Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Haydyn D. T. Mertens"'
Autor:
Clement E. Blanchet, Adam Round, Haydyn D. T. Mertens, Kartik Ayyer, Melissa Graewert, Salah Awel, Daniel Franke, Katerina Dörner, Saša Bajt, Richard Bean, Tânia F. Custódio, Raphael de Wijn, E. Juncheng, Alessandra Henkel, Andrey Gruzinov, Cy M. Jeffries, Yoonhee Kim, Henry Kirkwood, Marco Kloos, Juraj Knoška, Jayanath Koliyadu, Romain Letrun, Christian Löw, Jana Makroczyova, Abhishek Mall, Rob Meijers, Gisel Esperanza Pena Murillo, Dominik Oberthür, Ekaterina Round, Carolin Seuring, Marcin Sikorski, Patrik Vagovic, Joana Valerio, Tamme Wollweber, Yulong Zhuang, Joachim Schulz, Heinrich Haas, Henry N. Chapman, Adrian P. Mancuso, Dmitri Svergun
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Free-electron lasers (FEL) are revolutionizing X-ray-based structural biology methods. While protein crystallography is already routinely performed at FELs, Small Angle X-ray Scattering (SAXS) studies of biological macromolecules are not as
Externí odkaz:
https://doaj.org/article/bcf514c39af3436883cc2c8e5bf81aab
Autor:
Anandhi Anandan, Nicholas W. Dunstan, Timothy M. Ryan, Haydyn D. T. Mertens, Katherine Y. L. Lim, Genevieve L. Evans, Charlene M. Kahler, Alice Vrielink
Publikováno v:
IUCrJ, Vol 8, Iss 5, Pp 732-746 (2021)
Many pathogenic gram-negative bacteria have developed mechanisms to increase resistance to cationic antimicrobial peptides by modifying the lipid A moiety. One modification is the addition of phosphoethanolamine to lipid A by the enzyme phosphoethano
Externí odkaz:
https://doaj.org/article/cbc165d2c27747119717a3d4bd3ba62d
Autor:
Javier Lizarrondo, David P. Klebl, Stephan Niebling, Marc Abella, Martin A. Schroer, Haydyn D. T. Mertens, Katharina Veith, Roland Thuenauer, Dmitri I. Svergun, Michal Skruzny, Frank Sobott, Stephen P. Muench, Maria M. Garcia-Alai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
During clathrin-mediated endocytosis in yeast, endocytic coat adaptors, Sla2 and Ent1, must remain attached to the plasma membrane to transmit force from the actin cytoskeleton required for membrane invagination. Here authors present a cryo-EM struct
Externí odkaz:
https://doaj.org/article/c76a9156443143ecaad0091e2cec9c08
Autor:
Maxime Killer, Giada Finocchio, Haydyn D. T. Mertens, Dmitri I. Svergun, Els Pardon, Jan Steyaert, Christian Löw
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Proton-coupled Oligopeptide Transporters (POTs) of the Major Facilitator Superfamily (MFS) mediate the uptake of short di- and tripeptides in all phyla of life. POTs are thought to constitute the most promiscuous class of MFS transporters, with the p
Externí odkaz:
https://doaj.org/article/5cb777101f174f9e8283dfff8af7a4b7
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 157 (2023)
Proteins are inherently unstable, which limits their use as therapeutic agents. However, the use of biocompatible cosolvents or surfactants can help to circumvent this problem through the stabilization of intramolecular and solvent-mediated interacti
Externí odkaz:
https://doaj.org/article/7447fedc2b514c4c86b6cf1f04e90aa7
Publikováno v:
Nanomaterials, Vol 12, Iss 6, p 893 (2022)
Phenylketonuria (PKU) is an autosomal recessive disease caused by deficient activity of human phenylalanine hydroxylase (hPAH), which can lead to neurologic impairments in untreated patients. Although some therapies are already available for PKU, the
Externí odkaz:
https://doaj.org/article/a7dabc6783a14f708d32650f61432399
Autor:
Maria M. Garcia-Alai, Johannes Heidemann, Michal Skruzny, Anna Gieras, Haydyn D. T. Mertens, Dmitri I. Svergun, Marko Kaksonen, Charlotte Uetrecht, Rob Meijers
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Adapter proteins assist clathrin coated pit assembly. Here, the authors combine native mass spectrometry, crystallography and SAXS measurements and show that the membrane–proximal domains of the adaptor proteins epsin and Sla2 form complexes mediat
Externí odkaz:
https://doaj.org/article/3b231f81fed242b185fa1a34c644ce5f
Publikováno v:
IUCrJ, Vol 2, Iss 2, Pp 207-217 (2015)
Dynamic ensembles of macromolecules mediate essential processes in biology. Understanding the mechanisms driving the function and molecular interactions of `unstructured' and flexible molecules requires alternative approaches to those traditionally e
Externí odkaz:
https://doaj.org/article/941cf0fe31f74c789abb424b8a0986a7
Autor:
Nicholas W Dunstan, Anandhi Anandan, Timothy M. Ryan, Genevieve L. Evans, Katherine Y. L. Lim, Charlene M. Kahler, Alice Vrielink, Haydyn D. T. Mertens
Publikováno v:
IUCrJ, Vol 8, Iss 5, Pp 732-746 (2021)
IUCrJ
IUCrJ
Small-angle X-ray scattering and tryptophan fluorescence studies of phosphoethanolamine transferase (EptA) suggest conformational flexibility linked to enzyme activity.
Many pathogenic gram-negative bacteria have developed mechanisms to incr
Many pathogenic gram-negative bacteria have developed mechanisms to incr
Autor:
Goksin Liu, Erhan Ekmen, Farzaneh Jalalypour, Haydyn D. T. Mertens, Cy M. Jeffries, Dmitri Svergun, Ali Rana Atilgan, Canan Atilgan, Zehra Sayers
Publikováno v:
The journal of chemical physics 158(8), 085101 (2023). doi:10.1063/5.0136558
The journal of chemical physics 158(8), 085101 (2023). doi:10.1063/5.0136558
This study combines molecular dynamics (MD) simulations with small angle x-ray scattering (SAXS) measurements to investigate the range of conformations that can be adop
This study combines molecular dynamics (MD) simulations with small angle x-ray scattering (SAXS) measurements to investigate the range of conformations that can be adop