Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Hayel, Tuncel"'
Autor:
Hayel Tuncel, Denise Visser, Tessa Timmers, Emma E. Wolters, Rik Ossenkoppele, Wiesje M. van der Flier, Bart N. M. van Berckel, Ronald Boellaard, Sandeep S. V. Golla
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Background Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery (R1), which is a proxy for relative cerebral blood flow (rCBF). Recently, studies suggested that R1 obtained
Externí odkaz:
https://doaj.org/article/5b92fa28a272466696c487ff5bf1f7c8
Autor:
Hayel Tuncel, Ronald Boellaard, Emma M. Coomans, Marijke den Hollander-Meeuwsen, Erik F. J. de Vries, Andor W. J. M. Glaudemans, Paula Kopschina Feltes, David Vállez García, Sander C. J. Verfaillie, Emma E. Wolters, Steven P. Sweeney, J. Michael Ryan, Magnus Ivarsson, Berkley A. Lynch, Patrick Schober, Philip Scheltens, Robert C. Schuit, Albert D. Windhorst, Peter P. De Deyn, Bart N. M. van Berckel, Sandeep S. V. Golla
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract [11C]UCB-J is a PET radioligand that binds to the presynaptic vesicle glycoprotein 2A. Therefore, [11C]UCB-J PET may serve as an in vivo marker of synaptic integrity. The main objective of this study was to evaluate the quantitative accuracy
Externí odkaz:
https://doaj.org/article/1d98093e987342dd9416579091feee0d
Autor:
Emma M. Coomans, Deborah N. Schoonhoven, Hayel Tuncel, Sander C. J. Verfaillie, Emma E. Wolters, Ronald Boellaard, Rik Ossenkoppele, Anouk den Braber, Wiep Scheper, Patrick Schober, Steven P. Sweeney, J. Michael Ryan, Robert C. Schuit, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Sandeep S. V. Golla, Arjan Hillebrand, Alida A. Gouw, Bart N. M. van Berckel
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background The mechanism of synaptic loss in Alzheimer’s disease is poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) and magnetoencephalography (MEG) study, we aimed to investi
Externí odkaz:
https://doaj.org/article/0311b602bb364b2b9a39d6b57ce39995
Autor:
Denise Visser, Sander C. J. Verfaillie, Iris Bosch, Iman Brouwer, Hayel Tuncel, Emma M. Coomans, Roos M. Rikken, Sophie E. Mastenbroek, Sandeep S. V. Golla, Frederik Barkhof, Elsmarieke van de Giessen, Bart N. M. van Berckel, Wiesje M. van der Flier, Rik Ossenkoppele
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging, 50(8), 2409-2419. Springer Verlag
Visser, D, Verfaillie, S C J, Bosch, I, Brouwer, I, Tuncel, H, Coomans, E M, Rikken, R M, Mastenbroek, S E, Golla, S S V, Barkhof, F, van de Giessen, E, van Berckel, B N M, van der Flier, W M & Ossenkoppele, R 2023, ' Tau pathology as determinant of changes in atrophy and cerebral blood flow : a multi-modal longitudinal imaging study ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 50, no. 8, pp. 2409-2419 . https://doi.org/10.1007/s00259-023-06196-2
Visser, D, Verfaillie, S C J, Bosch, I, Brouwer, I, Tuncel, H, Coomans, E M, Rikken, R M, Mastenbroek, S E, Golla, S S V, Barkhof, F, van de Giessen, E, van Berckel, B N M, van der Flier, W M & Ossenkoppele, R 2023, ' Tau pathology as determinant of changes in atrophy and cerebral blood flow : a multi-modal longitudinal imaging study ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 50, no. 8, pp. 2409-2419 . https://doi.org/10.1007/s00259-023-06196-2
Purpose Tau pathology is associated with concurrent atrophy and decreased cerebral blood flow (CBF) in Alzheimer’s disease (AD), but less is known about their temporal relationships. Our aim was therefore to investigate the association of concurren
A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer's Disease Continuum
Autor:
Emma M. Coomans, Inge M.W. Verberk, Rik Ossenkoppele, Sander C.J. Verfaillie, Denise Visser, Mariam Gouda, Hayel Tuncel, Emma E. Wolters, Tessa Timmers, Albert D. Windhorst, Sandeep S.V. Golla, Philip Scheltens, Wiesje M. van, der Flier, Bart N.M. van Berckel, Charlotte E. Teunissen
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 64(3), 437-443
Coomans, E M, Verberk, I M W, Ossenkoppele, R, Verfaillie, S C J, Visser, D, Gouda, M, Tuncel, H, Wolters, E E, Timmers, T, Windhorst, A D, Golla, S S V, Scheltens, P, van, W M, Flier, D, van Berckel, B N M & Teunissen, C E 2023, ' A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer's Disease Continuum ', Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol. 64, no. 3, pp. 437-443 . https://doi.org/10.2967/jnumed.122.264279
Coomans, E M, Verberk, I M W, Ossenkoppele, R, Verfaillie, S C J, Visser, D, Gouda, M, Tuncel, H, Wolters, E E, Timmers, T, Windhorst, A D, Golla, S S V, Scheltens, P, van, W M, Flier, D, van Berckel, B N M & Teunissen, C E 2023, ' A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer's Disease Continuum ', Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol. 64, no. 3, pp. 437-443 . https://doi.org/10.2967/jnumed.122.264279
Both plasma tau phosphorylated at threonine-181 (pTau181) and tau PET show potential for detecting Alzheimer’s disease (AD) pathology and predicting clinical progression. In this study, we performed a head-to-head comparison between plasma pTau181
Autor:
Emma E Wolters, Rik Ossenkoppele, Sandeep SV Golla, Sander CJ Verfaillie, Tessa Timmers, Denise Visser, Hayel Tuncel, Emma M Coomans, Albert D Windhorst, Philip Scheltens, Wiesje M van der Flier, Ronald Boellaard, Bart NM van Berckel
Publikováno v:
NeuroImage: Clinical, Vol 25, Iss , Pp - (2020)
Background: Off-target [18F]flortaucipir (tau) PET binding in the choroid plexus causes spill-in into the nearby hippocampus, which may influence the correlation between [18F]flortaucipir binding and measures of cognition. Previously, we showed that
Externí odkaz:
https://doaj.org/article/a5bfc3b33d724e1bbda4df8af87d3498
Autor:
Denise Visser, Hayel Tuncel, Rik Ossenkoppele, Maqsood Yaqub, Emma E. Wolters, Tessa Timmers, Emma Weltings, Emma M. Coomans, Marijke E. den Hollander, Wiesje M. van der Flier, Bart N.M. van Berckel, Sandeep S.V. Golla
Publikováno v:
Journal of Nuclear Medicine. 64:281-286
Autor:
Deborah N Schoonhoven, Emma M Coomans, Ana P Millan, Anne M van Nifterick, Denise Visser, Rik Ossenkoppele, Hayel Tuncel, Wiesje M. van der Flier, Sandeep SV Golla, Philip Scheltens, Arjan Hillebrand, Bart NM van Berckel, Cornelis J Stam, Alida A Gouw
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Maurits Johansson, William G. Mantyh, Renaud La Joie, Sandeep S.V. Golla, Pontus Tideman, Amelia Strom, John C. van Swieten, Ellen H. Singleton, Anke A. Dijkstra, Evi Berendrecht, Philip Scheltens, Emma M. Coomans, Antoine Leuzy, Rik Ossenkoppele, Gil D. Rabinovici, Emma E. Wolters, Leonardo Iaccarino, Erik Stomrud, Hayel Tuncel, Janne M. Papma, Lauren Edwards, Bart N.M. van Berckel, Olof Strandberg, Femke H. Bouwman, Oskar Hansson, Bruce L. Miller, Ruben Smith, Denise Visser, Yolande A.L. Pijnenburg
Publikováno v:
Journal of Neurology, Neurosurgery and Psychiatry, 92(8), 872-880. BMJ Publishing Group
Journal of neurology, neurosurgery, and psychiatry, vol 92, iss 8
Journal of Neurology, Neurosurgery, and Psychiatry
Singleton, E, Hansson, O, Pijnenburg, Y A L, la Joie, R, Mantyh, W G, Tideman, P, Stomrud, E, Leuzy, A, Johansson, M, Strandberg, O, Smith, R, Berendrecht, E, Miller, B L, Iaccarino, L, Edwards, L, Strom, A, Wolters, E E, Coomans, E, Visser, D, Golla, S S V, Tuncel, H, Bouwman, F, van Swieten, J C, Papma, J M, van Berckel, B, Scheltens, P, Dijkstra, A A, Rabinovici, G D & Ossenkoppele, R 2021, ' Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 92, no. 8, pp. 872-880 . https://doi.org/10.1136/jnnp-2020-325497
Journal of neurology, neurosurgery, and psychiatry, vol 92, iss 8
Journal of Neurology, Neurosurgery, and Psychiatry
Singleton, E, Hansson, O, Pijnenburg, Y A L, la Joie, R, Mantyh, W G, Tideman, P, Stomrud, E, Leuzy, A, Johansson, M, Strandberg, O, Smith, R, Berendrecht, E, Miller, B L, Iaccarino, L, Edwards, L, Strom, A, Wolters, E E, Coomans, E, Visser, D, Golla, S S V, Tuncel, H, Bouwman, F, van Swieten, J C, Papma, J M, van Berckel, B, Scheltens, P, Dijkstra, A A, Rabinovici, G D & Ossenkoppele, R 2021, ' Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 92, no. 8, pp. 872-880 . https://doi.org/10.1136/jnnp-2020-325497
ObjectiveThe clinical phenotype of the rare behavioural variant of Alzheimer’s disease (bvAD) is insufficiently understood. Given the strong clinico-anatomical correlations of tau pathology in AD, we investigated the distribution of tau deposits in
Autor:
Rik Ossenkoppele, Ronald Boellaard, Hayel Tuncel, Bart N.M. van Berckel, Tessa Timmers, Emma E. Wolters, Maqsood Yaqub, Denise Visser, Wiesje M. van der Flier, Sandeep S.V. Golla
Publikováno v:
Molecular Imaging and Biology, 23(4), 604-613. Springer New York
Tuncel, H, Visser, D, Yaqub, M, Timmers, T, Wolters, E E, Ossenkoppele, R, van der Flier, W M, van Berckel, B N M, Boellaard, R & Golla, S S V 2021, ' Effect of Shortening the Scan Duration on Quantitative Accuracy of [18F]Flortaucipir Studies ', Molecular Imaging and Biology, vol. 23, no. 4, pp. 604-613 . https://doi.org/10.1007/s11307-021-01581-5
Tuncel, H, Visser, D, Yaqub, M, Timmers, T, Wolters, E E, Ossenkoppele, R, van der Flier, W M, van Berckel, B N M, Boellaard, R & Golla, S S V 2021, ' Effect of Shortening the Scan Duration on Quantitative Accuracy of [18F]Flortaucipir Studies ', Molecular Imaging and Biology, vol. 23, no. 4, pp. 604-613 . https://doi.org/10.1007/s11307-021-01581-5
Purpose Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [18F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration of 130 min. The current study