A Survey of Transcription Factors in Cell Fate Control

Autor: Emal Lesha, Haydy George, Mark M. Zaki, Cory J. Smith, Parastoo Khoshakhlagh, Alex H. M. Ng

Publikováno v: Transcription Factor Regulatory Networks ISBN: 9781071628140

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5702651f0d6b7a46be36ccfd28cbe04f
https://doi.org/10.1007/978-1-0716-2815-7_10

Extensive germline genome engineering in pigs

Autor: Violette Paragas, Jacob V. Layer, Marc Güell, William F. Westlin, Luhan Yang, Juan Xiong, Weilin Wang, Shengyi Mao, Yinan Kan, Ranjith P. Anand, Deling Jiao, Zhongquan Sun, Mengyuan Xu, George M. Church, Lydia Lamriben, Xiaobin Song, Yu Luo, Lei Le, Hong-Ye Zhao, Hong-Jiang Wei, Michele Youd, Mailin Li, Yangbin Gao, Qi Zhang, Hongwei Dou, Dharmendra Goswami, Haydy George, Meng Yang, Yanan Yue, Yixuan Zhou, Zhuo Li, Shi Yun Wang, Lingling Song, James F. Markmann, Yuan Ding, Wenning Qin, Xueqiong Wang, Jiajia Wu, Tien Dat Nguyen, Xin Fang, Jianxiong Guo, Weihong Xu

Publikováno v: Nature Biomedical Engineering. 5:134-143

The clinical applicability of porcine xenotransplantation-a long-investigated alternative to the scarce availability of human organs for patients with organ failure-is limited by molecular incompatibilities between the immune systems of pigs and huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4620e6209389e804949c3e722376a6
https://doi.org/10.1038/s41551-020-00613-9

Extensive Mammalian Germline Genome Engineering

Autor: Ranjith P. Anand, Yu Luo, Shi Yun Wang, Hong-Jiang Wei, Juan Xiong, Deling Jiao, Violette Paragas, Yinan Kan, Yangbin Gao, Wenning Qin, Tien Dat Nguyen, George M. Church, Hongwei Dou, Jianxiong Guo, Yixuan Zhou, Shengyi Mao, Weihong Xu, Marc Güell, Jacob V. Layer, Hong-Ye Zhao, Mailin Li, Xin Fang, Xiaobin Song, Qi Zhang, Lei Le, William F. Westlin, Luhan Yang, Zhuo Li, Lingling Song, Xueqiong Wang, Jiajia Wu, Yuan Ding, James F. Markmann, Lydia Lamriben, Michele Youd, Weilin Wang, Zhongquan Sun, Mengyuan Xu, Meng Yang, Dharmendra Goswami, Yanan Yue, Haydy George

Xenotransplantation, specifically the use of porcine organs for human transplantation, has long been sought after as an alternative for patients suffering from organ failure. However, clinical application of this approach has been impeded by two main

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a3dbf2be5e71b1ce5cbdd292ed0d75
https://doi.org/10.1101/2019.12.17.876862

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

Autor: Heng Zhao, Gang Wang, Yonglun Luo, Emal Lesha, Deling Jiao, Yinan Kan, Ellen Shrock, George M. Church, Hong-Jiang Wei, Yong Wang, Hong Wei, I-Hsiu Lee, Marc Güell, Dong Niu, Shouqi Wang, Xiaoyang Zhou, Haydy George, Tao Wang, Lin Lin, Yubo Qing, Hong-Ye Zhao, Luhan Yang

Publikováno v: Niu, D, Wei, H-J, Lin, L, George, H, Wang, T, Lee, I-H, Zhao, H-Y, Kan, Y, Shrock, E, Lesha, E, Wang, G, Luo, Y, Qing, Y, Jiao, D, Zhao, H, Zhou, X, Wang, S, Wei, H, Güell, M, Church, G M & Yang, L 2017, ' Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 ', Science, vol. 357, no. 6357, pp. 1303-1307 . https://doi.org/10.1126/science.aan4187
Recercat. Dipósit de la Recerca de Catalunya
instname

Xenotransplantation is a promising strategy to alleviate the shortage of organs for human transplantation. In addition to the concerns about pig-to-human immunological compatibility, the risk of cross-species transmission of porcine endogenous retrov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3112b4627b35d171a172f23b1e294ed
http://hdl.handle.net/10230/35752