Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Haydn M, Prosser"'
Autor:
Ionel Sandovici, Denise S. Fernandez-Twinn, Niamh Campbell, Wendy N. Cooper, Yoichi Sekita, Ilona Zvetkova, David Ferland-McCollough, Haydn M. Prosser, Lila M. Oyama, Lucas C. Pantaleão, Danilo Cimadomo, Karina Barbosa de Queiroz, Cecilia S.K. Cheuk, Nicola M. Smith, Richard G. Kay, Robin Antrobus, Katharina Hoelle, Marcella K.L. Ma, Noel H. Smith, Stefan H. Geyer, Lukas F. Reissig, Wolfgang J. Weninger, Kenneth Siddle, Anne E. Willis, Brian Y.H. Lam, Martin Bushell, Susan E. Ozanne, Miguel Constância
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114750- (2024)
Summary: Mir483 is a conserved and highly expressed microRNA in placental mammals, embedded within the Igf2 gene. Its expression is dysregulated in a number of human diseases, including metabolic disorders and certain cancers. Here, we investigate th
Externí odkaz:
https://doaj.org/article/abbc32c9c19d41bf953422abe96dc435
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
The microRNA miR-96 is important for hearing, as point mutations in humans and mice result in dominant progressive hearing loss. Mir96 is expressed in sensory cells along with Mir182 and Mir183, but the roles of these closely-linked microRNAs are as
Externí odkaz:
https://doaj.org/article/1f431935b8b34900a4667b980d91afe7
Autor:
Constanze M Hammerle, Ionel Sandovici, Gemma V Brierley, Nicola M Smith, Warren E Zimmer, Ilona Zvetkova, Haydn M Prosser, Yoichi Sekita, Brian Y H Lam, Marcella Ma, Wendy N Cooper, Antonio Vidal-Puig, Susan E Ozanne, Gema Medina-Gómez, Miguel Constância
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009069 (2020)
The genetic mechanisms that determine the size of the adult pancreas are poorly understood. Imprinted genes, which are expressed in a parent-of-origin-specific manner, are known to have important roles in development, growth and metabolism. However,
Externí odkaz:
https://doaj.org/article/dd9ff8b3a079402997344c273ba5478c
Autor:
Kevin White, Yu Lu, Sofia Annis, Andrew E Hale, B Nelson Chau, James E Dahlman, Craig Hemann, Alexander R Opotowsky, Sara O Vargas, Ivan Rosas, Mark A Perrella, Juan C Osorio, Kathleen J Haley, Brian B Graham, Rahul Kumar, Rajan Saggar, Rajeev Saggar, W Dean Wallace, David J Ross, Omar F Khan, Andrew Bader, Bernadette R Gochuico, Majed Matar, Kevin Polach, Nicolai M Johannessen, Haydn M Prosser, Daniel G Anderson, Robert Langer, Jay L Zweier, Laurence A Bindoff, David Systrom, Aaron B Waxman, Richard C Jin, Stephen Y Chan
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 6, Pp 695-713 (2015)
Abstract Iron–sulfur (Fe‐S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR‐210‐ISCU1/2 axis cause Fe‐S deficiencies in v
Externí odkaz:
https://doaj.org/article/2ba2fa97eac5474ab7e2db24f409a724
Autor:
Haydn M. Prosser, Caifu Chen, Michael T. McManus, Bin Xue, Allan Bradley, Maximilian Kühn, Jingqi Chen, Yalei Wu, Bo Su, Neil Sahasrabudhe, Cesar Seigi Fuziwara, Anne Biton, John E. Wilkinson, Monte M. Winslow, Chen-Hua Chuang, Claudia Chan, Lin He
Publikováno v:
Genes Dev
Lung adenocarcinoma, the most prevalent lung cancer subtype, is characterized by its high propensity to metastasize. Despite the importance of metastasis in lung cancer mortality, its underlying cellular and molecular mechanisms remain largely elusiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c32b0a56c3f7d2876788f0bd6b7612
https://doi.org/10.1101/gad.347344.120
https://doi.org/10.1101/gad.347344.120
Autor:
James Dooley, Vasiliki Lagou, Emanuela Pasciuto, Michelle A. Linterman, Haydn M. Prosser, Uwe Himmelreich, Adrian Liston
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
The intronic microRNA (miR)-342 has been proposed as a potent tumor-suppressor gene. miR-342 is found to be downregulated or epigenetically silenced in multiple different tumor sites, and this loss of expression permits the upregulation of several ke
Externí odkaz:
https://doaj.org/article/985a8ca8399544a1a151131e281c7f01
Autor:
Ionel Sandovici, Denise S. Fernandez-Twinn, Niamh Campbell, Wendy N. Cooper, Yoichi Sekita, Ilona Zvetkova, David Ferland-McCollough, Haydn M. Prosser, Lila M. Oyama, Danilo Cimadomo, Karina Barbosa de Queiroz, Cecilia S.K. Cheuk, Nicola M. Smith, Richard G. Kay, Katharina Hoelle, Noel H. Smith, Stefan H. Geyer, Lukas F. Reissig, Wolfgang J. Weninger, Kenneth Siddle, Anne E. Willis, Martin Bushell, Susan E. Ozanne, Miguel Constância
Mir483 is a conserved and highly expressed microRNA in placental mammals, embedded within the Igf2 gene. Here, we uncover the control mechanisms and physiological functions of Mir483 in vivo, by generating constitutive loss-of-function and over-expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a46e279bb69b26d85a948cbb47f5772a
https://doi.org/10.1101/2022.09.09.507324
https://doi.org/10.1101/2022.09.09.507324
Autor:
Haydn M. Prosser, Yvette Dörflinger, Lena Ebbers, Simone Hoppe, Constanze Krohs, Faiza Altaf, Christoph Körber, Hans Gerd Nothwang, Giulia Hollje
Publikováno v:
J Neurosci
A point mutation in miR-96 causes non-syndromic progressive peripheral hearing loss and alters structure and physiology of the central auditory system. To gain further insight into the functions of microRNAs (miRNAs) within the central auditory syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e985e71fe33aaa770df7590e9fb572c1
https://doi.org/10.1523/jneurosci.0139-20.2021
https://doi.org/10.1523/jneurosci.0139-20.2021
Autor:
Warren E. Zimmer, Miguel Constância, Nicola M. Smith, Wendy N. Cooper, Haydn M. Prosser, Ionel Sandovici, Gema Medina-Gómez, Yoichi Sekita, Constanze M. Hammerle, Susan E. Ozanne, Antonio Vidal-Puig, Ilona Zvetkova, Brian Y.H. Lam, Gemma V. Brierley, Marcella Ma
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009069 (2020)
PLoS Genetics
PLoS Genetics
The genetic mechanisms that determine the size of the adult pancreas are poorly understood. Imprinted genes, which are expressed in a parent-of-origin-specific manner, are known to have important roles in development, growth and metabolism. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babe513f340184b0d087d55fc9232f5a
https://www.repository.cam.ac.uk/handle/1810/313200
https://www.repository.cam.ac.uk/handle/1810/313200
Autor:
Lin He, Bo Su, Neil Sahasrabudhe, Caifu Chen, Michael T. McManus, Yalei Wu, Jingqi Chen, Claudia Chan, Chen-Hua Chuang, Bin Xue, Maximilian Kühn, Monte M. Winslow, Allan Bradley, Cesar Seigi Fuziwara, John E. Wilkinson, Haydn M. Prosser, Anne Biton
Lung adenocarcinoma, the most prevalent lung cancer subtype, is characterized by its high propensity to metastasize. Despite the importance of metastasis in lung cancer mortality, its underlying cellular and molecular mechanisms remain largely elusiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fb1e6474be0d6a83407c13dd40d1cad
https://doi.org/10.1101/2020.09.02.276550
https://doi.org/10.1101/2020.09.02.276550