Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies

Autor: Lozano-Ojalvo, Daniel, Benedé, Sara, Antunes, Celia M., Bavaro, Simona L., Bouchaud, Grégory, Costa, Ana, Denery-Papini, Sandra, Díaz-Perales, Araceli, Garrido-Arandia, María, Gavrovic-Jankulovic, Marija, Hayen, Simone, Martínez-Blanco, Mónica, Molina, Elena, Monaci, Linda, Pieters, Raymond H.H., Villemin, Clelia, Wichers, Harry J., Wróblewska, Barbara, Willemsen, Linette E.M., Roggen, Erwin L., van Bilsen, Jolanda H.M.

Publikováno v: In Trends in Food Science & Technology March 2019 85:307-319

Combined Exposure of Activated Intestinal Epithelial Cells to Nondigestible Oligosaccharides and CpG-ODN Suppresses Th2-Associated CCL22 Release while Enhancing Galectin-9, TGF β, and Th1 Polarization

Autor: Overbeek, Saskia A, Kostadinova, Atanaska I, Boks, Martine A, Hayen, Simone M, de Jager, Wilco, Van't Land, Belinda, Knippels, Leon M, Garssen, Johan, Willemsen, Linette E M, Afd Pharmacology, Pharmacology

Publikováno v: Mediators of Inflammation
Mediators of Inflammation, 2019:8456829. Hindawi Publishing Corporation
Mediators of Inflammation, Vol 2019 (2019)
Mediators of Inflammation, 2019. Hindawi Publishing Corporation
Overbeek, S A, Kostadinova, A I, Boks, M A, Hayen, S M, de Jager, W, van't Land, B, Knippels, L M, Garssen, J & Willemsen, L E M 2019, ' Combined Exposure of Activated Intestinal Epithelial Cells to Nondigestible Oligosaccharides and CpG-ODN Suppresses Th2-Associated CCL22 Release while Enhancing Galectin-9, TGF β, and Th1 Polarization ', Mediators of Inflammation, vol. 2019, 8456829 . https://doi.org/10.1155/2019/8456829

Background. Short-chain galacto- and long-chain fructo-oligosaccharides (scGOS/lcFOS) and CpG-ODN affect intestinal epithelial cells (IEC). Epithelial IL1α may contribute to allergic sensitization via autocrine mediator release affecting dendritic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4e326c97e9b757fbf18e348023c385
https://doi.org/10.1155/2019/8456829

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Novel immunotherapy approaches to food allergy

Autor: Hayen, Simone M, Kostadinova, Atanaska I, Garssen, Johan, Otten, Henny G, Willemsen, Linette E M, Sub General Pharmacology, Sub Immunopharmacology, Pharmacology

Publikováno v: Current Opinion in Allergy and Clinical Immunology, 14(6), 549. Lippincott Williams and Wilkins

PURPOSE OF REVIEW: Despite reaching high percentages of desensitization using allergen-specific immunotherapy (SIT) in patients with food allergy, recent studies suggest only a low number of patients to reach persistent clinical tolerance. This revie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5523b417e4b61f2e2024cb61d866b1f
https://dspace.library.uu.nl/handle/1874/304268