.1242/jcs.169409
https://doi.org/10.1242/jcs.169409
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1853:1022-1034
Here, we demonstrate that insulin receptor (IR) tyrosine kinase catalyzes Tyr-19 and Tyr-27 phosphorylation of caveolin-2 (cav-2), leading to stimulation of signaling proteins downstream of IR, and that the catalysis is dependent on fatty acylation s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f4547b3bccb43ba3726096ad4ea815
https://doi.org/10.1016/j.bbamcr.2015.02.002
https://doi.org/10.1016/j.bbamcr.2015.02.002
Publikováno v:
Biochimica et biophysica acta. 1863(11)
Association of Caveolin-2 in the inner nuclear membrane specifically with A-type lamin is crucial for the maintenance of its Tyr-19 phosphorylation to promote insulin-response epigenetic activation at the nuclear periphery. Here, we identify that pY1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10c1ba3ba9113de33bf10fd2387a465
https://pubmed.ncbi.nlm.nih.gov/27552914
https://pubmed.ncbi.nlm.nih.gov/27552914
Autor:
Donghwan Jang, Eun Mi Hwang, Kyuho Jeong, Jaewoong Lee, Yunbae Pak, Hayeong Kwon, Jae Yong Park
Publikováno v:
Traffic. 13:1218-1233
Here, we have identified a retrograde transport pathway of caveolin-2 (cav-2) for its regulatory function in the nucleus. Confocal microscopy analysis, photoactivation experiments and subcellular fractionation revealed that cav-2 localized in the Gol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8acfc6d0fda28fbb9e35f33391c51b2
https://doi.org/10.1111/j.1600-0854.2012.01378.x
https://doi.org/10.1111/j.1600-0854.2012.01378.x