CD28-CD57+ T cells from head and neck cancer patients produce high levels of cytotoxic granules and type II interferon but are not senescent

Autor: Brendan L.C. Kinney, Brianna Brammer, Vikash Kansal, Connor J. Parrish, Haydn T. Kissick, Yuan Liu, Nabil F. Saba, Zachary S. Buchwald, Mark W. El-Deiry, Mihir R. Patel, Brian J. Boyce, Azeem S. Kaka, Jennifer H. Gross, H. Michael Baddour, Amy Y. Chen, Nicole C. Schmitt

Publikováno v: OncoImmunology, Vol 13, Iss 1 (2024)

T lymphocytes expressing CD57 and lacking costimulatory receptors CD27/CD28 have been reported to accumulate with aging, chronic infection, and cancer. These cells are described as senescent, with inability to proliferate but enhanced cytolytic and c

Externí odkaz: https://doaj.org/article/3967eb4b36174a4b8c3720cf04420d75

The scavenger receptor MARCO modulates TLR-induced responses in dendritic cells.

Autor: Haydn T Kissick, Laura K Dunn, Sanjukta Ghosh, Morris Nechama, Lester Kobzik, Mohamed S Arredouani

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104148 (2014)

The scavenger receptor MARCO mediates macrophage recognition and clearance of pathogens and their polyanionic ligands. However, recent studies demonstrate MARCO expression and function in dendritic cells, suggesting MARCO might serve to bridge innate

Externí odkaz: https://doaj.org/article/8d0e54cf482d4eca9c7a2c922af030dc

Body Composition Variables as Radiographic Biomarkers of Clinical Outcomes in Metastatic Renal Cell Carcinoma Patients Receiving Immune Checkpoint Inhibitors

Autor: Dylan J. Martini, T. Anders Olsen, Subir Goyal, Yuan Liu, Sean T. Evans, Benjamin Magod, Jacqueline T. Brown, Lauren Yantorni, Greta Anne Russler, Sarah Caulfield, Jamie M. Goldman, Bassel Nazha, Haydn T. Kissick, Wayne B. Harris, Omer Kucuk, Bradley C. Carthon, Viraj A. Master, Mehmet Asim Bilen

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

BackgroundImmune checkpoint inhibitors (ICI) have revolutionized the treatment of metastatic renal cell carcinoma (mRCC). Biomarkers for mRCC patients treated with ICI are limited, and body composition is underutilized in mRCC. We investigated the as

Externí odkaz: https://doaj.org/article/9162907753ca46b98f276622972a2ce3

Expression of novel long noncoding RNAs defines virus-specific effector and memory CD8+ T cells

Autor: William H. Hudson, Nataliya Prokhnevska, Julia Gensheimer, Rama Akondy, Donald J. McGuire, Rafi Ahmed, Haydn T. Kissick

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Long noncoding RNA (lncRNA) genes do not encode protein products yet are emerging as key regulators of cellular processes such as transcription and translation. Here, by examining lncRNA profiles from human and mouse CD8 T cells, the authors show tha

Externí odkaz: https://doaj.org/article/3fba6bfb088047b99a9728dd3fed18bd

Invariant NKT cell-augmented GM-CSF-secreting tumor vaccine is effective in advanced prostate cancer model

Autor: Bindu Varghese, Lydia Lynch, Lianne E. Vriend, Dobrin Draganov, Justice M. Clark, Haydn T. Kissick, Sharlin Varghese, Martin G. Sanda, Glenn Dranoff, M. Simo Arredouani, Steven P. Balk, Mark A. Exley

Publikováno v: Varghese, B, Lynch, L, Vriend, L E, Draganov, D, Clark, J M, Kissick, H T, Varghese, S, Sanda, M G, Dranoff, G, Arredouani, M S, Balk, S P & Exley, M A 2022, ' Invariant NKT cell-augmented GM-CSF-secreting tumor vaccine is effective in advanced prostate cancer model ', Cancer Immunology, Immunotherapy, vol. 71, no. 12, pp. 2943-2955 . https://doi.org/10.1007/s00262-022-03210-8
Cancer Immunology, Immunotherapy, 71(12), 2943-2955. Springer Science and Business Media Deutschland GmbH

Invariant natural killer T cells (iNKT cells) express a semi-invariant T cell receptor that recognizes certain glycolipids (including α-galactosylceramide, αGC) bound to CD1d, and can induce potent antitumor responses. Here, we assessed whether αG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a096f8da2884cfb2bc0afcb284506317
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