The NADPH oxidase NOX2 is a marker of adverse prognosis involved in chemoresistance of acute myeloid leukemias

Autor: Rosa Paolillo, Mathias Boulanger, Pierre Gâtel, Ludovic Gabellier, Marion De Toledo, Denis Tempé, Rawan Hallal, Dana Akl, Jérôme Moreaux, Hayeon Baik, Elise Gueret, Christian Recher, Jean-Emmanuel Sarry, Guillaume Cartron, Marc Piechaczyk, Guillaume Bossis

Publikováno v: Haematologica, Vol 107, Iss 11 (2022)

Resistance to chemotherapeutic drugs is a major cause of treatment failure in acute myeloid leukemias (AML). To better characterize the mechanisms of chemoresistance, we first identified genes whose expression is dysregulated in AML cells resistant t

Externí odkaz: https://doaj.org/article/693f4bfe8c834a5588ccd2b699cb8b45

Supplementary Figures from Targeting the SUMO Pathway Primes All-trans Retinoic Acid–Induced Differentiation of Nonpromyelocytic Acute Myeloid Leukemias

Autor: Guillaume Bossis, Marc Piechaczyk, Guillaume Cartron, Yosr Hicheri, Jean-Emmanuel Sarry, Tamara Salem, Sonia Zaghdoudi, Julie Kowalczyk, Mohsen Hosseini, Mathias Boulanger, Hayeon Baik

Supplementary Figure 1: Inhibition of SUMOylation increases morphological changes associated with ATRA-induced differentiation. Supplementary Figure 2: Effect of SENP overexpression on total and chromatin bound proteins. Supplementary Figure 3: Inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e328d77fafeade39b4115c7cedb699ac
https://doi.org/10.1158/0008-5472.22419819

Supplementary Table 1 from Targeting the SUMO Pathway Primes All-trans Retinoic Acid–Induced Differentiation of Nonpromyelocytic Acute Myeloid Leukemias

Autor: Guillaume Bossis, Marc Piechaczyk, Guillaume Cartron, Yosr Hicheri, Jean-Emmanuel Sarry, Tamara Salem, Sonia Zaghdoudi, Julie Kowalczyk, Mohsen Hosseini, Mathias Boulanger, Hayeon Baik

Supplementary Table 1: Characteristics of all patients used in Figure 7 or Supplementary Figure 4. D: diagnosis, R:relapse. For the molecular characteristics, only those routinely clinically tested are indicated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db78aa83082616609520a420d91dda3
https://doi.org/10.1158/0008-5472.22419816.v1

Characterisation of Extracellular Vesicles from Equine Mesenchymal Stem Cells

Autor: Robert Soukup, Iris Gerner, Sinan Gültekin, Hayeon Baik, Johannes Oesterreicher, Johannes Grillari, Florien Jenner

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5858

Extracellular vesicles (EVs) are nanosized lipid bilayer-encapsulated particles secreted by virtually all cell types. EVs play an essential role in cellular crosstalk in health and disease. The cellular origin of EVs determines their composition and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1dffaa404b63efe8c8f081271a1899
https://pubmed.ncbi.nlm.nih.gov/35628667

Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite

Autor: Mark A. T. Blaskovich, Alysha G. Elliott, Christina I. Schroeder, Rajeshwari Meli, Séverine Morisset-Lopez, Hue N. T. Tran, Sabrina Spiller, Hayeon Baik, Nayara Braga Emidio, Markus Muttenthaler, Annette G. Beck-Sickinger

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (13), pp.9484-9495. ⟨10.1021/acs.jmedchem.1c00767⟩
Journal of Medicinal Chemistry, 2021, 64 (13), pp.9484-9495. ⟨10.1021/acs.jmedchem.1c00767⟩

International audience; TFF3 regulates essential gastro- and neuroprotective functions, but its molecular mode of action remains poorly understood. Synthetic intractability and lack of reliable bioassays and validated receptors are bottlenecks for me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e711806df3a34b8bee790ad9eaf8c0
https://hal.archives-ouvertes.fr/hal-03335490